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    Tubulin inhibitor

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    Nab-Paclitaxel in Treating Older Patients With Locally Advanced or Metastatic Breast Cancer (NCT01463072)
    Phase 2
    City of Hope Medical Center
    Active, not recruiting
    Last update posted :
    02/19/2025
    Initiation :
    06/19/2012
    Primary completion :
    05/17/2017
    Completion :
    06/17/2025
    HER-2 • ER
    |
    albumin-bound paclitaxel
    Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients of Different Ages With Metastatic Breast Cancer (NCT00609791)
    Phase 2
    City of Hope Medical Center
    Active, not recruiting
    Last update posted :
    02/19/2025
    Initiation :
    02/11/2008
    Primary completion :
    10/25/2011
    Completion :
    05/15/2025
    HER-2 • ER
    |
    albumin-bound paclitaxel
    Adjuvant Dynamic Marker-Adjusted Personalized Therapy Trial Optimizing Risk Assessment and Therapy Response Prediction in Early Breast Cancer - Triple Negative Breast Cancer (WSG-ADAPT-TN) (NCT01815242)
    Phase 2
    West German Study Group
    Active, not recruiting
    Last update posted :
    11/20/2024
    Initiation :
    06/01/2013
    Primary completion :
    03/01/2015
    Completion :
    12/01/2024
    HER-2
    |
    carboplatin • gemcitabine • albumin-bound paclitaxel
    A Study of CBP-1018 in Patients With Advanced Solid Tumors (NCT04928612)
    Phase 1
    Coherent Biopharma (Suzhou) Co., Ltd.
    Recruiting
    Last update posted :
    08/28/2024
    Initiation :
    11/04/2021
    Primary completion :
    10/01/2024
    Completion :
    12/01/2024
    FOLR1
    |
    CBP-1018
    The PLATINUM Trial: Optimizing Chemotherapy for the Second-Line Treatment of Metastatic BRCA1/2 or PALB2-Associated Metastatic Pancreatic Cancer (NCT06115499)
    Phase 2/3
    Alliance for Clinical Trials in Oncology
    Recruiting
    Last update posted :
    05/23/2024
    Initiation :
    12/06/2023
    Primary completion :
    01/15/2029
    Completion :
    12/09/2029
    BRCA1 • BRCA2
    |
    PALB2 mutation
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel
    FID-007 Followed by Standard of Care Surgery in Head and Neck Cancer (NCT06338657)
    Phase 1
    University of Southern California
    Recruiting
    Last update posted :
    05/17/2024
    Initiation :
    04/01/2024
    Primary completion :
    04/01/2026
    Completion :
    04/01/2027
    PD-1 • BCL6 • LAG3 • CD38 • TIGIT • CCR7 • GZMB • BTLA • PRDM1 • CXCR3 • SIGLEC15
    |
    paclitaxel • nanoencapsulated paclitaxel (FID-007)
    Pan-T Booster Co-expressing MSLN CAR T Cell Therapy in Advanced/Metastatic Solid Tumors (NCT05693844)
    Phase 1/2
    Chinese PLA General Hospital
    Recruiting
    Last update posted :
    05/10/2024
    Initiation :
    01/20/2023
    Primary completion :
    12/31/2025
    Completion :
    12/31/2026
    MSLN
    |
    MSLN expression
    |
    albumin-bound paclitaxel • cyclophosphamide • fludarabine IV • CD40 ligand expressing MSLN-CAR T
    ARX517 in Subjects With Metastatic Castration-Resistant Prostate Cancer (APEX-01) (NCT04662580)
    Phase 1
    Ambrx, Inc.
    Recruiting
    Last update posted :
    05/10/2024
    Initiation :
    07/27/2021
    Primary completion :
    12/01/2025
    Completion :
    03/01/2027
    FOLH1
    |
    FOLH1 expression
    |
    Xtandi (enzalutamide) • JNJ-95298177
    ProAgio in Pancreatic Ductal Adenocarcinoma (PDAC) (NCT06182072)
    Phase 1
    ProDa BioTech, LLC
    Recruiting
    Last update posted :
    04/25/2024
    Initiation :
    09/14/2023
    Primary completion :
    07/01/2025
    Completion :
    10/01/2025
    PKM
    |
    gemcitabine • albumin-bound paclitaxel
    Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases (NCT05285358)
    Phase 1
    City of Hope Medical Center
    Recruiting
    Last update posted :
    03/07/2024
    Initiation :
    09/19/2022
    Primary completion :
    10/11/2028
    Completion :
    10/11/2028
    CD4
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel
    Neoadjuvant Chemotherapy With Nab-paclitaxel in Women With HER2-negative High-risk Breast Cancer (ETNA) (NCT01822314)
    Phase 3
    Fondazione Michelangelo
    Completed
    Last update posted :
    03/07/2024
    Initiation :
    04/01/2013
    Primary completion :
    09/01/2016
    Completion :
    03/01/2023
    HER-2 • ER • PGR
    |
    HER-2 negative • PGR positive
    |
    doxorubicin hydrochloride • albumin-bound paclitaxel • cyclophosphamide • epirubicin
    Neoadjuvant Therapy in TRIPle Negative Breast Cancer With antiPDL1 (NeoTRIPaPDL1) (NCT02620280)
    Phase 3
    Fondazione Michelangelo
    Completed
    Last update posted :
    03/06/2024
    Initiation :
    04/01/2016
    Primary completion :
    01/01/2024
    Completion :
    01/07/2024
    HER-2 • ER • PGR
    |
    PD-L1 expression • HER-2 negative • ER negative
    |
    Tecentriq (atezolizumab) • carboplatin • doxorubicin hydrochloride • albumin-bound paclitaxel • cyclophosphamide • epirubicin
    Oral Paclitaxel Efficacy Safety and PK in Recurrent and Metastatic Breast Cancer (OPERA) (NCT03326102)
    Phase 2
    Daehwa Pharmaceutical Co., Ltd.
    Completed
    Last update posted :
    02/16/2024
    Initiation :
    07/06/2018
    Primary completion :
    12/13/2022
    Completion :
    12/13/2022
    HER-2
    |
    HER-2 negative
    |
    Liporaxel (paclitaxel oral)
    Response to Neoadjuvant Chemoimmunotherapy in Resectable Locally Advanced Oral Cancer (HNC-SYSU-005) (NCT06143761)
    Phase N/A
    Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Un...
    Completed
    Last update posted :
    11/22/2023
    Initiation :
    12/01/2020
    Primary completion :
    06/30/2022
    Completion :
    06/30/2022
    PD-L1
    |
    carboplatin • albumin-bound paclitaxel
    Study of ZV0203 in Patients With HER2-Positive Advanced Solid Tumors (ZV0203-001CN) (NCT05423977)
    Phase 1
    Hangzhou Adcoris Biopharmacy Co., Ltd
    Enrolling by invitation
    Last update posted :
    11/20/2023
    Initiation :
    12/17/2021
    Primary completion :
    05/05/2023
    Completion :
    07/07/2024
    HER-2
    |
    HER-2 positive
    |
    ADC2122
    Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma (SC9/ABX) (NCT04528680)
    Phase 1/2
    Northwestern University
    Recruiting
    Last update posted :
    11/15/2023
    Initiation :
    10/29/2020
    Primary completion :
    09/10/2024
    Completion :
    09/01/2025
    IDH1 • SSR3
    |
    IDH wild-type • IDH1 R132
    |
    carboplatin • albumin-bound paclitaxel
    Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma (ProglumidePanc) (NCT06017323)
    Phase 1
    Georgetown University
    Withdrawn
    Last update posted :
    10/25/2023
    Initiation :
    10/01/2023
    Primary completion :
    07/01/2026
    Completion :
    07/01/2026
    CA 19-9
    |
    gemcitabine • albumin-bound paclitaxel
    Gemcitabine With Abraxane and Other Investigational Therapies in Neoadjuvant Treatment of Pancreatic Adenocarcinoma (GAIN-1) (NCT01470417)
    Phase 2
    University of Florida
    Completed
    Last update posted :
    08/22/2023
    Initiation :
    10/01/2011
    Primary completion :
    01/01/2014
    Completion :
    10/01/2019
    CA 19-9
    |
    gemcitabine • albumin-bound paclitaxel
    Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene (NCT03602079)
    Phase 1/2
    Klus Pharma Inc.
    Completed
    Last update posted :
    08/03/2023
    Initiation :
    07/16/2018
    Primary completion :
    01/12/2022
    Completion :
    01/12/2022
    HER-2
    |
    HER-2 positive • HER-2 expression
    |
    trastuzumab botidotin (A166)
    Nab-paclitaxel/Rituximab-coated Nanoparticle AR160 in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma, LS1681 Trial (NCT03003546)
    Phase 1
    Mayo Clinic
    Completed
    Last update posted :
    06/15/2023
    Initiation :
    04/25/2019
    Primary completion :
    05/16/2023
    Completion :
    05/16/2023
    CD20
    |
    Rituxan (rituximab) • albumin-bound paclitaxel • nab-paclitaxel/rituximab nanoparticle (AR160)
    Schedules of Nab-Paclitaxel in Metastatic Breast Cancer (SNAP) (NCT01746225)
    Phase 2
    ETOP IBCSG Partners Foundation
    Completed
    Last update posted :
    06/01/2023
    Initiation :
    04/01/2013
    Primary completion :
    05/01/2016
    Completion :
    03/16/2023
    HER-2 • ER
    |
    ER positive • HER-2 negative • ER negative
    |
    albumin-bound paclitaxel
    Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors (NCT00499291)
    Phase N/A
    Eastern Cooperative Oncology Group
    Withdrawn
    Last update posted :
    05/25/2023
    Initiation :
    09/01/2006
    CYP2C8
    |
    albumin-bound paclitaxel
    Safety and Tolerance of Epigenetic and Immunomodulating Drugs Combined With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer (SEPION) (NCT04257448)
    Phase 1/2
    GWT-TUD GmbH
    Active, not recruiting
    Last update posted :
    05/01/2023
    Initiation :
    05/25/2020
    Primary completion :
    03/01/2024
    Completion :
    03/01/2024
    CA 19-9
    |
    Imfinzi (durvalumab) • gemcitabine • lenalidomide • azacitidine • albumin-bound paclitaxel • Istodax (romidepsin)
    A Trial Evaluating the Efficacy and Safety of EndoTAG®-1 in Combination With Paclitaxel and Gemcitabine Compared With Paclitaxel and Gemcitabine as First-line Therapy in Patients With Visceral Metastatic Triple-negative Breast Cancer (NCT03002103)
    Phase 3
    SynCore Biotechnology Co., Ltd.
    Suspended
    Last update posted :
    04/26/2023
    Initiation :
    11/23/2016
    Primary completion :
    03/01/2025
    Completion :
    06/01/2027
    HER-2
    |
    gemcitabine • EndoTAG-1 (paclitaxel liposomal)
    Abraxane With Bevacizumab Biosimilar in Patients With Recurrent, Platinum-resistant Epithelial Ovarian Cancer (NCT04670978)
    Phase 2
    Shandong University
    Recruiting
    Last update posted :
    04/25/2023
    Initiation :
    03/31/2021
    Primary completion :
    12/31/2023
    Completion :
    12/31/2024
    MUC16
    |
    albumin-bound paclitaxel
    ANG1005 in Leptomeningeal Disease From Breast Cancer (ANGLeD) (NCT03613181)
    Phase 3
    Angiochem Inc
    Not yet recruiting
    Last update posted :
    04/24/2023
    Initiation :
    12/01/2023
    Primary completion :
    12/01/2024
    Completion :
    12/01/2024
    HER-2
    |
    HER-2 negative
    |
    capecitabine • Halaven (eribulin mesylate) • methotrexate IV • paclitaxel trevatide (ANG1005)
    Nab-Paclitaxel + Cisplatin + Gemcitabine in Untreated Metastatic Pancreatic Adenocarcinoma (NCT03915444)
    Phase 2
    HonorHealth Research Institute
    Active, not recruiting
    Last update posted :
    04/17/2023
    Initiation :
    07/15/2019
    Primary completion :
    05/13/2022
    Completion :
    07/31/2023
    MUC16
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel
    Neoadjuvant Treatment With Nab-paclitaxel for Patients With Stage II and III Luminal Breast Cancer (NCT01565499)
    Phase 2
    Spanish Breast Cancer Research Group
    Completed
    Last update posted :
    03/30/2023
    Initiation :
    04/17/2012
    Primary completion :
    06/01/2014
    Completion :
    05/27/2018
    HER-2 • ER • PGR • CAV1
    |
    ER positive • HER-2 negative
    |
    albumin-bound paclitaxel
    TCR-T Cells for the Treatment NY-ESO-1-positive Advanced Solid Tumors (NCT05648994)
    Phase 1
    Fujian Cancer Hospital
    Not yet recruiting
    Last update posted :
    12/13/2022
    Initiation :
    12/01/2022
    Primary completion :
    02/01/2024
    Completion :
    03/01/2026
    CTAG1B
    |
    albumin-bound paclitaxel • cyclophosphamide • fludarabine IV
    Neoadjuvant Nab-paclitaxel in Triple-negative or HER2-positive Breast Cancer (NeoPATH) (NCT03907800)
    Phase 2
    Ruijin Hospital
    Recruiting
    Last update posted :
    10/27/2022
    Initiation :
    04/01/2019
    Primary completion :
    10/01/2022
    Completion :
    10/01/2022
    HER-2 • PGR
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • carboplatin • albumin-bound paclitaxel
    Nab-paclitaxel Dose Schedual for HER-2 Negative Advanced Breast Cancer (NCT04192331)
    Phase 2
    Peking University Cancer Hospital & Institute
    Active, not recruiting
    Last update posted :
    10/13/2022
    Initiation :
    02/21/2019
    Primary completion :
    01/26/2023
    Completion :
    01/26/2023
    HER-2
    |
    HER-2 negative
    |
    albumin-bound paclitaxel
    Efficacy and Safety of HGXJT in Bone Metastatic NSCLC Patients (NCT05378334)
    Phase N/A
    Guangzhou University of Traditional Chinese Med...
    Recruiting
    Last update posted :
    08/15/2022
    Initiation :
    06/15/2022
    Primary completion :
    03/01/2024
    Completion :
    03/01/2025
    EGFR • ALK
    |
    carboplatin • albumin-bound paclitaxel
    Neoadjuvant Inituomab, Pyrrolidone and Nab-paclitaxel for HER2+Breast Cancer (NCT05444998)
    Phase 2
    Xijing Hospital
    Not yet recruiting
    Last update posted :
    07/06/2022
    Initiation :
    11/01/2022
    Primary completion :
    08/31/2023
    Completion :
    12/31/2023
    HER-2
    |
    HER-2 positive • HER-2 amplification
    |
    albumin-bound paclitaxel • cyclophosphamide • epirubicin • nintedanib
    A Study for the Neoadjuvant Treatment of Breast Cancer (NCT05420454)
    Phase 4
    Second Affiliated Hospital, School of Medicine,...
    Recruiting
    Last update posted :
    07/01/2022
    Initiation :
    07/10/2022
    Primary completion :
    06/10/2027
    Completion :
    12/20/2027
    HER-2 • ER • PGR
    |
    HER-2 positive • HER-2 negative • HER-2 expression • ER negative • PGR positive
    |
    Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab) • albumin-bound paclitaxel • cyclophosphamide • epirubicin
    A Study for the Adjuvant Treatment of Breast Cancer (NCT05420467)
    Phase 4
    Second Affiliated Hospital, School of Medicine,...
    Recruiting
    Last update posted :
    07/01/2022
    Initiation :
    07/10/2022
    Primary completion :
    07/10/2027
    Completion :
    12/20/2027
    HER-2 • ER • PGR
    |
    HER-2 positive • HER-2 negative • HER-2 expression • ER negative • PGR positive
    |
    Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab) • albumin-bound paclitaxel • cyclophosphamide • epirubicin
    Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy (NCT05341141)
    Phase N/A
    Peking University
    Recruiting
    Last update posted :
    06/13/2022
    Initiation :
    06/10/2022
    Primary completion :
    08/01/2026
    Completion :
    11/01/2026
    HER-2
    |
    HER-2 negative
    |
    albumin-bound paclitaxel • cyclophosphamide • epirubicin
    Trial of Nab-paclitaxel in Patients With Desmoid Tumors and Multiply Relapsed/Refractory Desmoplastic Small Round Cell Tumors and Ewing Sarcoma (ABRADES) (NCT03275818)
    Phase 2
    Grupo Espanol de Investigacion en Sarcomas
    Completed
    Last update posted :
    06/07/2022
    Initiation :
    05/09/2017
    Primary completion :
    09/30/2021
    Completion :
    09/30/2021
    CTNNB1 • SPARC
    |
    CTNNB1 mutation
    |
    albumin-bound paclitaxel
    PLD-cyclophosphamide-Nab-P Continuously Combined With Dual HER2 Blockage for HER2-positive Breast Cancer (Brecan) (NCT05346107)
    Phase 2
    Xijing Hospital
    Recruiting
    Last update posted :
    04/26/2022
    Initiation :
    01/01/2020
    Primary completion :
    12/31/2022
    Completion :
    12/31/2023
    HER-2
    |
    HER-2 positive
    |
    Perjeta (pertuzumab) • albumin-bound paclitaxel • cyclophosphamide • pegylated liposomal doxorubicin
    A Study of A166 in Patients With Advanced Solid Malignant Tumors (NCT05311397)
    Phase 1
    Sichuan Kelun Pharmaceutical Research Institute...
    Recruiting
    Last update posted :
    04/14/2022
    Initiation :
    08/09/2018
    Primary completion :
    06/30/2023
    Completion :
    12/31/2023
    HER-2
    |
    HER-2 positive • HER-2 expression
    |
    trastuzumab botidotin (A166)
    Adjuvant Albumin-bound Paclitaxel Versus Taxanes in Breast Cancer: a Real-world Study (NCT05287308)
    Phase N/A
    Chinese Academy of Medical Sciences
    Not yet recruiting
    Last update posted :
    03/31/2022
    Initiation :
    03/01/2022
    Primary completion :
    09/01/2027
    Completion :
    09/01/2027
    HER-2
    |
    HR positive • HER-2 negative
    |
    docetaxel • doxorubicin hydrochloride • albumin-bound paclitaxel • cyclophosphamide • epirubicin • Pinorubin (pirarubicin)