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    DRUG:

    thiotepa

    i
    Company:
    Generic mfg.
    Drug class:
    DNA synthesis inhibitor, Alkylating agent
    Related drugs:
    Apply
    Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma (NCT06172296)
    Phase 3
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    02/19/2025
    Initiation :
    04/19/2024
    Primary completion :
    12/31/2029
    Completion :
    12/31/2029
    ALK • TERT • MYCN
    |
    cisplatin • carboplatin • temozolomide • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • irinotecan • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • dexrazoxane
    Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS (NCT04708054)
    Phase 2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    02/18/2025
    Initiation :
    10/21/2021
    Primary completion :
    12/31/2027
    Completion :
    12/31/2027
    KRAS • NRAS • DNMT3A • NF1 • RUNX1 • ASXL1 • PTPN1
    |
    TP53 mutation • KRAS mutation • NRAS mutation • RAS mutation
    |
    Venclexta (venetoclax) • cladribine • fludarabine IV • thiotepa • busulfan
    Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL) (NCT03126916)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    02/13/2025
    Initiation :
    05/14/2018
    Primary completion :
    09/30/2026
    Completion :
    09/30/2026
    MYCN
    |
    MYCN amplification
    |
    cisplatin • Xalkori (crizotinib) • carboplatin • Lorbrena (lorlatinib) • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • busulfan • Unituxin (dinutuximab) • Azedra (iobenguane I 131) • Leukine (sargramostim) • captisol-enabled melphalan • cyclophosphamide intravenous • dexrazoxane
    A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT (NCT04684368)
    Phase 2
    Children's Oncology Group
    Recruiting
    Last update posted :
    02/13/2025
    Initiation :
    07/13/2021
    Primary completion :
    12/21/2029
    Completion :
    12/21/2029
    NF1
    |
    AFP elevation
    |
    carboplatin • cyclophosphamide • ifosfamide • etoposide IV • mesna • thiotepa • Neulasta (pegfilgrastim) • Fulphila (pegfilgrastim-jmdb) • Neupogen (filgrastim) • Udenyca (pegfilgrastim-cbqv) • Ziextenzo (pegfilgrastim-bmez) • cyclophosphamide intravenous
    Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome (NCT05457556)
    Phase 3
    Children's Oncology Group
    Recruiting
    Last update posted :
    02/13/2025
    Initiation :
    03/15/2023
    Primary completion :
    12/01/2027
    Completion :
    12/01/2027
    FLT3 • ABL1 • BCR • NPM1 • HLA-DRB1 • CEBPA • HLA-DQB1 • HLA-B • HLA-C
    |
    FLT3-ITD mutation
    |
    Rituxan (rituximab) • cyclophosphamide • methotrexate • melphalan • Truxima (rituximab-abbs) • fludarabine IV • thiotepa • busulfan • Mabtas (rituximab biosimilar)
    Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases (NCT06013423)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    01/31/2025
    Initiation :
    07/23/2024
    Primary completion :
    10/31/2031
    Completion :
    10/31/2032
    KMT2A • HLA-DRB1 • HLA-B
    |
    MLL rearrangement
    |
    cyclophosphamide • fludarabine IV • thiotepa • cyclosporin A microemulsion
    CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant (CNS-PHLAT) (NCT06687772)
    Phase 2
    Washington University School of Medicine
    Recruiting
    Last update posted :
    01/22/2025
    Initiation :
    01/16/2025
    Primary completion :
    07/31/2027
    Completion :
    07/31/2029
    CD34
    |
    carmustine • melphalan • thiotepa
    Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) (NCI-2019-03188) (NCT03970096)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    05/30/2024
    Initiation :
    11/19/2019
    Primary completion :
    12/31/2026
    Completion :
    12/31/2028
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    cyclophosphamide • sirolimus • fludarabine IV • thiotepa • busulfan • cyclosporin A microemulsion • cyclophosphamide intravenous • methotrexate IV
    High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) (HR-NBL2) (NCT04221035)
    Phase 3
    Gustave Roussy, Cancer Campus, Grand Paris
    Recruiting
    Last update posted :
    05/15/2024
    Initiation :
    11/05/2019
    Primary completion :
    11/01/2026
    Completion :
    11/01/2032
    MYCN • MYCL
    |
    MYCN amplification • MYCL amplification
    |
    cisplatin • carboplatin • temozolomide • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • irinotecan • vincristine • dacarbazine • melphalan • thiotepa • Qarziba (dinutuximab beta) • busulfan • cyclophosphamide intravenous • vindesine
    A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant (NCT04872595)
    Phase 2
    Memorial Sloan Kettering Cancer Center
    Active, not recruiting
    Last update posted :
    04/18/2024
    Initiation :
    04/30/2021
    Primary completion :
    04/01/2025
    Completion :
    04/01/2025
    TP53 • HLA-DRB1 • CD34 • CD4
    |
    TP53 mutation
    |
    cyclophosphamide • melphalan • fludarabine IV • thiotepa • busulfan
    Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma (NCI-2018-03732) (NCT03786783)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    04/17/2024
    Initiation :
    03/04/2019
    Primary completion :
    12/31/2021
    Completion :
    09/22/2024
    MYCN • IL6 • CXCL9
    |
    MYCN amplification • IL6 expression
    |
    cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • daunorubicin • topotecan • melphalan • thiotepa • Qarziba (dinutuximab beta) • Unituxin (dinutuximab) • Leukine (sargramostim) • cyclophosphamide intravenous • dexrazoxane
    CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML (NCT04151706)
    Phase 2
    Stanford University
    Suspended
    Last update posted :
    04/16/2024
    Initiation :
    02/27/2020
    Primary completion :
    02/01/2025
    Completion :
    02/01/2026
    HLA-DRB1
    |
    cyclophosphamide • fludarabine IV • thiotepa • busulfan • cyclophosphamide intravenous
    Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults (NCT04530487)
    Phase 2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    04/11/2024
    Initiation :
    08/19/2020
    Primary completion :
    05/09/2025
    Completion :
    05/09/2025
    HLA-DRB1 • HLA-B • HLA-C
    |
    etoposide IV • melphalan • fludarabine IV • thiotepa • cyclosporin A microemulsion
    CD34+ Transplants for Leukemia and Lymphoma (NCT05565105)
    Phase 2
    Guenther Koehne
    Not yet recruiting
    Last update posted :
    04/09/2024
    Initiation :
    06/01/2024
    Primary completion :
    06/01/2031
    Completion :
    06/01/2031
    CD34
    |
    cyclophosphamide • melphalan • fludarabine IV • thiotepa • busulfan
    Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant (NCI-2018-01752) (NCT03779854)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    03/25/2024
    Initiation :
    08/29/2019
    Primary completion :
    12/31/2025
    Completion :
    12/31/2025
    HLA-DRB1 • HLA-B • HLA-C
    |
    cyclophosphamide • methotrexate • fludarabine IV • thiotepa • busulfan • cyclophosphamide intravenous • methotrexate IV
    Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children (NCT01858740)
    Phase 2
    Fred Hutchinson Cancer Center
    Completed
    Last update posted :
    03/12/2024
    Initiation :
    04/10/2014
    Primary completion :
    01/30/2023
    Completion :
    07/30/2023
    HLA-DRB1 • HLA-B • HLA-C
    |
    methotrexate • fludarabine IV • thiotepa • methotrexate IV
    Auto Transplant for High Risk or Relapsed Solid or CNS Tumors (NCT01505569)
    Phase N/A
    Masonic Cancer Center, University of Minnesota
    Completed
    Last update posted :
    02/26/2024
    Initiation :
    10/20/2011
    Primary completion :
    02/01/2024
    Completion :
    02/01/2024
    MYCN • CD34
    |
    LDH elevation • MYCN expression
    |
    cisplatin • carboplatin • paclitaxel • ifosfamide • etoposide IV • melphalan • mesna • thiotepa • busulfan
    US Study of ECT-001-CB in Pediatric and Young Adult Patients With High-Risk Myeloid Malignancies (NCT04990323)
    Phase 1/2
    ExCellThera inc.
    Recruiting
    Last update posted :
    02/19/2024
    Initiation :
    12/01/2021
    Primary completion :
    06/01/2026
    Completion :
    06/01/2026
    HLA-DRB1 • CD34
    |
    cyclophosphamide • clofarabine • fludarabine IV • thiotepa • busulfan • cyclophosphamide intravenous • dorocubicel (UM171 cell therapy)
    Reduced Intensity Allogeneic HCT in Advanced Hematologic Malignancies w/T-Cell Depleted Graft (NCT05088356)
    Phase 1
    Stanford University
    Recruiting
    Last update posted :
    02/19/2024
    Initiation :
    09/07/2021
    Primary completion :
    12/01/2025
    Completion :
    12/01/2025
    HLA-DRB1 • HLA-B • HLA-C
    |
    Jakafi (ruxolitinib) • cyclophosphamide • melphalan • fludarabine IV • thiotepa • Neupogen (filgrastim) • plerixafor
    Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes (NCI-2017-02205) (NCT03399773)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    02/15/2024
    Initiation :
    05/10/2022
    Primary completion :
    10/08/2024
    Completion :
    06/30/2026
    HLA-DRB1 • CD34 • HLA-B
    |
    cyclophosphamide • fludarabine IV • thiotepa • Omisirge (omidubicel) • cyclophosphamide intravenous • dilanubicel (DVX101)
    Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD (NCT02220985)
    Phase 2
    Fred Hutchinson Cancer Center
    Active, not recruiting
    Last update posted :
    02/08/2024
    Initiation :
    02/03/2015
    Primary completion :
    04/01/2025
    Completion :
    04/01/2025
    HLA-DRB1 • HLA-B • HLA-C
    |
    cyclophosphamide • methotrexate • fludarabine IV • thiotepa • cyclophosphamide intravenous • methotrexate IV
    Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders (NCT03980769)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    02/05/2024
    Initiation :
    05/05/2021
    Primary completion :
    07/01/2027
    Completion :
    07/01/2027
    HLA-DRB1 • CD34 • HLA-DQB1 • HLA-B • HLA-C
    |
    fludarabine IV • thiotepa • busulfan • Grafapex (treosulfan)
    TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies (HAP2HCT) (NCT03849651)
    Phase 2
    St. Jude Children's Research Hospital
    Active, not recruiting
    Last update posted :
    01/19/2024
    Initiation :
    01/31/2019
    Primary completion :
    07/01/2024
    Completion :
    07/01/2025
    FLT3 • RUNX1 • KMT2A • ETV6 • WT1 • CREBBP • NUP98 • NSD1 • HOXA9 • NUP214 • CBFA2T3 • GLIS2 • KAT6A • KDM5A • DEK • AFDN • MLLT10
    |
    FLT3-ITD mutation • WT1 mutation • MLL fusion • NUP98-NSD1 fusion
    |
    cyclophosphamide • Blincyto (blinatumomab) • melphalan • fludarabine IV • mesna • thiotepa • Neupogen (filgrastim) • cyclophosphamide intravenous
    Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation (NCT01746849)
    Phase 2
    Memorial Sloan Kettering Cancer Center
    Active, not recruiting
    Last update posted :
    01/05/2024
    Initiation :
    12/01/2012
    Primary completion :
    12/01/2024
    Completion :
    12/01/2024
    CD34 • CD4
    |
    Chr t(15;17)
    |
    cyclophosphamide • Firmagon (degarelix) • thiotepa • leuprolide acetate for depot suspension • Kepivance (palifermin) • cyclophosphamide intravenous
    Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease (NCT00719888)
    Phase 2
    Fred Hutchinson Cancer Center
    Active, not recruiting
    Last update posted :
    01/05/2024
    Initiation :
    11/18/2005
    Primary completion :
    12/22/2023
    Completion :
    12/22/2024
    HLA-DRB1 • HLA-B
    |
    cyclophosphamide • fludarabine IV • thiotepa • cyclosporin A microemulsion • cyclophosphamide intravenous
    IS-free Treg HaploHCT (NCT04678401)
    Phase 1
    Dana-Farber Cancer Institute
    Recruiting
    Last update posted :
    01/04/2024
    Initiation :
    01/12/2021
    Primary completion :
    10/31/2025
    Completion :
    10/31/2027
    TP53 • HLA-DRB1
    |
    TP53 mutation
    |
    cyclophosphamide • fludarabine IV • mesna • thiotepa • cyclophosphamide intravenous
    Reduced-Intensity Conditioning (RIC) and Myeloablative Conditioning (MAC) for HSCT in AML/MDS (NCT02626715)
    Phase 2
    Randy Windreich
    Completed
    Last update posted :
    12/19/2023
    Initiation :
    09/04/2015
    Primary completion :
    04/12/2023
    Completion :
    04/12/2023
    FLT3 • CD34
    |
    FLT3 positive
    |
    Campath (alemtuzumab) • melphalan • fludarabine IV • hydroxyurea • thiotepa • busulfan
    Thiotepa Plus Fludarabine+ Melphalan as the Preparative Regime for Alternative Donor Transplantation (NCT03342196)
    Phase 2
    Case Comprehensive Cancer Center
    Active, not recruiting
    Last update posted :
    12/11/2023
    Initiation :
    03/21/2018
    Primary completion :
    06/09/2024
    Completion :
    06/09/2025
    FLT3
    |
    FLT3 mutation
    |
    melphalan • fludarabine IV • thiotepa • Kepivance (palifermin) • captisol-enabled melphalan
    TEAM (Thiotepa, Etoposide, Cytosar, Melphalan ) for AutoSCT in Lymphoma (NCT03346096)
    Phase 2
    Sheba Medical Center
    Active, not recruiting
    Last update posted :
    11/28/2023
    Initiation :
    10/09/2018
    Primary completion :
    04/01/2024
    Completion :
    04/01/2024
    CD34
    |
    cytarabine • etoposide IV • melphalan • thiotepa
    Intensive Conditioning With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement (NCT06111612)
    Phase N/A
    Shanghai General Hospital, Shanghai Jiao Tong U...
    Not yet recruiting
    Last update posted :
    11/28/2023
    Initiation :
    01/01/2024
    Primary completion :
    01/01/2026
    Completion :
    01/01/2027
    HLA-DRB1 • HLA-B • HLA-C
    |
    cytarabine • fludarabine IV • thiotepa • busulfan
    Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best Donor (NCT02880293)
    Phase N/A
    Memorial Sloan Kettering Cancer Center
    Completed
    Last update posted :
    11/21/2023
    Initiation :
    08/23/2016
    Primary completion :
    11/20/2023
    Completion :
    11/20/2023
    TP53 • FLT3 • ABL1 • BCR • RUNX1 • ASXL1 • CRLF2 • IKZF1
    |
    TP53 mutation • FLT3 mutation • RUNX1 mutation • ASXL1 mutation • IKZF1 mutation • MLL mutation
    |
    cyclophosphamide • melphalan • fludarabine IV • mesna • thiotepa • Neupogen (filgrastim) • cyclophosphamide intravenous
    Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer (NCT04521946)
    Phase 1
    M.D. Anderson Cancer Center
    Withdrawn
    Last update posted :
    10/04/2023
    Initiation :
    01/14/2021
    Primary completion :
    12/20/2022
    Completion :
    12/20/2022
    HLA-DRB1 • HLA-B • HLA-C • KIR2DS2
    |
    etoposide IV • melphalan • fludarabine IV • thiotepa
    Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma (NCT02605421)
    Phase 2
    Masonic Cancer Center, University of Minnesota
    Recruiting
    Last update posted :
    10/03/2023
    Initiation :
    06/01/2016
    Primary completion :
    07/01/2024
    Completion :
    07/01/2025
    CD34
    |
    carboplatin • cyclophosphamide • etoposide IV • melphalan • thiotepa • cyclophosphamide intravenous
    Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma (COG-ACNS0334) (NCT00336024)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    09/25/2023
    Initiation :
    08/06/2007
    Primary completion :
    12/31/2016
    Completion :
    12/31/2028
    IGF1
    |
    cisplatin • carboplatin • cyclophosphamide • etoposide IV • methotrexate • vincristine • leucovorin calcium • thiotepa • Neupogen (filgrastim) • cyclophosphamide intravenous • methotrexate IV
    Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies (NCT01760655)
    Phase 2
    Sidney Kimmel Cancer Center at Thomas Jefferson...
    Completed
    Last update posted :
    01/06/2023
    Initiation :
    12/24/2012
    Primary completion :
    04/15/2022
    Completion :
    12/05/2022
    TP53 • FLT3
    |
    TP53 deletion • Chr del(5q) • Chr del(7q)
    |
    cyclophosphamide • fludarabine IV • thiotepa • busulfan • cyclophosphamide intravenous
    Clofarabine, Melphalan, and Thiotepa Followed By a Donor Stem Cell Transplant in Treating Patients With High-Risk and/or Advanced Hematologic Cancer or Other Disease (NCT00423514)
    Phase 1/2
    Memorial Sloan Kettering Cancer Center
    Completed
    Last update posted :
    12/26/2022
    Initiation :
    11/20/2006
    Primary completion :
    06/18/2021
    Completion :
    06/18/2021
    HLA-DRB1 • HLA-B • HLA-C
    |
    clofarabine • melphalan • thiotepa • Neupogen (filgrastim)
    Conditioning Regimen and the Transplantation of Unrelated Donor Umbilical Cord Blood in Patients With Hematologic Malignancies. (NCT00739141)
    Phase 2
    Memorial Sloan Kettering Cancer Center
    Completed
    Last update posted :
    12/08/2022
    Initiation :
    08/12/2008
    Primary completion :
    10/15/2021
    Completion :
    10/15/2021
    KMT2A
    |
    MLL rearrangement • MLL rearrangement
    |
    cyclophosphamide • fludarabine IV • thiotepa • cyclophosphamide intravenous
    Neo Adjuvant Chemotherapy in Triple Negative Breast Cancer (neo-TN) (NCT01057069)
    Phase 2/3
    The Netherlands Cancer Institute
    Active, not recruiting
    Last update posted :
    10/12/2022
    Initiation :
    01/01/2010
    Primary completion :
    06/01/2023
    Completion :
    12/01/2029
    HER-2 • ER • PGR
    |
    HER-2 negative • ER negative
    |
    carboplatin • paclitaxel • doxorubicin hydrochloride • cyclophosphamide • thiotepa
    High Dose Chemotherapy in Oligo-metastatic Homologous Recombination Deficient Breast Cancer (NCT01646034)
    Phase 3
    The Netherlands Cancer Institute
    Active, not recruiting
    Last update posted :
    10/12/2022
    Initiation :
    09/01/2014
    Primary completion :
    01/01/2023
    Completion :
    10/01/2026
    HER-2 • ER • BRCA1 • BRCA2
    |
    HER-2 negative
    |
    carboplatin • gemcitabine • paclitaxel • docetaxel • doxorubicin hydrochloride • cyclophosphamide • thiotepa
    CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies (2019-KOE-001) (NCT04282174)
    Phase 2
    Baptist Health South Florida
    Withdrawn
    Last update posted :
    09/27/2022
    Initiation :
    09/01/2022
    Primary completion :
    03/01/2030
    Completion :
    03/01/2030
    CD34
    |
    cyclophosphamide • melphalan • fludarabine IV • thiotepa • busulfan • cyclophosphamide intravenous