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    CANCER:

    Thymus Cancer

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    A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers (NCT05544929)
    Phase 1
    Novartis Pharmaceuticals
    Recruiting
    Last update posted :
    02/06/2025
    Initiation :
    10/26/2022
    Primary completion :
    02/20/2026
    Completion :
    02/20/2026
    MSI
    |
    MSI-H/dMMR
    |
    Keytruda (pembrolizumab) • Tevimbra (tislelizumab-jsgr) • KFA115
    A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy (NCT03076554)
    Phase 2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    02/04/2025
    Initiation :
    04/19/2017
    Primary completion :
    06/30/2025
    Completion :
    06/30/2026
    PD-L1
    |
    Bavencio (avelumab)
    Phase I/II Eval Safety & Prelim Activity Nivolumab Comb W/Vorolanib Pts W/Refractory Thoracic Tumors (CA209-982) (NCT03583086)
    Phase 1/2
    Vanderbilt-Ingram Cancer Center
    Completed
    Last update posted :
    10/08/2024
    Initiation :
    07/10/2018
    Primary completion :
    02/21/2024
    Completion :
    04/27/2024
    EGFR • PD-L1 • BRAF • ROS1
    |
    Opdivo (nivolumab) • Fumena (vorolanib)
    Combination of Pembrolizumab and Lenvatinib, in Pre-treated Thymic CArcinoma paTIents (PECATI) (NCT04710628)
    Phase 2
    MedSIR
    Active, not recruiting
    Last update posted :
    08/08/2024
    Initiation :
    09/21/2021
    Primary completion :
    07/01/2024
    Completion :
    01/31/2026
    PD-L1
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • Lenvima (lenvatinib)
    Selective TrkA Inhibitor VMD-928 to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma (NCT03556228)
    Phase 1
    VM Oncology, LLC
    Recruiting
    Last update posted :
    05/31/2024
    Initiation :
    06/08/2018
    Primary completion :
    12/01/2025
    Completion :
    06/01/2026
    NTRK1
    |
    NTRK1 fusion • NTRK1 mutation • NTRK expression
    |
    VMD-928
    Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies (NCT01306045)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    04/09/2024
    Initiation :
    02/08/2011
    Primary completion :
    02/12/2014
    Completion :
    12/31/2024
    EGFR • BRAF
    |
    EGFR mutation
    |
    erlotinib • sunitinib • lapatinib • Koselugo (selumetinib) • MK-2206
    Pembrolizumab and Sunitinib Malate in Treating Participants With Refractory Metastatic or Unresectable Thymic Cancer (NCI-2018-00192) (NCT03463460)
    Phase 2
    Dwight Owen
    Suspended
    Last update posted :
    03/15/2024
    Initiation :
    06/19/2018
    Primary completion :
    12/31/2024
    Completion :
    12/31/2025
    PD-L1
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • sunitinib
    IL-8+ naïve T Cells as a Biomarker for Thymoma Identification (NCT05255965)
    Phase N/A
    Shanghai Zhongshan Hospital
    Recruiting
    Last update posted :
    02/19/2024
    Initiation :
    09/01/2022
    Primary completion :
    12/31/2024
    Completion :
    12/31/2025
    CXCL8
    177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours (LuPARP) (NCT04375267)
    Phase 1
    Vastra Gotaland Region
    Active, not recruiting
    Last update posted :
    11/14/2023
    Initiation :
    04/23/2020
    Primary completion :
    06/30/2024
    Completion :
    06/30/2024
    SSTR
    |
    SSTR positive
    |
    Lynparza (olaparib) • Lutathera (lutetium Lu 177 dotatate) • Solucin (177Lu-edotreotide)
    Efficacy and Safety of Radiotherapy Compared to Everolimus in Somatostatin Receptor Positive Neuroendocrine Tumors of the Lung and Thymus. (LEVEL) (NCT05918302)
    Phase 3
    Grupo Espanol de Tumores Neuroendocrinos
    Recruiting
    Last update posted :
    11/02/2023
    Initiation :
    10/27/2023
    Primary completion :
    03/01/2028
    Completion :
    07/01/2028
    SSTR
    |
    everolimus • Solucin (177Lu-edotreotide)
    First-line CBDCA/PTX/LEN/Pembrolizumab Combination for Previously Untreated Advanced or Recurrent Thymic Carcinomas (Artemis) (NCT05832827)
    Phase 2
    National Cancer Center, Japan
    Recruiting
    Last update posted :
    10/20/2023
    Initiation :
    09/04/2023
    Primary completion :
    12/31/2025
    Completion :
    06/30/2028
    KIT • CD5 • TP63
    |
    CD5 positive
    |
    Keytruda (pembrolizumab) • carboplatin • paclitaxel • Lenvima (lenvatinib)
    Application of 68Ga-Pentixafor PET/CT for Thymoma (NCT06086327)
    Phase 1
    Peking Union Medical College Hospital
    Recruiting
    Last update posted :
    10/17/2023
    Initiation :
    06/22/2023
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    CXCR4
    |
    CXCR4 expression
    Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers (FAPI PET RDRC) (NCT04459273)
    Phase 1
    Jonsson Comprehensive Cancer Center
    Recruiting
    Last update posted :
    10/13/2023
    Initiation :
    08/27/2020
    Primary completion :
    07/01/2024
    Completion :
    07/01/2025
    FAP
    |
    FAP expression
    Molecular Analysis of Thoracic Malignancies (NCT01385722)
    Phase N/A
    Stanford University
    Enrolling by invitation
    Last update posted :
    07/19/2023
    Initiation :
    08/01/2011
    Primary completion :
    06/01/2031
    Completion :
    06/01/2031
    BRAF
    Phase-II Study of Lu177DOTATOC in Adults With STTR(+)Pulmonary, Pheochromocytoma, Paraganglioma, Unknown Primary, Thymus NETs (PUTNET), or Any Other Non-.GEP-NET. (NCT04276597)
    Phase 2
    Excel Diagnostics and Nuclear Oncology Center
    Withdrawn
    Last update posted :
    03/10/2023
    Initiation :
    03/04/2020
    Primary completion :
    07/15/2021
    Completion :
    07/15/2021
    SSTR
    |
    SSTR positive
    |
    Solucin (177Lu-edotreotide)
    Nivolumab in Patients With Type B3 Thymoma and Thymic Carcinoma (NIVOTHYM) (NCT03134118)
    Phase 2
    European Organisation for Research and Treatmen...
    Active, not recruiting
    Last update posted :
    02/21/2023
    Initiation :
    04/11/2018
    Primary completion :
    12/01/2023
    Completion :
    07/01/2024
    PD-L1
    |
    PD-L1 expression
    |
    Opdivo (nivolumab)
    A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors (DUET-2) (NCT03517488)
    Phase 1
    Xencor, Inc.
    Completed
    Last update posted :
    12/01/2022
    Initiation :
    07/10/2018
    Primary completion :
    06/01/2022
    Completion :
    09/06/2022
    HER-2 • ER • PGR • MSI
    |
    MSI-H/dMMR • HER-2 negative
    |
    vudalimab (XmAb717)
    Study of Everolimus in Patients With Thymoma and Thymic Carcinoma Previously Treated With Chemotherapy (NCT02049047)
    Phase 2
    Armando Santoro, MD
    Completed
    Last update posted :
    09/10/2022
    Initiation :
    02/01/2011
    Primary completion :
    04/01/2014
    Completion :
    01/01/2019
    PTEN • mTOR
    |
    everolimus
    Chemotherapy Combined With Pembrolizumab in Treating Patients With Thymoma and Thymic Carcinoma (NCT04554524)
    Phase 4
    Tang-Du Hospital
    Recruiting
    Last update posted :
    10/28/2020
    Initiation :
    08/27/2020
    Primary completion :
    07/30/2024
    Completion :
    07/30/2024
    PD-L1
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • albumin-bound paclitaxel
    A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor (NCT02607631)
    Phase 2
    Samsung Medical Center
    Completed
    Last update posted :
    07/09/2020
    Initiation :
    11/01/2015
    Primary completion :
    02/01/2018
    Completion :
    08/01/2018
    PD-L1
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • cisplatin
    Pembrolizumab and Epacadostat in Patients With Thymic Carcinoma (NCT02364076)
    Phase 2
    Georgetown University
    Unknown status
    Last update posted :
    12/13/2019
    Initiation :
    03/01/2015
    Primary completion :
    06/01/2019
    Completion :
    12/01/2021
    PD-L1
    |
    Keytruda (pembrolizumab) • epacadostat (INCB024360)
    Regulation of LncRNA For Breg in Patients With Thymoma and Autoimmune Diseases (NCT02948855)
    Phase N/A
    Tianjin Medical University Cancer Institute and...
    Withdrawn
    Last update posted :
    05/18/2018
    Initiation :
    10/01/2016
    Primary completion :
    05/01/2018
    Completion :
    05/01/2018
    NOTCH2