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    DRUG:

    Ontak (denileukin diftitox)

    i
    Company:
    Dr. Reddy’s, Eisai, TSD Japan
    Drug class:
    IL-2 stimulant
    Related drugs:
    Apply
    Study of E7777 Prior to Kymriah for R/R DLBCL (NCT04855253)
    Phase 1/2
    Masonic Cancer Center, University of Minnesota
    Recruiting
    Last update posted :
    07/07/2023
    Initiation :
    06/09/2021
    Primary completion :
    12/01/2024
    Completion :
    12/01/2024
    MYC
    |
    MYC expression
    |
    Kymriah (tisagenlecleucel-T) • Ontak (denileukin diftitox) • Lymphir (denileukin diftitox-cxdl)
    A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma (NCT01871727)
    Phase 3
    Eisai Inc.
    Completed
    Last update posted :
    12/12/2022
    Initiation :
    05/30/2013
    Primary completion :
    12/06/2021
    Completion :
    12/14/2021
    IL2RA • IL2 • ISG20
    |
    Ontak (denileukin diftitox) • Lymphir (denileukin diftitox-cxdl)
    Study of Denileukin Diftitox in Participants With Stage IIIC and Stage IV Melanoma (NCT01127451)
    Phase 2
    Eisai Inc.
    Completed
    Last update posted :
    04/13/2022
    Initiation :
    06/22/2010
    Primary completion :
    04/07/2015
    Completion :
    04/07/2015
    BRAF • CTLA4 • CD4 • IL7R • ISG20
    |
    Ontak (denileukin diftitox)
    Study of E7777 in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma and Cutaneous T-cell Lymphoma (NCT02676778)
    Phase 2
    Eisai Co., Ltd.
    Completed
    Last update posted :
    07/15/2021
    Initiation :
    03/28/2016
    Primary completion :
    04/26/2019
    Completion :
    04/26/2019
    IL2
    |
    Ontak (denileukin diftitox) • Lymphir (denileukin diftitox-cxdl)
    A Study of ONTAK and CHOP in Newly Diagnosed, Peripheral T-Cell Lymphoma (NCT00211185)
    Phase 2
    Eisai Inc.
    Completed
    Last update posted :
    03/18/2020
    Initiation :
    03/14/2004
    Primary completion :
    08/01/2008
    Completion :
    12/23/2009
    TNFRSF8
    |
    doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Ontak (denileukin diftitox) • Neulasta (pegfilgrastim) • cyclophosphamide intravenous
    Denileukin Diftitox Used in Treating Patients With Advanced Refractory Ovarian Cancer, Primary Peritoneal Carcinoma, or Epithelial Fallopian Tube Cancer (NCT00357448)
    Phase 1
    University of Washington
    Completed
    Last update posted :
    05/14/2019
    Initiation :
    04/01/2005
    Primary completion :
    11/01/2009
    IL6 • TNFA • IL2 • IL10 • TGFB1 • TGFB2
    |
    Ontak (denileukin diftitox)
    ONTAK® in Treating Patients With Advanced Breast Cancer That Did Not Respond to Previous Treatment (NCT00425672)
    Phase 1/2
    University of Washington
    Completed
    Last update posted :
    12/05/2018
    Initiation :
    09/01/2005
    Primary completion :
    04/01/2010
    IL2RA
    |
    IL2RA expression • IL2 expression
    |
    Ontak (denileukin diftitox)
    Rituximab and Denileukin Diftitox in Treating Patients With Previously Untreated Stage III or Stage IV Follicular B-Cell Non-Hodgkin's Lymphoma (NCT00460109)
    Phase 2
    Alliance for Clinical Trials in Oncology
    Completed
    Last update posted :
    04/18/2017
    Initiation :
    04/01/2008
    Primary completion :
    10/01/2010
    Completion :
    03/01/2011
    ALB
    |
    Rituxan (rituximab) • Ontak (denileukin diftitox)
    Denileukin Diftitox in Treating Patients With Fludarabine-Refractory B-Cell Chronic Lymphocytic Leukemia (NCT00082940)
    Phase 2
    Wake Forest University Health Sciences
    Completed
    Last update posted :
    01/19/2017
    Initiation :
    08/01/2002
    Primary completion :
    01/01/2005
    Completion :
    06/01/2005
    CD5
    |
    fludarabine IV • Ontak (denileukin diftitox)
    Combination Chemotherapy and Denileukin Diftitox in Treating Patients With Newly Diagnosed T-Cell Non-Hodgkin Lymphoma (NCT00513188)
    Phase N/A
    University of Miami
    Withdrawn
    Last update posted :
    12/15/2016
    Initiation :
    02/01/2007
    Primary completion :
    06/01/2008
    IL2RA • ISG20
    |
    IL2RA expression
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • leucovorin calcium • Ontak (denileukin diftitox)