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BIOMARKER:
PDGFRA exon 18 mutation
i
Other names:
Platelet Derived Growth Factor Receptor Alpha, Platelet-Derived Growth Factor Receptor Alpha Polypeptide, Alpha-Type Platelet-Derived Growth Factor Receptor, CD140 Antigen-Like Family Member A, CD140a Antigen, PDGF-R-Alpha, PDGFR-2, PDGFR2, Alpha Platelet-Derived Growth Factor Receptor, Platelet-Derived Growth Factor Alpha Receptor, PDGFR-Alpha, RHEPDGFRA, CD140A
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Entrez ID:
5156
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Associations
(3)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
A First-in-human (FIH) Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) [Study ID: StrateGIST 1] (NCT05489237)
Phase 1
IDRx, Inc.
IDRx, Inc.
Recruiting
Phase 1
IDRx, Inc.
Recruiting
Last update posted :
04/09/2024
Initiation :
08/01/2022
Primary completion :
04/24/2026
Completion :
09/13/2026
PDGFRA
|
KIT mutation • PDGFRA mutation • PDGFRA exon 18 mutation
|
sunitinib • IDRX-42
Early Access Program (EAP) for Avapritinib in Patients With Locally Advanced Unresectable or Metastatic GIST (NCT03862885)
Phase N/A
Blueprint Medicines Corporation
Blueprint Medicines Corporation
Approved for marketing
Phase N/A
Blueprint Medicines Corporation
Approved for marketing
Last update posted :
07/27/2020
PDGFRA
|
PDGFRA D842V • PDGFRA mutation • PDGFRA exon 18 mutation
|
Ayvakit (avapritinib)
A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST (NCT02776878)
Phase N/A
Peking University Cancer Hospital & Institute
Peking University Cancer Hospital & Ins...
Unknown status
Phase N/A
Peking University Cancer Hospital & Institute
Unknown status
Last update posted :
05/18/2016
Initiation :
05/01/2016
Primary completion :
10/01/2017
Completion :
05/01/2018
KIT • PDGFRA • ANO1
|
KIT exon 11 mutation • PDGFRA mutation • KIT wild-type • PDGFRA exon 18 mutation • PDGFR wild-type
|
dasatinib
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