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DRUG:

topotecan

i
Company:
Generic mfg.
Drug class:
Topoisomerase I inhibitor
Related drugs:
Phase 3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/19/2025
Initiation :
04/19/2024
Primary completion :
12/31/2029
Completion :
12/31/2029
ALK • TERT • MYCN
|
cisplatin • carboplatin • temozolomide • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • irinotecan • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • dexrazoxane
Phase 1
Boehringer Ingelheim
Recruiting
Last update posted :
02/18/2025
Initiation :
02/14/2024
Primary completion :
01/21/2026
Completion :
11/21/2026
PD-L1
|
topotecan • obrixtamig (BI 764532)
Phase 1/2
Novartis Pharmaceuticals
Recruiting
Last update posted :
02/17/2025
Initiation :
12/27/2022
Primary completion :
10/15/2027
Completion :
01/28/2028
MYCN • SMARCB1
|
IDH wild-type
|
temozolomide • Kisqali (ribociclib) • topotecan
Phase 2
Children's Oncology Group
Recruiting
Last update posted :
02/13/2025
Initiation :
10/19/2020
Primary completion :
07/01/2027
Completion :
07/01/2027
TP53
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • irinotecan • vincristine • daunorubicin • topotecan
Phase 3
Children's Oncology Group
Active, not recruiting
Last update posted :
02/13/2025
Initiation :
05/14/2018
Primary completion :
09/30/2026
Completion :
09/30/2026
MYCN
|
MYCN amplification
|
cisplatin • Xalkori (crizotinib) • carboplatin • Lorbrena (lorlatinib) • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • busulfan • Unituxin (dinutuximab) • Azedra (iobenguane I 131) • Leukine (sargramostim) • captisol-enabled melphalan • cyclophosphamide intravenous • dexrazoxane
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/10/2025
Initiation :
06/10/2021
Primary completion :
01/26/2023
Completion :
06/14/2025
PD-L1 • BRCA1 • BRCA2
|
BRCA2 mutation • BRCA1 mutation
|
Avastin (bevacizumab) • Lynparza (olaparib) • Imfinzi (durvalumab) • paclitaxel • pegylated liposomal doxorubicin • topotecan • Recentin (cediranib) • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • doxorubicin liposomal
Phase 2/3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
02/27/2014
Primary completion :
04/04/2019
Completion :
10/11/2025
BRAF
|
Mekinist (trametinib) • paclitaxel • letrozole • pegylated liposomal doxorubicin • topotecan • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • Soltamox (tamoxifen citrate) • doxorubicin liposomal
Phase 1
National Cancer Institute (NCI)
Suspended
Last update posted :
01/28/2025
Initiation :
07/27/2022
Primary completion :
04/01/2025
Completion :
04/01/2025
CD4
|
Keytruda (pembrolizumab) • Tazverik (tazemetostat) • topotecan • Pembroria (pembrolizumab biosimilar)
Phase 2
Bristol-Myers Squibb
Active, not recruiting
Last update posted :
11/21/2024
Initiation :
02/01/2023
Primary completion :
06/05/2024
Completion :
10/11/2026
FOLR1
|
paclitaxel • pegylated liposomal doxorubicin • topotecan • farletuzumab ecteribulin (MORAb-202)
Phase 2
St. Jude Children's Research Hospital
Active, not recruiting
Last update posted :
10/31/2024
Initiation :
05/14/2014
Primary completion :
09/01/2025
Completion :
09/01/2027
SMARCB1
|
SMARCA4 mutation
|
cisplatin • carboplatin • cyclophosphamide • etoposide IV • vincristine • topotecan • alisertib (MLN8237) • cyclophosphamide intravenous
Phase 1
Memorial Sloan Kettering Cancer Center
Recruiting
Last update posted :
06/11/2024
Initiation :
06/22/2021
Primary completion :
06/22/2025
Completion :
06/22/2025
MYCN
|
MYCN amplification
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • vincristine • topotecan • mesna • cyclophosphamide intravenous
Phase 1/2
Pfizer
Active, not recruiting
Last update posted :
05/22/2024
Initiation :
05/24/2019
Primary completion :
06/24/2024
Completion :
02/25/2025
EWSR1 • FUS
|
Ibrance (palbociclib) • temozolomide • cyclophosphamide • irinotecan • topotecan • cyclophosphamide intravenous
Phase 2/3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
05/21/2024
Initiation :
05/03/2016
Primary completion :
06/30/2024
Completion :
06/30/2024
BRCA1 • BRCA2 • BRCA • MUC16
|
BRCA2 mutation • BRCA1 mutation • BRCA mutation
|
Lynparza (olaparib) • paclitaxel • pegylated liposomal doxorubicin • topotecan • Recentin (cediranib) • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin) • doxorubicin liposomal
Phase 1
Actuate Therapeutics Inc.
Recruiting
Last update posted :
05/15/2024
Initiation :
06/05/2020
Primary completion :
12/01/2024
Completion :
12/01/2024
AFP
|
temozolomide • cyclophosphamide • irinotecan • topotecan • elraglusib (9-ING-41) • cyclophosphamide intravenous
Phase 2/3
Sutro Biopharma, Inc.
Recruiting
Last update posted :
04/19/2024
Initiation :
07/12/2023
Primary completion :
09/01/2025
Completion :
02/01/2026
FOLR1
|
FOLR1 expression • FOLR1 positive
|
gemcitabine • paclitaxel • pegylated liposomal doxorubicin • topotecan • luveltamab tazevibulin (STRO-002) • Neulasta (pegfilgrastim)
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
04/17/2024
Initiation :
03/04/2019
Primary completion :
12/31/2021
Completion :
09/22/2024
MYCN • IL6 • CXCL9
|
MYCN amplification • IL6 expression
|
cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • Leukine (sargramostim) • cyclophosphamide intravenous • dexrazoxane
Phase 1/2
Hoffmann-La Roche
Active, not recruiting
Last update posted :
03/29/2024
Initiation :
01/27/2020
Primary completion :
12/30/2025
Completion :
12/30/2025
TP53
|
TP53 wild-type
|
Venclexta (venetoclax) • cytarabine • cyclophosphamide • topotecan • idasanutlin (RG7388) • fludarabine IV • cyclophosphamide intravenous
Phase 2
Fox Chase Cancer Center
Recruiting
Last update posted :
03/26/2024
Initiation :
02/22/2023
Primary completion :
08/01/2028
Completion :
08/01/2029
CD4
|
carboplatin • gemcitabine • docetaxel • albumin-bound paclitaxel • pemetrexed • etoposide IV • irinotecan • topotecan • Zepzelca (lurbinectedin)
Phase 1
Children's Oncology Group
Active, not recruiting
Last update posted :
03/13/2024
Initiation :
04/08/2013
Primary completion :
07/28/2015
MYCN
|
MYCN amplification • MYCN expression
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • mesna • busulfan • Neupogen (filgrastim) • cyclophosphamide intravenous
Phase 1/2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
03/05/2024
Initiation :
11/03/2009
Primary completion :
01/13/2019
Completion :
08/30/2024
BRCA1 • BRCA2
|
BRCA mutation
|
veliparib (ABT-888) • topotecan
Phase 1/2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
03/05/2024
Initiation :
07/30/2015
Primary completion :
02/24/2021
Completion :
10/30/2025
EGFR • ALK
|
EGFR mutation • ALK translocation
|
berzosertib (M6620) • topotecan
Phase 2
St. Jude Children's Research Hospital
Active, not recruiting
Last update posted :
01/15/2024
Initiation :
07/05/2013
Primary completion :
10/21/2021
Completion :
12/01/2024
MYCN
|
MYCN amplification
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • mesna • Proleukin (aldesleukin) • busulfan • Unituxin (dinutuximab) • Leukine (sargramostim) • Neupogen (filgrastim) • cyclophosphamide intravenous • humanised dinutuximab (Hu14.18K322A)
Phase 1
Children's Oncology Group
Active, not recruiting
Last update posted :
01/04/2024
Initiation :
10/04/2010
Primary completion :
09/28/2016
Completion :
09/28/2024
MYCN
|
MYCN amplification
|
cisplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • busulfan • Azedra (iobenguane I 131) • cyclophosphamide intravenous
Phase 1
Salarius Pharmaceuticals, LLC
Active, not recruiting
Last update posted :
11/21/2023
Initiation :
06/04/2018
Primary completion :
09/01/2025
Completion :
12/01/2025
EWSR1
|
cyclophosphamide • topotecan • seclidemstat (SP2577)
Phase 3
Advenchen Laboratories, LLC
Active, not recruiting
Last update posted :
11/08/2023
Initiation :
12/01/2015
Primary completion :
10/01/2024
Completion :
12/01/2024
BRCA
|
BRCA mutation
|
carboplatin • paclitaxel • Focus V (anlotinib) • pegylated liposomal doxorubicin • topotecan
Phase 2
National Cancer Institute (NCI)
Withdrawn
Last update posted :
09/26/2023
Initiation :
06/30/2022
Primary completion :
03/17/2023
Completion :
03/17/2023
BRCA1 • BRCA2 • HRD • MUC16
|
BRCA2 mutation • HRD
|
Lynparza (olaparib) • paclitaxel • Aliqopa (copanlisib) • pegylated liposomal doxorubicin • topotecan • Myocet (non-pegylated liposomal doxorubicin) • Duomeisu (pegylated liposomal doxorubicin)
Phase 2
Mayo Clinic
Recruiting
Last update posted :
07/24/2023
Initiation :
12/04/2020
Primary completion :
11/01/2024
Completion :
11/01/2025
PD-L1
|
Imfinzi (durvalumab) • topotecan • Zepzelca (lurbinectedin)
Phase 2
Eastern Cooperative Oncology Group
Completed
Last update posted :
06/22/2023
Initiation :
10/04/2000
Primary completion :
10/01/2005
Completion :
06/01/2007
CD33
|
CD33 positive
|
cyclophosphamide • Mylotarg (gemtuzumab ozogamicin) • daunorubicin • topotecan • Leukine (sargramostim)
Phase 3
ImmunoGen, Inc.
Active, not recruiting
Last update posted :
03/06/2023
Initiation :
12/31/2019
Primary completion :
09/01/2023
Completion :
04/01/2024
FOLR1
|
FOLR1 expression
|
paclitaxel • pegylated liposomal doxorubicin • Elahere (mirvetuximab soravtansine-gynx) • topotecan • doxorubicin liposomal
Phase 1
Dana-Farber Cancer Institute
Completed
Last update posted :
02/15/2023
Initiation :
12/23/2020
Primary completion :
10/24/2022
Completion :
10/24/2022
EWSR1 • FLI1 • FUS
|
Cabometyx (cabozantinib tablet) • cyclophosphamide • Cometriq (cabozantinib capsule) • topotecan • Neulasta (pegfilgrastim) • Neupogen (filgrastim) • cyclophosphamide intravenous
Phase 1/2
Cellid Co., Ltd.
Completed
Last update posted :
10/12/2022
Initiation :
10/01/2016
Primary completion :
12/01/2021
Completion :
06/01/2022
CD4
|
topotecan • BVAC-C
Phase 3
Agenus Inc.
Withdrawn
Last update posted :
10/05/2022
Initiation :
08/02/2021
Primary completion :
10/22/2021
Completion :
10/22/2021
PD-L1
|
PD-L1 expression
|
gemcitabine • pemetrexed • irinotecan • vinorelbine tartrate • topotecan • balstilimab (AGEN2034)
Phase 3
Children's Oncology Group
Completed
Last update posted :
04/28/2022
Initiation :
11/05/2007
Primary completion :
02/27/2015
Completion :
03/31/2022
CD8 • MYCN • UGT1A1 • CD4
|
MYCN amplification • UGT1A1*1*1
|
cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • topotecan • melphalan • Marqibo (vincristine liposomal) • thiotepa • Neupogen (filgrastim) • cyclophosphamide intravenous
Phase 3
Fondazione Policlinico Universitario Agostino G...
Recruiting
Last update posted :
08/27/2021
Initiation :
12/01/2020
Primary completion :
01/01/2025
Completion :
01/01/2025
MUC16
|
Avastin (bevacizumab) • gemcitabine • paclitaxel • Zejula (niraparib) • Jemperli (dostarlimab-gxly) • pegylated liposomal doxorubicin • topotecan • doxorubicin liposomal
Phase 3
Fondazione Policlinico Universitario Agostino G...
Completed
Last update posted :
08/25/2021
Initiation :
04/11/2016
Primary completion :
12/20/2018
Completion :
12/20/2018
BRCA • MUC16
|
BRCA mutation
|
carboplatin • gemcitabine • paclitaxel • pegylated liposomal doxorubicin • Yondelis (trabectedin) • topotecan • doxorubicin liposomal
Phase 3
Children's Oncology Group
Completed
Last update posted :
07/06/2021
Initiation :
10/08/2007
Primary completion :
06/30/2014
Completion :
06/30/2021
MYCN
|
carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • topotecan • Neupogen (filgrastim) • cyclophosphamide intravenous
Phase 3
AbbVie
Completed
Last update posted :
02/23/2021
Initiation :
04/11/2017
Primary completion :
02/12/2020
Completion :
02/12/2020
DLL3
|
DLL3 expression
|
dexamethasone • topotecan • Rova-T (rovalpituzumab tesirine)
Phase 3
ImmunoGen, Inc.
Completed
Last update posted :
10/14/2020
Initiation :
03/02/2016
Primary completion :
01/01/2019
Completion :
01/01/2020
FOLR1
|
FOLR1 positive
|
paclitaxel • pegylated liposomal doxorubicin • Elahere (mirvetuximab soravtansine-gynx) • topotecan • doxorubicin liposomal
Phase 1
Emory University
Completed
Last update posted :
04/03/2020
Initiation :
02/01/2015
Primary completion :
09/22/2019
Completion :
09/22/2019
STAT3 • IL6R
|
cyclophosphamide • topotecan • simvastatin • cyclophosphamide intravenous
Phase 3
PharmaMar
Completed
Last update posted :
04/03/2020
Initiation :
05/01/2015
Primary completion :
10/12/2018
Completion :
10/12/2018
MUC16
|
pegylated liposomal doxorubicin • topotecan • Zepzelca (lurbinectedin)