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    DRUG:

    pentostatin

    i
    Company:
    Generic mfg.
    Drug class:
    Adenosine deaminase inhibitor
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    Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia (NCT01059786)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    05/01/2024
    Initiation :
    07/01/2010
    Primary completion :
    12/15/2022
    Completion :
    12/31/2025
    CD20 • CD22 • IL2RA • ITGAE • ITGAX • ISG20
    |
    CD20 positive
    |
    Rituxan (rituximab) • bendamustine • pentostatin
    Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant (NCT00571662)
    Phase 2
    University of Nebraska
    Completed
    Last update posted :
    10/24/2023
    Initiation :
    12/08/2000
    Primary completion :
    12/30/2008
    Completion :
    12/30/2008
    HLA-B
    |
    cyclosporin A microemulsion • pentostatin • Leukine (sargramostim)
    Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer (NCT00816413)
    Phase 1/2
    University of Nebraska
    Withdrawn
    Last update posted :
    08/14/2023
    Initiation :
    09/01/2008
    Primary completion :
    02/01/2010
    Completion :
    02/01/2010
    HLA-B • HLA-C
    |
    Chr del(5q) • Chr del(7q)
    |
    cyclosporin A microemulsion • pentostatin • cyclosporine • ondansetron intravenous
    Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL (NCT00074282)
    Phase 2
    Eastern Cooperative Oncology Group
    Completed
    Last update posted :
    06/29/2023
    Initiation :
    04/14/2005
    Primary completion :
    12/09/2017
    Completion :
    05/06/2018
    CD5 • CD2
    |
    Rituxan (rituximab) • cyclophosphamide • Campath (alemtuzumab) • pentostatin • cyclophosphamide intravenous
    Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant (NCT00096161)
    Phase 2
    Fred Hutchinson Cancer Center
    Completed
    Last update posted :
    01/31/2020
    Initiation :
    05/01/2003
    Primary completion :
    02/01/2015
    Completion :
    08/01/2015
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    cyclosporin A microemulsion • pentostatin
    Rituximab, Pentostatin, Cyclophosphamide, and Lenalidomide in Treating Patients With Previously Untreated B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (NCT00602836)
    Phase 2
    Mayo Clinic
    Completed
    Last update posted :
    01/27/2020
    Initiation :
    02/01/2008
    Primary completion :
    12/01/2010
    Completion :
    09/12/2017
    CD20 • CCND1 • CD5 • FCER2
    |
    Rituxan (rituximab) • lenalidomide • cyclophosphamide • pentostatin • cyclophosphamide intravenous
    SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma (NCT01362790)
    Phase 1/2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    06/06/2019
    Initiation :
    05/11/2011
    Primary completion :
    08/03/2016
    Completion :
    08/07/2017
    ALK • MSLN
    |
    EGFR mutation • MSLN expression • ALK translocation
    |
    cyclophosphamide • pentostatin • SS1(dsFv)-PE38 • cyclophosphamide intravenous
    Ofatumumab, Pentostatin, and Cyclophosphamide in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (NCT01024010)
    Phase 2
    Mayo Clinic
    Completed
    Last update posted :
    09/18/2018
    Initiation :
    03/01/2010
    Primary completion :
    05/01/2013
    Completion :
    09/28/2017
    CD20 • CCND1 • IGH • CD5 • FCER2
    |
    cyclophosphamide • Arzerra (ofatumumab) • pentostatin • cyclophosphamide intravenous
    Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney Cancer (NCT00923845)
    Phase 2
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    09/29/2017
    Initiation :
    03/01/2008
    Primary completion :
    06/01/2015
    Completion :
    06/22/2017
    CD8 • CD4 • FOXP3 • GATA3
    |
    cyclophosphamide • Torisel (temsirolimus) • sirolimus • pentostatin • cyclophosphamide intravenous
    Pentostatin, Cyclophosphamide, and Rituximab With or Without Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma (NCT00816595)
    Phase 2
    Mayo Clinic
    Completed
    Last update posted :
    06/15/2017
    Initiation :
    02/01/2009
    Primary completion :
    07/01/2013
    Completion :
    11/29/2016
    CD20 • CCND1 • CD5 • FCER2
    |
    Avastin (bevacizumab) • Rituxan (rituximab) • cyclophosphamide • pentostatin • Neulasta (pegfilgrastim) • cyclophosphamide intravenous
    Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia (NCT01681563)
    Phase 2
    Niguarda Hospital
    Completed
    Last update posted :
    12/28/2016
    Initiation :
    09/01/2011
    Primary completion :
    11/01/2015
    Completion :
    12/01/2016
    CD20 • CD79B • CD5 • FCER2
    |
    cyclophosphamide • Arzerra (ofatumumab) • pentostatin • cyclophosphamide intravenous
    Fludarabine, Cyclophosphamide, and Rituximab Versus Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-Cell Chronic Lymphocytic Leukemia Patients (NCT00254163)
    Phase 3
    US Oncology Research
    Completed
    Last update posted :
    11/03/2016
    Initiation :
    12/01/2003
    Primary completion :
    09/01/2011
    Completion :
    09/01/2011
    CD20 • CD5
    |
    Rituxan (rituximab) • cyclophosphamide • fludarabine IV • pentostatin