^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    Grafapex (treosulfan)

    i
    Company:
    Medac, Medexus
    Drug class:
    Alkylating agent
    Related drugs:
    Apply
    Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904) (NCT04965597)
    Phase 2
    Fred Hutchinson Cancer Center
    Active, not recruiting
    Last update posted :
    02/07/2025
    Initiation :
    04/19/2022
    Primary completion :
    12/01/2025
    Completion :
    12/01/2026
    HLA-DRB1 • HLA-DQB1 • GATA2 • HLA-B • HLA-C
    |
    LDH elevation
    |
    methotrexate • fludarabine IV • busulfan • Grafapex (treosulfan) • methotrexate IV
    Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia (NCT04994808)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    02/05/2025
    Initiation :
    08/11/2023
    Primary completion :
    10/03/2026
    Completion :
    04/03/2027
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    clofarabine • fludarabine IV • busulfan • Grafapex (treosulfan)
    Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies (NCT04195633)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    05/23/2024
    Initiation :
    01/25/2021
    Primary completion :
    12/31/2024
    Completion :
    12/31/2026
    HLA-DRB1
    |
    cyclophosphamide • fludarabine IV • busulfan • cyclosporin A microemulsion • Grafapex (treosulfan) • Neupogen (filgrastim) • cyclophosphamide intravenous
    Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML (NCT05807932)
    Phase 1/2
    Heinrich-Heine University, Duesseldorf
    Recruiting
    Last update posted :
    05/01/2024
    Initiation :
    06/26/2023
    Primary completion :
    01/31/2026
    Completion :
    01/30/2028
    KRAS • TP53 • NRAS • IDH1 • IDH2 • NF1 • RUNX1 • KMT2A • PTPN11 • NUP214 • DEK • RIT1
    |
    KRAS mutation • NRAS mutation • NF1 mutation • RAS mutation • CBL mutation
    |
    Venclexta (venetoclax) • cytarabine • fludarabine IV • Grafapex (treosulfan) • Amsidine (amsacrine)
    Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics (NCT05534620)
    Phase 1
    medac GmbH
    Recruiting
    Last update posted :
    02/21/2024
    Initiation :
    02/01/2024
    Primary completion :
    08/01/2025
    Completion :
    12/01/2025
    HLA-DRB1
    |
    fludarabine IV • Grafapex (treosulfan)
    Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders (NCT03980769)
    Phase 2
    Fred Hutchinson Cancer Center
    Recruiting
    Last update posted :
    02/05/2024
    Initiation :
    05/05/2021
    Primary completion :
    07/01/2027
    Completion :
    07/01/2027
    HLA-DRB1 • CD34 • HLA-DQB1 • HLA-B • HLA-C
    |
    fludarabine IV • thiotepa • busulfan • Grafapex (treosulfan)
    Dose-range Finding Treosulfan-based Conditioning (NCT01063647)
    Phase 2
    medac GmbH
    Completed
    Last update posted :
    11/03/2023
    Initiation :
    11/01/2001
    Primary completion :
    06/01/2005
    Completion :
    06/01/2006
    ABL1 • BCR • HLA-DRB1
    |
    Chr del(5q)
    |
    Grafapex (treosulfan)
    Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplant (NCT00796068)
    Phase 2
    Fred Hutchinson Cancer Center
    Completed
    Last update posted :
    02/17/2023
    Initiation :
    02/24/2009
    Primary completion :
    12/14/2021
    Completion :
    12/14/2021
    HLA-DRB1 • CD34 • HLA-B
    |
    fludarabine IV • busulfan • cyclosporin A microemulsion • Grafapex (treosulfan)
    Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders (NCT00919503)
    Phase 2
    Fred Hutchinson Cancer Center
    Completed
    Last update posted :
    08/13/2021
    Initiation :
    07/31/2009
    Primary completion :
    06/10/2020
    Completion :
    06/10/2020
    CD33 • HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    methotrexate • fludarabine IV • busulfan • cyclosporin A microemulsion • Grafapex (treosulfan) • methotrexate IV
    Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia (NCT00860574)
    Phase 2
    Fred Hutchinson Cancer Center
    Completed
    Last update posted :
    06/22/2021
    Initiation :
    02/01/2009
    Primary completion :
    02/01/2013
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    fludarabine IV • busulfan • Grafapex (treosulfan) • methotrexate IV
    Treo/Flu/TBI With Donor Stem Cell Transplant for Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia (NCT01894477)
    Phase 2
    Fred Hutchinson Cancer Center
    Active, not recruiting
    Last update posted :
    06/03/2021
    Initiation :
    11/01/2013
    Primary completion :
    01/09/2017
    Completion :
    06/01/2022
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    fludarabine IV • busulfan • Grafapex (treosulfan)
    Personalized Targeted Preparative Regimen Before T-depleted Allogeneic HSCT in Children With Chemoresistent Acute Leukemias (NCT04000698)
    Phase 3
    Federal Research Institute of Pediatric Hematol...
    Recruiting
    Last update posted :
    11/20/2020
    Initiation :
    10/15/2019
    Primary completion :
    07/01/2022
    Completion :
    12/01/2022
    BCL2 • CXCR4 • CD38
    |
    CD38 expression • BCL2 expression
    |
    Venclexta (venetoclax) • cytarabine • Actemra IV (tocilizumab) • Grafapex (treosulfan)
    Clinical Phase III Trial Treosulfan-based Conditioning Versus Reduced-intensity Conditioning (RIC) (MC-FludT.14/L) (NCT00822393)
    Phase 3
    medac GmbH
    Completed
    Last update posted :
    07/30/2020
    Initiation :
    11/24/2008
    Primary completion :
    01/25/2018
    Completion :
    01/25/2018
    HLA-DRB1
    |
    busulfan • Grafapex (treosulfan)
    Treosulfan-based Conditioning in Paediatric Patients With Haematological Malignancies (NCT02333058)
    Phase 2
    medac GmbH
    Completed
    Last update posted :
    05/04/2020
    Initiation :
    11/21/2014
    Primary completion :
    12/24/2016
    Completion :
    09/30/2019
    HLA-DRB1
    |
    fludarabine IV • Grafapex (treosulfan)
    A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC (ModuLung) (NCT02852083)
    Phase 2
    University Hospital Regensburg
    Unknown status
    Last update posted :
    01/18/2018
    Initiation :
    01/01/2016
    Primary completion :
    07/01/2019
    Completion :
    07/01/2020
    EGFR • ALK • PD-1 • RAS • PPARG • PPARA
    |
    Opdivo (nivolumab) • Grafapex (treosulfan)
    Treosulfan/Fludarabine/Low Dose TBI as a Preparative Regimen for Children With AML/MDS Undergoing Allo HCT (NCT01772953)
    Phase 2
    Center for International Blood and Marrow Trans...
    Completed
    Last update posted :
    10/12/2016
    Initiation :
    09/01/2013
    Primary completion :
    08/01/2015
    Completion :
    08/01/2015
    HLA-DRB1 • HLA-B • HLA-C
    |
    fludarabine IV • Grafapex (treosulfan)
    Treosulfan-based Conditioning for Allogeneic Stem-cell Transplantation (SCT) in Lymphoid Malignancies (NCT01079013)
    Phase 2
    Sheba Medical Center
    Unknown status
    Last update posted :
    04/20/2016
    Initiation :
    03/01/2010
    Primary completion :
    04/01/2018
    Completion :
    04/01/2018
    HLA-DRB1 • CD34 • HLA-B • HLA-C
    |
    melphalan • fludarabine IV • Grafapex (treosulfan)
    Treosulfan-based Conditioning for Transplantation in AML/MDS (NCT00491634)
    Phase 2
    Dr. Avichai Shimoni MD
    Completed
    Last update posted :
    12/02/2015
    Initiation :
    06/01/2007
    Primary completion :
    06/01/2014
    Completion :
    06/01/2014
    HLA-DRB1 • CD34 • HLA-B • HLA-C
    |
    fludarabine IV • Grafapex (treosulfan)
    Allogeneic Stem Cell Transplantation (SCT) With Treosulfan, VP-16 and Cyclophosphamid for Patients With Acute Lymphoblastic Leukemia (ALL) (NCT00682305)
    Phase 2
    Universitätsklinikum Hamburg-Eppendorf
    Completed
    Last update posted :
    05/13/2015
    Initiation :
    03/01/2007
    Primary completion :
    01/01/2013
    Completion :
    08/01/2013
    HLA-DRB1 • HLA-DQB1 • HLA-B • HLA-C
    |
    cyclophosphamide • Grafapex (treosulfan)