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DRUG CLASS:

γδ TCR modulator

Phase 1
Seagen Inc.
Recruiting
Last update posted :
02/20/2025
Initiation :
11/14/2023
Primary completion :
07/31/2027
Completion :
09/30/2028
EGFR • ALK • MSI
|
EGFR mutation • MSI-H/dMMR • ALK rearrangement
|
PF-08046052
Phase 1/2
Chinese PLA General Hospital
Recruiting
Last update posted :
02/19/2025
Initiation :
12/11/2022
Primary completion :
12/31/2026
Completion :
12/31/2027
BCL2 • CCND1 • BCL6
|
CD19 positive • Chr t(11;14)
|
cyclophosphamide • fludarabine IV • Mustargen (mechlorethamine)
Phase 1
Cullinan Therapeutics Inc.
Recruiting
Last update posted :
02/03/2025
Initiation :
10/29/2021
Primary completion :
03/01/2026
Completion :
06/01/2026
EGFR • ALK
|
Keytruda (pembrolizumab) • CLN-619
Phase 1
Acepodia Biotech, Inc.
Not yet recruiting
Last update posted :
05/15/2024
Initiation :
05/31/2024
Primary completion :
12/18/2026
Completion :
03/25/2027
IL2
|
Keytruda (pembrolizumab) • cyclophosphamide • fludarabine IV • ACE2016
Phase 2
Eureka Therapeutics Inc.
Recruiting
Last update posted :
05/06/2024
Initiation :
03/11/2022
Primary completion :
12/31/2026
Completion :
12/31/2026
GPC3
|
GPC3 expression • GPC3 positive
|
cyclophosphamide • Stivarga (regorafenib) • ECT204
Phase 1
H. Lee Moffitt Cancer Center and Research Insti...
Recruiting
Last update posted :
03/13/2024
Initiation :
02/26/2024
Primary completion :
01/13/2029
Completion :
12/13/2033
PSCA
|
cyclophosphamide • fludarabine IV
Phase 1/2
Eureka Therapeutics Inc.
Recruiting
Last update posted :
03/07/2024
Initiation :
07/19/2022
Primary completion :
01/31/2026
Completion :
01/31/2028
AFP
|
ET140203
Phase 1
Acepodia Biotech, Inc.
Recruiting
Last update posted :
02/28/2024
Initiation :
01/21/2023
Primary completion :
09/01/2025
Completion :
09/01/2027
CD20 • IFNG • IL6 • TNFA • IL2 • IL10
|
CD20 positive
|
Gazyva (obinutuzumab) • cyclophosphamide • fludarabine IV • ACE1831
Phase 1
Kiromic BioPharma Inc.
Recruiting
Last update posted :
12/15/2023
Initiation :
11/07/2023
Primary completion :
10/01/2024
Completion :
01/01/2027
EGFR • KRAS • BRAF • ALK • ROS1
Phase 1
Anhui Provincial Hospital
Recruiting
Last update posted :
10/24/2023
Initiation :
09/27/2023
Primary completion :
07/03/2025
Completion :
07/03/2026
IL6 • TNFA • IL2 • IL10
|
CD19 positive
|
cyclophosphamide • fludarabine IV
Phase 1
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Not yet recruiting
Last update posted :
10/20/2023
Initiation :
10/01/2023
Primary completion :
07/01/2026
Completion :
04/01/2028
IL6
|
CD19 positive
|
cyclophosphamide • fludarabine IV
Phase 1/2
Dushu Lake Hospital Affiliated to Soochow Unive...
Recruiting
Last update posted :
08/30/2023
Initiation :
06/01/2023
Primary completion :
12/31/2025
Completion :
12/31/2026
IL6 • CD276 • IL10
|
CD276 expression
|
QH104
Phase 1
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Recruiting
Last update posted :
02/16/2023
Initiation :
09/26/2022
Primary completion :
09/26/2023
Completion :
09/26/2025
CD276
|
CD276 expression
|
UTAA06
Phase 1
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Recruiting
Last update posted :
02/10/2023
Initiation :
12/27/2022
Primary completion :
12/27/2023
Completion :
12/27/2024
CD276
|
CD276 expression
|
UTAA06
Phase 1
Gadeta B.V.
Active, not recruiting
Last update posted :
09/08/2022
Initiation :
05/13/2021
Primary completion :
07/30/2023
Completion :
07/30/2024
IL6
|
GDT002
Phase 1
CytoMed Therapeutics Pte Ltd
Not yet recruiting
Last update posted :
03/31/2022
Initiation :
04/01/2022
Primary completion :
03/01/2023
Completion :
12/01/2023
NKG2D
|
CTM-N2D
Phase 1
First Affiliated Hospital Xi'an Jiaotong Univer...
Completed
Last update posted :
03/29/2021
Initiation :
12/06/2017
Primary completion :
04/13/2019
Completion :
12/08/2020
HLA-A • IFNG • IL6 • TNFA • AFP • IL2 • IL10 • IL4
|
HLA-A*02 • AFP expression
|
ET1402L1-ARTEMIS T cells
Phase 1
PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Recruiting
Last update posted :
03/08/2021
Initiation :
06/03/2020
Primary completion :
06/01/2022
Completion :
12/01/2022
CD7
|
CD7-UCAR-γδT cells • γδT Cell infusion • γδT Cell infusion agent
Phase 1
First Affiliated Hospital Xi'an Jiaotong Univer...
Unknown status
Last update posted :
08/08/2019
Initiation :
05/30/2019
Primary completion :
06/01/2021
Completion :
06/01/2022
HLA-A • IFNG • IL6 • TNFA • AFP • IL2 • IL10
|
HLA-A*02 • AFP expression • IL10 elevation • IL2 expression • IL6 expression
|
sorafenib • ET1402L1-ARTEMIS T cells
Phase 1
Beijing Doing Biomedical Co., Ltd.
Unknown status
Last update posted :
09/05/2017
Initiation :
10/01/2017
Primary completion :
04/01/2019
Completion :
04/01/2020
CD19
|
CD19 expression
|
Gamma delta T-cells • anti-CD19-CAR γδT