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    BIOMARKER:

    PDGFRA exon 18 mutation

    i
    Other names: Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
    Entrez ID:
    5156
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    Apply
    A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1] (NCT05489237)
    Phase 1
    IDRx, Inc.
    Recruiting
    Last update posted :
    04/09/2024
    Initiation :
    08/01/2022
    Primary completion :
    04/24/2026
    Completion :
    09/13/2026
    PDGFRA
    |
    KIT mutation • PDGFRA mutation • PDGFRA exon 18 mutation
    |
    sunitinib • IDRX-42
    Early Access Program (EAP) for Avapritinib in Patients With Locally Advanced Unresectable or Metastatic GIST (NCT03862885)
    Phase N/A
    Blueprint Medicines Corporation
    Approved for marketing
    Last update posted :
    07/27/2020
    PDGFRA
    |
    PDGFRA D842V • PDGFRA mutation • PDGFRA exon 18 mutation
    |
    Ayvakit (avapritinib)
    A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST (NCT02776878)
    Phase N/A
    Peking University Cancer Hospital & Institute
    Unknown status
    Last update posted :
    05/18/2016
    Initiation :
    05/01/2016
    Primary completion :
    10/01/2017
    Completion :
    05/01/2018
    KIT • PDGFRA • ANO1
    |
    KIT exon 11 mutation • PDGFRA mutation • KIT wild-type • PDGFRA exon 18 mutation • PDGFR wild-type
    |
    dasatinib