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    CANCER:

    Testicular Seminoma

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    Nivolumab and Ipilimumab in Treating Patients With Rare Tumors (SWOG S1609) (NCT02834013)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/06/2025
    Initiation :
    01/30/2017
    Primary completion :
    05/01/2026
    Completion :
    05/01/2026
    CD4
    |
    PD-L1 overexpression
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Yervoy (ipilimumab) • CS1002 (ipilimumab biosimilar) • ABP 206 (nivolumab biosimilar) • CMAB 819 (nivolumab biosimilar) • MK-1088
    Retroperitoneal Lymph Node Dissection in Treating Patients With Testicular Seminoma (SEMS) (NCT02537548)
    Phase N/A
    University of Southern California
    Active, not recruiting
    Last update posted :
    03/18/2024
    Initiation :
    08/28/2015
    Primary completion :
    08/28/2025
    Completion :
    08/28/2026
    AFP
    De-escalation Study for Stage IIa/IIb < 3 cm Seminoma (EDEN) (NCT05529251)
    Phase 2
    Centre Leon Berard
    Recruiting
    Last update posted :
    01/25/2024
    Initiation :
    09/06/2022
    Primary completion :
    09/06/2025
    Completion :
    09/06/2030
    AFP
    |
    carboplatin
    A Study of miRNA 371 in Patients With Germ Cell Tumors (SWOG-S1823) (NCT04435756)
    Phase N/A
    SWOG Cancer Research Network
    Recruiting
    Last update posted :
    12/12/2023
    Initiation :
    07/28/2020
    Primary completion :
    06/01/2026
    Completion :
    10/01/2026
    AFP
    Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer (SWENOTECA-ABC) (NCT02341989)
    Phase 3
    St. Olavs Hospital
    Recruiting
    Last update posted :
    07/06/2023
    Initiation :
    04/08/2015
    Primary completion :
    12/01/2035
    Completion :
    12/01/2035
    AFP
    |
    AFP elevation
    |
    cisplatin • carboplatin • etoposide IV • bleomycin
    Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer (NCT01037790)
    Phase 2
    Abramson Cancer Center of the University of Pen...
    Completed
    Last update posted :
    03/11/2021
    Initiation :
    10/01/2009
    Primary completion :
    10/01/2019
    Completion :
    10/01/2019
    HER-2 • KRAS • BRAF • ER • RB1 • CCND1 • CDK4 • CCND2
    |
    KRAS mutation • ER positive • BRAF mutation • CCND1 amplification • CDK4 amplification • RB1 positive • CDK4 mutation
    |
    cisplatin • Ibrance (palbociclib)
    Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma (Car-PET) (NCT02272816)
    Phase 2
    Barts & The London NHS Trust
    Completed
    Last update posted :
    01/25/2019
    Initiation :
    02/13/2012
    Primary completion :
    10/13/2017
    Completion :
    10/13/2017
    AFP
    |
    carboplatin
    Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors (NCT00957905)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    03/10/2017
    Initiation :
    06/01/2009
    Primary completion :
    08/01/2014
    Completion :
    08/01/2014
    AFP
    |
    AFP elevation
    |
    cisplatin • 5-fluorouracil • oxaliplatin • leucovorin calcium • alvocidib (DSP-2033) • fluorouracil topical
    Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma (SEMITEP) (NCT01887340)
    Phase 2
    Gustave Roussy, Cancer Campus, Grand Paris
    Recruiting
    Last update posted :
    06/09/2016
    Initiation :
    06/01/2013
    Primary completion :
    06/01/2016
    Completion :
    06/01/2026
    AFP
    |
    cisplatin • carboplatin • etoposide IV