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DRUG:
tinostamustine (EDO-S101)
i
Other names:
EDO-S101, EDO S101, EDO-S 101, EDO-S-101, NL-101, bendamustine-vorinostat fusion molecule, bendamustine + vorinostat, vorinostat + bendamustine
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News alerts, weekly reports and conference planners
Associations
News
Trials
Company:
Mundipharma
Drug class:
HDAC inhibitor
Related drugs:
‹
chidamide (23)
vorinostat (19)
panobinostat (15)
romidepsin (9)
entinostat (9)
CUDC-907 (8)
OKI-179 (4)
SB939 (4)
belinostat (2)
CG-781 (2)
MGCD0103 (2)
REC-2282 (1)
4SC-202 (1)
JNJ 26481585 (1)
CUDC-101 (0)
givinostat (0)
resminostat (0)
RG2833 (0)
sulforafan alfadex (0)
CKD-581 (0)
histone deacetylase inhibitors/hypomethylating agents (0)
CG-745 (0)
kt-3000 series (0)
kt-3283 (0)
VRx-3996 (0)
MTX110 (0)
SHP-141 (0)
OBP-801 (0)
VTR-297 (0)
CXD101 (0)
chidamide (23)
vorinostat (19)
panobinostat (15)
romidepsin (9)
entinostat (9)
CUDC-907 (8)
OKI-179 (4)
SB939 (4)
belinostat (2)
CG-781 (2)
MGCD0103 (2)
REC-2282 (1)
4SC-202 (1)
JNJ 26481585 (1)
CUDC-101 (0)
givinostat (0)
resminostat (0)
RG2833 (0)
sulforafan alfadex (0)
CKD-581 (0)
histone deacetylase inhibitors/hypomethylating agents (0)
CG-745 (0)
kt-3000 series (0)
kt-3283 (0)
VRx-3996 (0)
MTX110 (0)
SHP-141 (0)
OBP-801 (0)
VTR-297 (0)
CXD101 (0)
›
Associations
News
Trials
Phase
Status
Apply
Phase
Status
Apply
Tinostamustine With or Without Radiation Therapy in Treating Patients With Newly Diagnosed MGMT-Unmethylated Glioblastoma (NCI-2018-00872) (NCT03452930)
Phase 1
M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
Active, not recruiting
Phase 1
M.D. Anderson Cancer Center
Active, not recruiting
Last update posted :
05/15/2024
Initiation :
08/13/2018
Primary completion :
12/30/2024
Completion :
12/30/2024
MGMT
|
IDH wild-type
|
tinostamustine (EDO-S101)
Study of Tinostamustine for Adjuvant Treatment of Glioblastoma (NCT05432375)
Phase 1
Mundipharma Research Limited
Mundipharma Research Limited
Active, not recruiting
Phase 1
Mundipharma Research Limited
Active, not recruiting
Last update posted :
01/23/2024
Initiation :
07/01/2022
Primary completion :
07/01/2024
Completion :
11/30/2024
MGMT
|
IDH wild-type
|
temozolomide • tinostamustine (EDO-S101)
A Phase Ib Combination Study of Rituximab, TinostamustinEAnd CHeckpoint Inhibition With Pembrolizumab in Relapsed/Refractory DLBCL (NCT04279938)
Phase 1
Royal Marsden NHS Foundation Trust
Royal Marsden NHS Foundation Trust
Withdrawn
Phase 1
Royal Marsden NHS Foundation Trust
Withdrawn
Last update posted :
02/21/2020
Initiation :
09/01/2018
Primary completion :
03/01/2020
Completion :
01/01/2021
CD20
|
Keytruda (pembrolizumab) • Rituxan (rituximab) • tinostamustine (EDO-S101)
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