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DRUG:
Spectrila (asparaginase Escherichia coli)
i
Other names:
MC0707, MC1003, rASNase, ASNase
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Associations
News
Trials
Company:
Medac
Drug class:
Aspartate-ammonia ligase inhibitor, Amidohydrolase stimulant
Related drugs:
‹
pegaspargase (6)
calaspargase pegol-mknl (2)
PEGylated recombinant Erwinia chrysantemi-derived L-asparaginase (0)
erwinia asparaginase (0)
L-asparaginase (0)
JZP341 (0)
pegaspargase (6)
calaspargase pegol-mknl (2)
PEGylated recombinant Erwinia chrysantemi-derived L-asparaginase (0)
erwinia asparaginase (0)
L-asparaginase (0)
JZP341 (0)
›
Associations
News
Trials
Phase
Status
Apply
Phase
Status
Apply
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma (AALL0434) (NCT00408005)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
05/23/2024
Initiation :
01/22/2007
Primary completion :
09/30/2017
Completion :
03/07/2025
CD20 • CD8 • CD22 • CD34 • CD5 • CD7 • CD2 • MPO
|
CD22 expression
|
cytarabine • doxorubicin hydrochloride • cyclophosphamide • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • nelarabine • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexamethasone injection
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia (AAML1031) (NCT01371981)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
05/21/2024
Initiation :
06/20/2011
Primary completion :
03/31/2019
Completion :
09/30/2027
FLT3
|
FLT3-ITD mutation
|
sorafenib • cytarabine • bortezomib • etoposide IV • daunorubicin • mitoxantrone • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate)
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations (NCT04293562)
Phase 3
Children's Oncology Group
Children's Oncology Group
Active, not recruiting
Phase 3
Children's Oncology Group
Active, not recruiting
Last update posted :
04/22/2024
Initiation :
07/21/2020
Primary completion :
09/30/2027
Completion :
09/30/2027
FLT3
|
Xospata (gilteritinib) • etoposide IV • methotrexate • Mylotarg (gemtuzumab ozogamicin) • Vyxeos (cytarabine/daunorubicin liposomal formulation) • mitoxantrone • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • Erwinase (erwinia asparaginase) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate) • dexrazoxane
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome (NCT02521493)
Phase 3
Children's Oncology Group
Children's Oncology Group
Active, not recruiting
Phase 3
Children's Oncology Group
Active, not recruiting
Last update posted :
11/24/2023
Initiation :
12/23/2015
Primary completion :
06/30/2024
Completion :
06/30/2024
GATA1
|
cytarabine • etoposide IV • daunorubicin • mitoxantrone • mercaptopurine delayed release (DR6MP) • mercaptopurine • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • thioguanine • Erwinase (erwinia asparaginase) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate)
Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia (AALL0622) (NCT00720109)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Completed
Phase 2/3
National Cancer Institute (NCI)
Completed
Last update posted :
04/13/2020
Initiation :
07/14/2008
Primary completion :
12/31/2014
Completion :
03/31/2020
ABL1 • BCR
|
dasatinib • cytarabine • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Neupogen (filgrastim) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate)
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