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    Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations (AALL1131) (NCT02883049)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/21/2025
    Initiation :
    02/29/2012
    Primary completion :
    12/31/2022
    Completion :
    10/03/2025
    ABL1 • BCR • RUNX1 • KMT2A • ETV6
    |
    MLL rearrangement
    |
    dasatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • methotrexate • vincristine • prednisone • daunorubicin • clofarabine • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL) (NCT06124157)
    Phase 3
    National Cancer Institute (NCI)
    Not yet recruiting
    Last update posted :
    02/14/2025
    Initiation :
    05/29/2025
    Primary completion :
    12/01/2030
    Completion :
    12/01/2030
    ABL1 • KIT • PDGFRA • CD19 • PDGFRB • CSF1R
    |
    CD19 expression
    |
    dasatinib • imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • Blincyto (blinatumomab) • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Starasid (cytarabine ocfosfate)
    Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia (AALL1621) (NCT02981628)
    Phase 2
    Children's Oncology Group
    Recruiting
    Last update posted :
    02/13/2025
    Initiation :
    06/19/2017
    Primary completion :
    03/31/2026
    Completion :
    03/31/2026
    KMT2A • CD22
    |
    MLL rearrangement • CD22 expression
    |
    cytarabine • cyclophosphamide • methotrexate • Besponsa (inotuzumab ozogamicin) • vincristine • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (AALL1631) (NCT03007147)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    02/13/2025
    Initiation :
    08/08/2017
    Primary completion :
    09/30/2027
    Completion :
    09/30/2027
    ABL1 • BCR • PDGFRA • PDGFRB • IKZF1 • CSF1R
    |
    BCR-ABL1 fusion • ABL1 fusion
    |
    imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • dexamethasone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Hemady (dexamethasone tablets) • Neupogen (filgrastim) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexrazoxane • levoleucovorin calcium • prednisolone
    A Study of Revumenib in Combination With Chemotherapy for Patients Diagnosed With Relapsed or Refractory Leukemia (NCT05761171)
    Phase 2
    Children's Oncology Group
    Recruiting
    Last update posted :
    02/13/2025
    Initiation :
    01/08/2024
    Primary completion :
    12/31/2027
    Completion :
    12/31/2027
    KMT2A
    |
    MLL rearrangement
    |
    cytarabine • methotrexate • vincristine • Revuforj (revumenib) • Oncaspar liquid (pegaspargase) • fludarabine IV • Asparlas (calaspargase pegol-mknl) • Starasid (cytarabine ocfosfate)
    Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma (NCT05602194)
    Phase 3
    Children's Oncology Group
    Recruiting
    Last update posted :
    02/12/2025
    Initiation :
    08/24/2023
    Primary completion :
    06/30/2028
    Completion :
    12/30/2028
    CRLF2 • PNPLA3 • SOD2
    |
    Oncaspar liquid (pegaspargase) • Asparlas (calaspargase pegol-mknl)
    Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia (NCT03808610)
    Phase 1/2
    M.D. Anderson Cancer Center
    Active, not recruiting
    Last update posted :
    02/10/2025
    Initiation :
    04/03/2019
    Primary completion :
    12/31/2026
    Completion :
    12/31/2026
    BCL2
    |
    BCL2 expression
    |
    Venclexta (venetoclax) • Rituxan (rituximab) • cytarabine • cyclophosphamide • methotrexate • vincristine • Oncaspar liquid (pegaspargase) • Truxima (rituximab-abbs) • nelarabine • Riabni (rituximab-arrx) • Delito (rituximab biosimilar) • GB241 (rituximab biosimilar) • Novex (rituximab biosimilar) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia (ECOG-ACRIN E1910) (NCT02003222)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/06/2025
    Initiation :
    05/19/2014
    Primary completion :
    06/23/2023
    Completion :
    03/14/2025
    ABL1 • BCR • CDKN2A • RUNX1 • IGH • ETV6 • CD4 • TCF3 • PBX1
    |
    Rituxan (rituximab) • cytarabine • cyclophosphamide • etoposide IV • Blincyto (blinatumomab) • methotrexate • vincristine • prednisone • daunorubicin • dexamethasone • leucovorin calcium • Oncaspar liquid (pegaspargase) • Truxima (rituximab-abbs) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Riabni (rituximab-arrx) • Delito (rituximab biosimilar) • Hemady (dexamethasone tablets) • GB241 (rituximab biosimilar) • JHL1101 (rituximab biosimilar) • Mabtas (rituximab biosimilar) • Novex (rituximab biosimilar) • SIBP-02 (rituximab biosimilar) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma (AALL0434) (NCT00408005)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/04/2025
    Initiation :
    01/22/2007
    Primary completion :
    09/30/2017
    Completion :
    03/07/2025
    CD20 • CD8 • CD22 • CD34 • CD5 • CD7 • CD2 • MPO
    |
    CD22 expression
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • methotrexate • vincristine • daunorubicin • dexamethasone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • nelarabine • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexamethasone injection
    Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma (AALL1231) (NCT02112916)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    02/04/2025
    Initiation :
    10/04/2014
    Primary completion :
    03/31/2020
    Completion :
    09/18/2025
    CD20 • CD8 • CD22 • CD34 • CD5 • CD7 • CD2 • MPO
    |
    CD22 expression
    |
    cytarabine • bortezomib • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias (NCT05521087)
    Phase 1
    Janssen Research & Development, LLC
    Withdrawn
    Last update posted :
    02/03/2025
    Initiation :
    12/26/2025
    Primary completion :
    09/11/2026
    Completion :
    01/29/2030
    NPM1 • KMT2A • NUP98 • NUP214
    |
    cytarabine • vincristine • Oncaspar liquid (pegaspargase) • fludarabine IV • bleximenib (JNJ-6617)
    Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia (NCT06317662)
    Phase 2
    National Cancer Institute (NCI)
    Not yet recruiting
    Last update posted :
    01/29/2025
    Initiation :
    04/26/2025
    Primary completion :
    12/31/2028
    Completion :
    12/31/2028
    MCL1 • KMT2A • BCL2L1
    |
    BCL2 expression
    |
    Venclexta (venetoclax) • cytarabine • doxorubicin hydrochloride • cyclophosphamide • Blincyto (blinatumomab) • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • prednisolone
    Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia (NCT03150693)
    Phase 3
    Alliance for Clinical Trials in Oncology
    Suspended
    Last update posted :
    05/23/2024
    Initiation :
    06/01/2017
    Primary completion :
    03/01/2025
    Completion :
    08/01/2025
    ABL1 • BCR • CD20 • CD22 • ITGB1
    |
    CD20 positive • CD22 positive
    |
    Rituxan (rituximab) • cytarabine • doxorubicin hydrochloride • cyclophosphamide • Besponsa (inotuzumab ozogamicin) • vincristine • daunorubicin • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine • cyclophosphamide intravenous
    Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia (UKALL14) (NCT01085617)
    Phase 3
    University College, London
    Active, not recruiting
    Last update posted :
    05/10/2024
    Initiation :
    12/01/2010
    Primary completion :
    12/01/2024
    Completion :
    12/01/2025
    ABL1 • BCR • MYC
    |
    MYC translocation • Chr t(4;11)(q21;q23)
    |
    Rituxan (rituximab) • imatinib • cytarabine • cyclophosphamide • etoposide IV • vincristine • daunorubicin • melphalan • Oncaspar liquid (pegaspargase) • fludarabine IV • nelarabine • mercaptopurine • Kepivance (palifermin)
    A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) (AALL1821) (NCT04546399)
    Phase 2
    National Cancer Institute (NCI)
    Suspended
    Last update posted :
    04/18/2024
    Initiation :
    12/04/2020
    Primary completion :
    06/30/2028
    Completion :
    06/30/2028
    CD19
    |
    CD19 expression
    |
    Opdivo (nivolumab) • cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • Blincyto (blinatumomab) • methotrexate • vincristine • dexamethasone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexamethasone injection
    Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia (AALL0433) (NCT00381680)
    Phase 3
    Children's Oncology Group
    Completed
    Last update posted :
    03/26/2024
    Initiation :
    03/01/2007
    Primary completion :
    03/01/2016
    MYC
    |
    MYC translocation
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • prednisone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Kidrolase (L-asparaginase) • Neupogen (filgrastim) • cyclophosphamide intravenous
    Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement (AALL15P1) (NCT02828358)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    03/25/2024
    Initiation :
    04/01/2017
    Primary completion :
    09/30/2020
    Completion :
    09/22/2024
    KMT2A
    |
    KMT2A rearrangement • MLL rearrangement
    |
    cytarabine • azacitidine • cyclophosphamide • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous
    Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma (NCT03117751)
    Phase 2/3
    St. Jude Children's Research Hospital
    Active, not recruiting
    Last update posted :
    03/05/2024
    Initiation :
    03/29/2017
    Primary completion :
    09/30/2026
    Completion :
    03/31/2028
    BCL2 • CEP72
    |
    dasatinib • cytarabine • bortezomib • doxorubicin hydrochloride • Jakafi (ruxolitinib) • cyclophosphamide • etoposide IV • Blincyto (blinatumomab) • methotrexate • vincristine • prednisone • daunorubicin • Zolinza (vorinostat) • clofarabine • idarubicin hydrochloride • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • nelarabine • Asparlas (calaspargase pegol-mknl) • Rylaze (asparaginase erwinia chrysanthemi (recombinant)-rywn) • thioguanine • Erwinase (erwinia asparaginase) • Purixan (mercaptopurine oral suspension) • cyclophosphamide intravenous • prednisolone
    Tislelizumab Combined Treatment in Refractory Extranodal NK/T-cell Lymphoma (NCT05058755)
    Phase N/A
    Xinhua Hospital, Shanghai Jiao Tong University ...
    Completed
    Last update posted :
    03/04/2024
    Initiation :
    09/17/2021
    Primary completion :
    12/30/2022
    Completion :
    12/30/2023
    PD-L1
    |
    lenalidomide • Tevimbra (tislelizumab-jsgr) • azacitidine • etoposide IV • Oncaspar liquid (pegaspargase)
    A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia (AALL1521) (NCT02723994)
    Phase 2
    Incyte Corporation
    Active, not recruiting
    Last update posted :
    01/12/2024
    Initiation :
    09/30/2016
    Primary completion :
    02/01/2026
    Completion :
    02/01/2026
    JAK2 • CRLF2 • JAK1 • IL7R • EPOR • SH2B3
    |
    CRLF2 rearrangement • JAK2 mutation • IL7R mutation • JAK2 fusion • SH2B3 deletion
    |
    cytarabine • doxorubicin hydrochloride • Jakafi (ruxolitinib) • cyclophosphamide • vincristine • prednisone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine • Erwinase (erwinia asparaginase)
    Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia (NCT03571321)
    Phase 1
    University of Chicago
    Recruiting
    Last update posted :
    11/29/2023
    Initiation :
    05/28/2019
    Primary completion :
    09/01/2026
    Completion :
    09/05/2027
    JAK2 • CRLF2 • IL7R • SH2B3
    |
    CRLF2 rearrangement • JAK2 mutation • IL7R mutation • JAK2 rearrangement • SH2B3 deletion
    |
    Rituxan (rituximab) • cytarabine • doxorubicin hydrochloride • Jakafi (ruxolitinib) • cyclophosphamide • vincristine • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine • cyclophosphamide intravenous
    Phase I Study of Inotuzumab With Augmented BFM Re-Induction for Patients With Relapsed/Refractory B-cell ALL (ALL 001) (NCT03962465)
    Phase 1
    University of Virginia
    Active, not recruiting
    Last update posted :
    08/22/2023
    Initiation :
    07/22/2022
    Primary completion :
    07/15/2023
    Completion :
    07/01/2026
    CD22
    |
    CD22 positive
    |
    cytarabine • methotrexate • Besponsa (inotuzumab ozogamicin) • vincristine • prednisone • daunorubicin • Oncaspar liquid (pegaspargase)
    Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia (NCT00005585)
    Phase 3
    Children's Oncology Group
    Completed
    Last update posted :
    04/06/2023
    Initiation :
    04/01/2000
    Primary completion :
    07/01/2007
    KMT2A
    |
    MLL rearrangement • MLL rearrangement
    |
    cytarabine • cyclophosphamide • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine • Kidrolase (L-asparaginase)
    Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia (NCT05660473)
    Phase 2
    Institute of Hematology & Blood Diseases Hospital
    Recruiting
    Last update posted :
    03/03/2023
    Initiation :
    10/31/2022
    Primary completion :
    12/15/2024
    Completion :
    12/30/2027
    ABL1 • BCR
    |
    Venclexta (venetoclax) • cytarabine • cyclophosphamide • vincristine • prednisone • daunorubicin • dexamethasone • Oncaspar liquid (pegaspargase) • mercaptopurine
    Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma (NCT01700946)
    Phase 2
    St. Jude Children's Research Hospital
    Completed
    Last update posted :
    09/28/2022
    Initiation :
    04/15/2013
    Primary completion :
    07/24/2021
    Completion :
    07/24/2021
    CD20
    |
    CD20 expression
    |
    Rituxan (rituximab) • cytarabine • cyclophosphamide • etoposide IV • methotrexate • vincristine • clofarabine • mitoxantrone • Oncaspar liquid (pegaspargase) • Vumon (teniposide) • mercaptopurine • vinblastine • Proleukin (aldesleukin) • cyclophosphamide intravenous
    Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) (NCT03792256)
    Phase 1
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    03/02/2022
    Initiation :
    04/11/2019
    Primary completion :
    06/30/2021
    Completion :
    06/30/2025
    RB1 • CD8 • CDK4 • CDK6 • CD4 • CCND3
    |
    RB1 expression • CDK6 expression • CDKN1B expression
    |
    Ibrance (palbociclib) • cytarabine • doxorubicin hydrochloride • vincristine • prednisone • Oncaspar liquid (pegaspargase) • prednisolone
    Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia (CALGB 10403) (NCT00558519)
    Phase 2
    Alliance for Clinical Trials in Oncology
    Active, not recruiting
    Last update posted :
    08/18/2021
    Initiation :
    03/12/2008
    Primary completion :
    09/01/2016
    ABL1 • BCR
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • vincristine • daunorubicin • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine
    A Prospective Clinical Study of Ruxolitinib and Etoposide Combined With DDGP Regimen (RUE-DDGP) in Induction Therapy of T/NK Cell Lymphoma-associated Hemophagocytic Syndrome. (NCT04999878)
    Phase 4
    Zhengzhou University
    Recruiting
    Last update posted :
    08/11/2021
    Initiation :
    05/30/2021
    Primary completion :
    06/30/2023
    Completion :
    06/30/2024
    IL2 • CD27 • XIAP • PRF1 • UNC13D • ISG20 • RAB27A • STXBP2
    |
    gemcitabine • Jakafi (ruxolitinib) • etoposide IV • dexamethasone • Oncaspar liquid (pegaspargase)
    Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia (AALL0622) (NCT00720109)
    Phase 2/3
    National Cancer Institute (NCI)
    Completed
    Last update posted :
    04/13/2020
    Initiation :
    07/14/2008
    Primary completion :
    12/31/2014
    Completion :
    03/31/2020
    ABL1 • BCR
    |
    dasatinib • cytarabine • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Neupogen (filgrastim) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate)
    Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia (Interfant06) (NCT00550992)
    Phase N/A
    Dutch Childhood Oncology Group
    Unknown status
    Last update posted :
    07/30/2019
    Initiation :
    01/01/2006
    Primary completion :
    12/01/2020
    KMT2A • CD34
    |
    MLL rearrangement • MLL rearrangement • CD34 positive
    |
    cytarabine • cyclophosphamide • etoposide IV • vincristine • prednisone • daunorubicin • mitoxantrone • leucovorin calcium • melphalan • Oncaspar liquid (pegaspargase) • mercaptopurine • busulfan • thioguanine • cyclosporine • prednisolone
    Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (AALL1131) (NCT01406756)
    Phase 3
    Children's Oncology Group
    Recruiting
    Last update posted :
    12/13/2017
    Initiation :
    02/01/2012
    Primary completion :
    08/01/2021
    ABL1 • BCR • RUNX1 • KMT2A • ETV6
    |
    MLL rearrangement • MLL rearrangement
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • methotrexate • vincristine • prednisone • dexamethasone • clofarabine • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • thioguanine • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexamethasone injection • methylprednisolone sodium succinate
    Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL) (NCT00098839)
    Phase 2
    Children's Oncology Group
    Completed
    Last update posted :
    12/12/2017
    Initiation :
    02/01/2005
    Primary completion :
    04/01/2011
    Completion :
    04/01/2011
    CD22
    |
    CD22 expression
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • prednisone • leucovorin calcium • Oncaspar liquid (pegaspargase) • Marqibo (vincristine liposomal) • Epratucyn (epratuzumab) • Neupogen (filgrastim) • cyclophosphamide intravenous • dexrazoxane
    Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes (AALL02P2) (NCT00096135)
    Phase N/A
    Children's Oncology Group
    Completed
    Last update posted :
    03/21/2017
    Initiation :
    11/01/2004
    Primary completion :
    09/01/2013
    CD7
    |
    cytarabine • cyclophosphamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Neupogen (filgrastim) • cyclophosphamide intravenous