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    Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia (NCT01409161)
    Phase 2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    01/28/2025
    Initiation :
    10/05/2011
    Primary completion :
    12/18/2025
    Completion :
    12/18/2025
    RARA • PML
    |
    Mylotarg (gemtuzumab ozogamicin) • Vesanoid (tretinoin) • arsenic trioxide
    THIO Sequenced with Cemiplimab in Advanced NSCLC (THIO-101) (NCT05208944)
    Phase 2
    Maia Biotechnology
    Active, not recruiting
    Last update posted :
    11/22/2024
    Initiation :
    06/08/2022
    Primary completion :
    08/31/2025
    Completion :
    10/31/2026
    IL6 • CRP
    |
    Libtayo (cemiplimab-rwlc) • THIO
    All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer (NCT04919369)
    Phase 1
    Dwight Owen
    Recruiting
    Last update posted :
    03/13/2024
    Initiation :
    10/18/2021
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    PD-L1 • ALK
    |
    Tecentriq (atezolizumab) • Vesanoid (tretinoin)
    RWE of 1st Line Treatment With ATO/ATRA for Adult APL (NCT04897490)
    Phase N/A
    Grupo Argentino de Tratamiento de la Leucemia A...
    Recruiting
    Last update posted :
    01/09/2024
    Initiation :
    03/01/2021
    Primary completion :
    07/01/2026
    Completion :
    12/01/2026
    BCR
    |
    FLT3 mutation
    |
    Vesanoid (tretinoin) • arsenic trioxide
    Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia (NCT02339740)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    11/22/2023
    Initiation :
    07/21/2015
    Primary completion :
    10/31/2020
    Completion :
    09/22/2024
    FLT3 • RARA • PML
    |
    FLT3 mutation • FLT3 wild-type
    |
    cytarabine • idarubicin hydrochloride • mitoxantrone • Vesanoid (tretinoin) • arsenic trioxide • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate)
    Evaluation of ATRA Activity in Combination With Anastrozole in Pre-operative Phase of Operable Early Breast Cancer (NCT04113863)
    Phase 2
    Mario Negri Institute for Pharmacological Research
    Recruiting
    Last update posted :
    10/19/2023
    Initiation :
    06/18/2019
    Primary completion :
    08/01/2024
    Completion :
    09/01/2024
    HER-2
    |
    HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
    |
    anastrozole • Vesanoid (tretinoin)
    Phase 2 Study of Telomelysin (OBP-301) in Combination With Pembrolizumab in Esophagogastric Adenocarcinoma (NCT03921021)
    Phase 2
    Weill Medical College of Cornell University
    Completed
    Last update posted :
    07/27/2023
    Initiation :
    05/09/2019
    Primary completion :
    06/20/2023
    Completion :
    07/20/2023
    PD-L1
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • Telomelysin (suratadenoturev)
    AST-VAC2 Vaccine in Patients With Non-small Cell Lung Cancer (CRUKD/17/003) (NCT03371485)
    Phase 1
    Cancer Research UK
    Completed
    Last update posted :
    03/22/2023
    Initiation :
    06/01/2018
    Primary completion :
    08/08/2022
    Completion :
    08/08/2022
    TERT
    |
    VAC2
    Efficacy and Safety of ATO Plus ATRA in Nucleophosmin-1 Mutated Acute Myeloid Leukemia (NCT03031249)
    Phase 1/2
    Institute of Hematology & Blood Diseases Hospital
    Recruiting
    Last update posted :
    03/20/2020
    Initiation :
    02/08/2017
    Primary completion :
    12/01/2021
    Completion :
    12/01/2022
    NPM1
    |
    NPM1 mutation
    |
    cytarabine • Vesanoid (tretinoin) • arsenic trioxide
    A Phase III Study to Assess the Efficacy and Safety of GV1001-Gem/Cap vs Gem/Cap in Pancreatic Cancer Patients (KG 4/2015) (NCT02854072)
    Phase 3
    Samsung Pharmaceutical Co., Ltd.
    Unknown status
    Last update posted :
    11/22/2016
    Initiation :
    11/01/2015
    Primary completion :
    05/01/2018
    Completion :
    05/01/2018
    CCL11 • CA 19-9
    |
    gemcitabine • capecitabine • LucaVax (tertomotide)
    ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML) (NCT01067274)
    Phase 3
    Acute Leukemia French Association
    Withdrawn
    Last update posted :
    12/30/2015
    Initiation :
    04/01/2010
    Primary completion :
    04/01/2016
    FLT3
    |
    MLL mutation
    |
    cytarabine • azacitidine • idarubicin hydrochloride • Vesanoid (tretinoin)
    A Study of GRN163L With Paclitaxel and Bevacizumab to Treat Patients With Locally Recurrent Or Metastatic Breast Cancer (NCT00732056)
    Phase 1/2
    Geron Corporation
    Completed
    Last update posted :
    12/24/2015
    Initiation :
    07/01/2008
    Primary completion :
    09/01/2011
    Completion :
    03/01/2012
    HER-2
    |
    HER-2 positive
    |
    Avastin (bevacizumab) • paclitaxel • Rytelo (imetelstat)