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    DRUG CLASS:

    VEGF-B inhibitor

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    Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer (NCT02298959)
    Phase 1
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    06/05/2024
    Initiation :
    04/08/2015
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    CD8 • HGF • CTAG1B • CD4 • FGF • MLANA
    |
    Keytruda (pembrolizumab) • Zaltrap (ziv-aflibercept IV)
    VEGF Trap in Treating Patients With Previously Treated Metastatic Colorectal Cancer (NCT00407654)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    03/04/2024
    Initiation :
    10/01/2006
    Primary completion :
    09/01/2012
    Completion :
    09/01/2012
    EGFR
    |
    Zaltrap (ziv-aflibercept IV)
    Phase I Study to Evaluate Safety and Anti-tumor Activity of PB101, an Anti-angiogenic Immunomodulating Agent (NCT06075849)
    Phase 1
    Panolos Bioscience
    Recruiting
    Last update posted :
    02/23/2024
    Initiation :
    10/25/2023
    Primary completion :
    10/01/2024
    Completion :
    01/01/2025
    FLT1
    |
    PB101
    TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study. (NCT04392479)
    Phase 3
    GCS IHFB Cognacq-Jay
    Active, not recruiting
    Last update posted :
    10/23/2023
    Initiation :
    09/02/2020
    Primary completion :
    06/15/2023
    Completion :
    06/01/2024
    KDR • FLT4 • VEGFC
    |
    5-fluorouracil • irinotecan • leucovorin calcium • Zaltrap (ziv-aflibercept IV)
    Ziv-Aflibercept for Advanced Progressive Carcinoid Tumors (NCT01782443)
    Phase 2
    Dana-Farber Cancer Institute
    Completed
    Last update posted :
    08/14/2023
    Initiation :
    02/13/2013
    Primary completion :
    03/01/2021
    Completion :
    12/26/2021
    CHGA
    |
    Zaltrap (ziv-aflibercept IV)
    Aflibercept +/- LV5FU2 in First Line of Non-resectalbe Metastatic Colorectal Cancers (FOLFA) (NCT02384759)
    Phase 2
    Federation Francophone de Cancerologie Digestive
    Completed
    Last update posted :
    04/04/2022
    Initiation :
    05/01/2015
    Primary completion :
    06/01/2021
    Completion :
    06/01/2021
    TYMS
    |
    Zaltrap (ziv-aflibercept IV)
    Clinical Trial of Combination Chemotherapy With Aflibercept in Patients With Advanced Colorectal Cancer (AMALTHEA) (NCT02129257)
    Phase 2
    Hellenic Cooperative Oncology Group
    Completed
    Last update posted :
    10/24/2017
    Initiation :
    05/26/2014
    Primary completion :
    01/01/2017
    Completion :
    09/25/2017
    KDR • HGF • HIF1A • FLT1 • VEGFB • VEGFC • FGF • NRP1
    |
    5-fluorouracil • irinotecan • leucovorin calcium • Zaltrap (ziv-aflibercept IV)
    Ziv-Aflibercept in Treating Patients With Metastatic or Unresectable Kidney Cancer (NCT00357760)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    06/23/2017
    Initiation :
    12/01/2007
    Primary completion :
    10/01/2015
    Completion :
    10/01/2015
    VEGFA • IL2
    |
    Zaltrap (ziv-aflibercept IV)
    Aflibercept in Treating Patients With Recurrent and/or Metastatic Thyroid Cancer That Did Not Respond to Radioactive Iodine Therapy (NCT00729157)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    03/15/2017
    Initiation :
    08/01/2008
    Primary completion :
    10/01/2012
    Completion :
    11/01/2012
    TG
    |
    Zaltrap (ziv-aflibercept IV)
    Study of AVE0005 (VEGF Trap) in Patients With Chemoresistant Advanced Ovarian Cancer (NCT00327171)
    Phase 2
    Sanofi
    Completed
    Last update posted :
    06/07/2016
    Initiation :
    05/01/2006
    Primary completion :
    04/01/2008
    Completion :
    03/01/2010
    MUC16
    |
    topotecan • Zaltrap (ziv-aflibercept IV)