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DRUG:
topotecan
i
Other names:
NK 211, NK-211, NK211, NSC 609699, SKF 104864
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Associations
(16)
News
Trials
Company:
Generic mfg.
Drug class:
Topoisomerase I inhibitor
Related drugs:
‹
fam-trastuzumab deruxtecan-nxki (90)
irinotecan (48)
U3-1402 (28)
sacituzumab govitecan-hziy (17)
SHR-A1811 (15)
datopotamab deruxtecan (11)
DM001 (6)
DS-7300 (5)
AZD8205 (5)
AMB302 (4)
DB-1310 (4)
DM002 (4)
BNT323 (4)
BL-M07D1 (3)
DS-6157 (3)
HRA00129-C004 (3)
sacituzumab tirumotecan (3)
nanoliposomal irinotecan (3)
PLX038 (3)
ABBV-400 (3)
CUSP06 (2)
DAN-222 (2)
DM005 (2)
PRO1102 (2)
SSH20 (2)
IMMU-130 (2)
AZD9592 (2)
AMT-562 (1)
AZD5335 (1)
BAT8008 (1)
BL-M02D1 (1)
BNT324 (1)
camptothecin nanosomal (1)
DAN-311 (1)
ELU001 (1)
HMBD-501 (1)
IBI-343 (1)
IMMU-140 (1)
IT-141 (1)
OBI-992 (1)
OQY-3258 (1)
PF-08046044 (1)
rinatabart sesutecan (1)
SGN-CD30C (1)
SHR-A2102 (1)
STRO-003 (1)
ZW191 (1)
ZW220 (1)
ZW251 (1)
BL-B01D1 (1)
ABBV-706 (0)
ARC-401 (0)
BAT8007 (0)
BAT8010 (0)
BL-M11D1 (0)
BNT326 (0)
CEB-01 (0)
belotecan (0)
DS-3939 (0)
FZ-AD004 (0)
GEN1160 (0)
GSK5733584 (0)
GSK5764227 (0)
HA-irinotecan (0)
HLX43 (0)
IBI-354 (0)
ICAM‑1 ADC (0)
JSKN003 (0)
LMP744 (0)
LY4170156 (0)
lentinan (0)
TLC388 (0)
MHB036C (0)
MHB088C (0)
NK012 (0)
etirinotecan pegol (0)
SHR-A1904 (0)
SHR-A1912 (0)
SHR-A2009 (0)
SKB315 (0)
TQB2102 (0)
TQB2103 (0)
VIP236 (0)
YL201 (0)
CBX-12 (0)
EP0057 (0)
LMP400 (0)
HR070803 (0)
irinotecan liposomal (0)
LY01616 (0)
FF-10850 (0)
PEN-866 (0)
SSS22 (0)
M9140 (0)
DS-6000 (0)
simmitecan (0)
SHR-A1921 (0)
topotecan episcleral (0)
fam-trastuzumab deruxtecan-nxki (90)
irinotecan (48)
U3-1402 (28)
sacituzumab govitecan-hziy (17)
SHR-A1811 (15)
datopotamab deruxtecan (11)
DM001 (6)
DS-7300 (5)
AZD8205 (5)
AMB302 (4)
DB-1310 (4)
DM002 (4)
BNT323 (4)
BL-M07D1 (3)
DS-6157 (3)
HRA00129-C004 (3)
sacituzumab tirumotecan (3)
nanoliposomal irinotecan (3)
PLX038 (3)
ABBV-400 (3)
CUSP06 (2)
DAN-222 (2)
DM005 (2)
PRO1102 (2)
SSH20 (2)
IMMU-130 (2)
AZD9592 (2)
AMT-562 (1)
AZD5335 (1)
BAT8008 (1)
BL-M02D1 (1)
BNT324 (1)
camptothecin nanosomal (1)
DAN-311 (1)
ELU001 (1)
HMBD-501 (1)
IBI-343 (1)
IMMU-140 (1)
IT-141 (1)
OBI-992 (1)
OQY-3258 (1)
PF-08046044 (1)
rinatabart sesutecan (1)
SGN-CD30C (1)
SHR-A2102 (1)
STRO-003 (1)
ZW191 (1)
ZW220 (1)
ZW251 (1)
BL-B01D1 (1)
ABBV-706 (0)
ARC-401 (0)
BAT8007 (0)
BAT8010 (0)
BL-M11D1 (0)
BNT326 (0)
CEB-01 (0)
belotecan (0)
DS-3939 (0)
FZ-AD004 (0)
GEN1160 (0)
GSK5733584 (0)
GSK5764227 (0)
HA-irinotecan (0)
HLX43 (0)
IBI-354 (0)
ICAM‑1 ADC (0)
JSKN003 (0)
LMP744 (0)
LY4170156 (0)
lentinan (0)
TLC388 (0)
MHB036C (0)
MHB088C (0)
NK012 (0)
etirinotecan pegol (0)
SHR-A1904 (0)
SHR-A1912 (0)
SHR-A2009 (0)
SKB315 (0)
TQB2102 (0)
TQB2103 (0)
VIP236 (0)
YL201 (0)
CBX-12 (0)
EP0057 (0)
LMP400 (0)
HR070803 (0)
irinotecan liposomal (0)
LY01616 (0)
FF-10850 (0)
PEN-866 (0)
SSS22 (0)
M9140 (0)
DS-6000 (0)
simmitecan (0)
SHR-A1921 (0)
topotecan episcleral (0)
›
Associations
(16)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (NCT06172296)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/19/2025
Initiation :
04/19/2024
Primary completion :
12/31/2029
Completion :
12/31/2029
ALK • TERT • MYCN
|
cisplatin • carboplatin • temozolomide • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • irinotecan • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • dexrazoxane
DAREONTM-9: A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With Small Cell Lung Cancer When Taken Together With a Single Agent Chemotherapy (NCT05990738)
Phase 1
Boehringer Ingelheim
Boehringer Ingelheim
Recruiting
Phase 1
Boehringer Ingelheim
Recruiting
Last update posted :
02/18/2025
Initiation :
02/14/2024
Primary completion :
01/21/2026
Completion :
11/21/2026
PD-L1
|
topotecan • obrixtamig (BI 764532)
Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors (NCT05429502)
Phase 1/2
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Recruiting
Phase 1/2
Novartis Pharmaceuticals
Recruiting
Last update posted :
02/17/2025
Initiation :
12/27/2022
Primary completion :
10/15/2027
Completion :
01/28/2028
MYCN • SMARCB1
|
IDH wild-type
|
temozolomide • Kisqali (ribociclib) • topotecan
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT (NCT04322318)
Phase 2
Children's Oncology Group
Children's Oncology Group
Recruiting
Phase 2
Children's Oncology Group
Recruiting
Last update posted :
02/13/2025
Initiation :
10/19/2020
Primary completion :
07/01/2027
Completion :
07/01/2027
TP53
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • irinotecan • vincristine • daunorubicin • topotecan
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) (NCT03126916)
Phase 3
Children's Oncology Group
Children's Oncology Group
Active, not recruiting
Phase 3
Children's Oncology Group
Active, not recruiting
Last update posted :
02/13/2025
Initiation :
05/14/2018
Primary completion :
09/30/2026
Completion :
09/30/2026
MYCN
|
MYCN amplification
|
cisplatin • Xalkori (crizotinib) • carboplatin • Lorbrena (lorlatinib) • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • busulfan • Unituxin (dinutuximab) • Azedra (iobenguane I 131) • Leukine (sargramostim) • captisol-enabled melphalan • cyclophosphamide intravenous • dexrazoxane
Comparison of Standard of Care Treatment With a Triplet Combination of Targeted Immunotherapeutic Agents (NRG-GY023) (NCT04739800)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/10/2025
Initiation :
06/10/2021
Primary completion :
01/26/2023
Completion :
06/14/2025
PD-L1 • BRCA1 • BRCA2
|
BRCA2 mutation • BRCA1 mutation
|
Avastin (bevacizumab) • Lynparza (olaparib) • Imfinzi (durvalumab) • paclitaxel • pegylated liposomal doxorubicin • topotecan • Recentin (cediranib) • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • doxorubicin liposomal
Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer (NCT02101788)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2/3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
02/27/2014
Primary completion :
04/04/2019
Completion :
10/11/2025
BRAF
|
Mekinist (trametinib) • paclitaxel • letrozole • pegylated liposomal doxorubicin • topotecan • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • Soltamox (tamoxifen citrate) • doxorubicin liposomal
Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer (NCI-2022-03215) (NCT05353439)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Suspended
Phase 1
National Cancer Institute (NCI)
Suspended
Last update posted :
01/28/2025
Initiation :
07/27/2022
Primary completion :
04/01/2025
Completion :
04/01/2025
CD4
|
Keytruda (pembrolizumab) • Tazverik (tazemetostat) • topotecan • Pembroria (pembrolizumab biosimilar)
A Study of MORAb-202 Versus Investigator's Choice Chemotherapy in Female Participants With Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer (CA116-001) (NCT05613088)
Phase 2
Bristol-Myers Squibb
Bristol-Myers Squibb
Active, not recruiting
Phase 2
Bristol-Myers Squibb
Active, not recruiting
Last update posted :
11/21/2024
Initiation :
02/01/2023
Primary completion :
06/05/2024
Completion :
10/11/2026
FOLR1
|
paclitaxel • pegylated liposomal doxorubicin • topotecan • farletuzumab ecteribulin (MORAb-202)
Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT) (NCT02114229)
Phase 2
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Active, not recruiting
Phase 2
St. Jude Children's Research Hospital
Active, not recruiting
Last update posted :
10/31/2024
Initiation :
05/14/2014
Primary completion :
09/01/2025
Completion :
09/01/2027
SMARCB1
|
SMARCA4 mutation
|
cisplatin • carboplatin • cyclophosphamide • etoposide IV • vincristine • topotecan • alisertib (MLN8237) • cyclophosphamide intravenous
A Study of N9 Chemotherapy in Children With Neuroblastoma (NCT04947501)
Phase 1
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Recruiting
Phase 1
Memorial Sloan Kettering Cancer Center
Recruiting
Last update posted :
06/11/2024
Initiation :
06/22/2021
Primary completion :
06/22/2025
Completion :
06/22/2025
MYCN
|
MYCN amplification
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • vincristine • topotecan • mesna • cyclophosphamide intravenous
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors (NCT03709680)
Phase 1/2
Pfizer
Pfizer
Active, not recruiting
Phase 1/2
Pfizer
Active, not recruiting
Last update posted :
05/22/2024
Initiation :
05/24/2019
Primary completion :
06/24/2024
Completion :
02/25/2025
EWSR1 • FUS
|
Ibrance (palbociclib) • temozolomide • cyclophosphamide • irinotecan • topotecan • cyclophosphamide intravenous
Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer (COCOS) (NCT02502266)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2/3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
05/21/2024
Initiation :
05/03/2016
Primary completion :
06/30/2024
Completion :
06/30/2024
BRCA1 • BRCA2 • BRCA • MUC16
|
BRCA2 mutation • BRCA1 mutation • BRCA mutation
|
Lynparza (olaparib) • paclitaxel • pegylated liposomal doxorubicin • topotecan • Recentin (cediranib) • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • doxorubicin liposomal
9-ING-41 in Pediatric Patients With Refractory Malignancies. (NCT04239092)
Phase 1
Actuate Therapeutics Inc.
Actuate Therapeutics Inc.
Recruiting
Phase 1
Actuate Therapeutics Inc.
Recruiting
Last update posted :
05/15/2024
Initiation :
06/05/2020
Primary completion :
12/01/2024
Completion :
12/01/2024
AFP
|
temozolomide • cyclophosphamide • irinotecan • topotecan • elraglusib (9-ING-41) • cyclophosphamide intravenous
REFRaME-O1: A Study to Investigate the Efficacy and Safety of Luveltamab Tazevibulin Versus Investigator's Choice (IC) Chemotherapy in Women With Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing FOLR1 (NCT05870748)
Phase 2/3
Sutro Biopharma, Inc.
Sutro Biopharma, Inc.
Recruiting
Phase 2/3
Sutro Biopharma, Inc.
Recruiting
Last update posted :
04/19/2024
Initiation :
07/12/2023
Primary completion :
09/01/2025
Completion :
02/01/2026
FOLR1
|
FOLR1 expression • FOLR1 positive
|
gemcitabine • paclitaxel • pegylated liposomal doxorubicin • topotecan • luveltamab tazevibulin (STRO-002) • Neulasta (pegfilgrastim)
Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma (NCI-2018-03732) (NCT03786783)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
04/17/2024
Initiation :
03/04/2019
Primary completion :
12/31/2021
Completion :
09/22/2024
MYCN • IL6 • CXCL9
|
MYCN amplification • IL6 expression
|
cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • Leukine (sargramostim) • cyclophosphamide intravenous • dexrazoxane
A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors (NCT04029688)
Phase 1/2
Hoffmann-La Roche
Hoffmann-La Roche
Active, not recruiting
Phase 1/2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
03/29/2024
Initiation :
01/27/2020
Primary completion :
12/30/2025
Completion :
12/30/2025
TP53
|
TP53 wild-type
|
Venclexta (venetoclax) • cytarabine • cyclophosphamide • topotecan • idasanutlin (RG7388) • fludarabine IV • cyclophosphamide intravenous
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer (NCT05800587)
Phase 2
Fox Chase Cancer Center
Fox Chase Cancer Center
Recruiting
Phase 2
Fox Chase Cancer Center
Recruiting
Last update posted :
03/26/2024
Initiation :
02/22/2023
Primary completion :
08/01/2028
Completion :
08/01/2029
CD4
|
carboplatin • gemcitabine • docetaxel • albumin-bound paclitaxel • pemetrexed • etoposide IV • irinotecan • topotecan • Zepzelca (lurbinectedin)
Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma (NCT01798004)
Phase 1
Children's Oncology Group
Children's Oncology Group
Active, not recruiting
Phase 1
Children's Oncology Group
Active, not recruiting
Last update posted :
03/13/2024
Initiation :
04/08/2013
Primary completion :
07/28/2015
MYCN
|
MYCN amplification • MYCN expression
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • mesna • busulfan • Neupogen (filgrastim) • cyclophosphamide intravenous
Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer (NCT01012817)
Phase 1/2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 1/2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
03/05/2024
Initiation :
11/03/2009
Primary completion :
01/13/2019
Completion :
08/30/2024
BRCA1 • BRCA2
|
BRCA mutation
|
veliparib (ABT-888) • topotecan
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers (NCT02487095)
Phase 1/2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 1/2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
03/05/2024
Initiation :
07/30/2015
Primary completion :
02/24/2021
Completion :
10/30/2025
EGFR • ALK
|
EGFR mutation • ALK translocation
|
berzosertib (M6620) • topotecan
Therapy for Children With Advanced Stage Neuroblastoma (NCT01857934)
Phase 2
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Active, not recruiting
Phase 2
St. Jude Children's Research Hospital
Active, not recruiting
Last update posted :
01/15/2024
Initiation :
07/05/2013
Primary completion :
10/21/2021
Completion :
12/01/2024
MYCN
|
MYCN amplification
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • mesna • Proleukin (aldesleukin) • busulfan • Unituxin (dinutuximab) • Leukine (sargramostim) • Neupogen (filgrastim) • cyclophosphamide intravenous • humanised dinutuximab (Hu14.18K322A)
Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin (NCT01175356)
Phase 1
Children's Oncology Group
Children's Oncology Group
Active, not recruiting
Phase 1
Children's Oncology Group
Active, not recruiting
Last update posted :
01/04/2024
Initiation :
10/04/2010
Primary completion :
09/28/2016
Completion :
09/28/2024
MYCN
|
MYCN amplification
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • busulfan • Azedra (iobenguane I 131) • cyclophosphamide intravenous
Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas (SALA-002-EW16) (NCT03600649)
Phase 1
Salarius Pharmaceuticals, LLC
Salarius Pharmaceuticals, LLC
Active, not recruiting
Phase 1
Salarius Pharmaceuticals, LLC
Active, not recruiting
Last update posted :
11/21/2023
Initiation :
06/04/2018
Primary completion :
09/01/2025
Completion :
12/01/2025
EWSR1
|
cyclophosphamide • topotecan • seclidemstat (SP2577)
Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002) (NCT02584478)
Phase 3
Advenchen Laboratories, LLC
Advenchen Laboratories, LLC
Active, not recruiting
Phase 3
Advenchen Laboratories, LLC
Active, not recruiting
Last update posted :
11/08/2023
Initiation :
12/01/2015
Primary completion :
10/01/2024
Completion :
12/01/2024
BRCA
|
BRCA mutation
|
carboplatin • paclitaxel • Focus V (anlotinib) • pegylated liposomal doxorubicin • topotecan
Comparing Standard of Care Chemotherapy Treatment to the Combination of Copanlisib and Olaparib for Recurrent Platinum Resistant Ovarian Cancer That Has Progressed Through PARP Inhibitor Therapy (NRG-GY029) (NCT05295589)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Withdrawn
Phase 2
National Cancer Institute (NCI)
Withdrawn
Last update posted :
09/26/2023
Initiation :
06/30/2022
Primary completion :
03/17/2023
Completion :
03/17/2023
BRCA1 • BRCA2 • HRD • MUC16
|
BRCA2 mutation • HRD
|
Lynparza (olaparib) • paclitaxel • Aliqopa (copanlisib) • pegylated liposomal doxorubicin • topotecan • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin)
Durvalumab and Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer (NCT04607954)
Phase 2
Mayo Clinic
Mayo Clinic
Recruiting
Phase 2
Mayo Clinic
Recruiting
Last update posted :
07/24/2023
Initiation :
12/04/2020
Primary completion :
11/01/2024
Completion :
11/01/2025
PD-L1
|
Imfinzi (durvalumab) • topotecan • Zepzelca (lurbinectedin)
Comparison of Three Treatment Regimens in Treating Patients With Relapsed or Refractory Acute Myelogenous Leukemia (NCT00005962)
Phase 2
Eastern Cooperative Oncology Group
Eastern Cooperative Oncology Group
Completed
Phase 2
Eastern Cooperative Oncology Group
Completed
Last update posted :
06/22/2023
Initiation :
10/04/2000
Primary completion :
10/01/2005
Completion :
06/01/2007
CD33
|
CD33 positive
|
cyclophosphamide • Mylotarg (gemtuzumab ozogamicin) • daunorubicin • topotecan • Leukine (sargramostim)
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression (MIRASOL) (NCT04209855)
Phase 3
ImmunoGen, Inc.
ImmunoGen, Inc.
Active, not recruiting
Phase 3
ImmunoGen, Inc.
Active, not recruiting
Last update posted :
03/06/2023
Initiation :
12/31/2019
Primary completion :
09/01/2023
Completion :
04/01/2024
FOLR1
|
FOLR1 expression
|
paclitaxel • pegylated liposomal doxorubicin • Elahere (mirvetuximab soravtansine-gynx) • topotecan • doxorubicin liposomal
Cabozantinib With Topotecan-Cyclophosphamide (NCT04661852)
Phase 1
Dana-Farber Cancer Institute
Dana-Farber Cancer Institute
Completed
Phase 1
Dana-Farber Cancer Institute
Completed
Last update posted :
02/15/2023
Initiation :
12/23/2020
Primary completion :
10/24/2022
Completion :
10/24/2022
EWSR1 • FLI1 • FUS
|
Cabometyx (cabozantinib tablet) • cyclophosphamide • Cometriq (cabozantinib capsule) • topotecan • Neulasta (pegfilgrastim) • Neupogen (filgrastim) • cyclophosphamide intravenous
Safety and Tolerability Evaluation Study of BVAC-C in Patients With HPV Type 16 or 18 Positive Cervical Cancer (BVAC-C-P1) (NCT02866006)
Phase 1/2
Cellid Co., Ltd.
Cellid Co., Ltd.
Completed
Phase 1/2
Cellid Co., Ltd.
Completed
Last update posted :
10/12/2022
Initiation :
10/01/2016
Primary completion :
12/01/2021
Completion :
06/01/2022
CD4
|
topotecan • BVAC-C
Balstilimab Versus Investigator Choice Chemotherapy in Patients With Recurrent Cervical Cancer (BRAVA) (NCT04943627)
Phase 3
Agenus Inc.
Agenus Inc.
Withdrawn
Phase 3
Agenus Inc.
Withdrawn
Last update posted :
10/05/2022
Initiation :
08/02/2021
Primary completion :
10/22/2021
Completion :
10/22/2021
PD-L1
|
PD-L1 expression
|
gemcitabine • pemetrexed • irinotecan • vinorelbine tartrate • topotecan • balstilimab (AGEN2034)
Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma (NCT00567567)
Phase 3
Children's Oncology Group
Children's Oncology Group
Completed
Phase 3
Children's Oncology Group
Completed
Last update posted :
04/28/2022
Initiation :
11/05/2007
Primary completion :
02/27/2015
Completion :
03/31/2022
CD8 • MYCN • UGT1A1 • CD4
|
MYCN amplification • UGT1A1*1*1
|
cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • topotecan • melphalan • Marqibo (vincristine liposomal) • thiotepa • Neupogen (filgrastim) • cyclophosphamide intravenous
Trial on NIraparib-TSR-042 (Dostarlimab) vs Physician's Choice CHEmotherapy in Recurrent, Ovarian, Fallopian Tube or Primary Peritoneal Cancer Patients Not Candidate for Platinum Retreatment (NItCHE) (NCT04679064)
Phase 3
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario Ag...
Recruiting
Phase 3
Fondazione Policlinico Universitario Agostino G...
Recruiting
Last update posted :
08/27/2021
Initiation :
12/01/2020
Primary completion :
01/01/2025
Completion :
01/01/2025
MUC16
|
Avastin (bevacizumab) • gemcitabine • paclitaxel • Zejula (niraparib) • Jemperli (dostarlimab-gxly) • pegylated liposomal doxorubicin • topotecan • doxorubicin liposomal
Trial on Trabectedin (ET-743) vs Clinician's Choice Chemotherapy in Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancers of BRCA Mutated or BRCAness Phenotype Patients (Mito23) (NCT02903004)
Phase 3
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario Ag...
Completed
Phase 3
Fondazione Policlinico Universitario Agostino G...
Completed
Last update posted :
08/25/2021
Initiation :
04/11/2016
Primary completion :
12/20/2018
Completion :
12/20/2018
BRCA • MUC16
|
BRCA mutation
|
carboplatin • gemcitabine • paclitaxel • pegylated liposomal doxorubicin • Yondelis (trabectedin) • topotecan • doxorubicin liposomal
Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma (NCT00499616)
Phase 3
Children's Oncology Group
Children's Oncology Group
Completed
Phase 3
Children's Oncology Group
Completed
Last update posted :
07/06/2021
Initiation :
10/08/2007
Primary completion :
06/30/2014
Completion :
06/30/2021
MYCN
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • topotecan • Neupogen (filgrastim) • cyclophosphamide intravenous
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE) (NCT03061812)
Phase 3
AbbVie
AbbVie
Completed
Phase 3
AbbVie
Completed
Last update posted :
02/23/2021
Initiation :
04/11/2017
Primary completion :
02/12/2020
Completion :
02/12/2020
DLL3
|
DLL3 expression
|
dexamethasone • topotecan • Rova-T (rovalpituzumab tesirine)
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer (FORWARD I) (NCT02631876)
Phase 3
ImmunoGen, Inc.
ImmunoGen, Inc.
Completed
Phase 3
ImmunoGen, Inc.
Completed
Last update posted :
10/14/2020
Initiation :
03/02/2016
Primary completion :
01/01/2019
Completion :
01/01/2020
FOLR1
|
FOLR1 positive
|
paclitaxel • pegylated liposomal doxorubicin • Elahere (mirvetuximab soravtansine-gynx) • topotecan • doxorubicin liposomal
Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors (AflacST1402) (NCT02390843)
Phase 1
Emory University
Emory University
Completed
Phase 1
Emory University
Completed
Last update posted :
04/03/2020
Initiation :
02/01/2015
Primary completion :
09/22/2019
Completion :
09/22/2019
STAT3 • IL6R
|
cyclophosphamide • topotecan • simvastatin • cyclophosphamide intravenous
Clinical Trial of Lurbinectedin (PM01183) in Platinum Resistant Ovarian Cancer Patients (CORAIL) (NCT02421588)
Phase 3
PharmaMar
PharmaMar
Completed
Phase 3
PharmaMar
Completed
Last update posted :
04/03/2020
Initiation :
05/01/2015
Primary completion :
10/12/2018
Completion :
10/12/2018
MUC16
|
pegylated liposomal doxorubicin • topotecan • Zepzelca (lurbinectedin)
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