[{"id":"18460073-b219-4680-b839-36cecdb58964","acronym":"CALGB-40601","url":"https://clinicaltrials.gov/study/NCT00770809","created_at":"2021-01-17T17:29:01.763Z","updated_at":"2025-02-25T16:36:00.390Z","phase":"Phase 3","brief_title":"Paclitaxel and Trastuzumab With or Without Lapatinib in Treating Patients With Stage II or Stage III Breast Cancer That Can Be Removed by Surgery","source_id_and_acronym":"NCT00770809 - CALGB-40601","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • ER • PGR","pipe":" | ","alterations":" HER-2 positive • HER-2 amplification","tags":["HER-2 • ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 amplification"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • lapatinib • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 305","initiation":"Initiation: 12/01/2008","start_date":" 12/01/2008","primary_txt":" Primary completion: 01/31/2014","primary_completion_date":" 01/31/2014","study_txt":" Completion: 07/10/2025","study_completion_date":" 07/10/2025","last_update_posted":"2025-02-06"},{"id":"b1b80856-36d7-4b3b-b80b-159943ef72f4","acronym":"","url":"https://clinicaltrials.gov/study/NCT04329065","created_at":"2021-01-18T20:58:01.125Z","updated_at":"2025-02-25T16:44:52.494Z","phase":"Phase 2","brief_title":"Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy Before Surgery for the Treatment of Patients With Breast Cancer","source_id_and_acronym":"NCT04329065","lead_sponsor":"University of Washington","biomarkers":" HER-2 • ER • PGR • CD4","pipe":" | ","alterations":" ER negative • PGR negative","tags":["HER-2 • ER • PGR • CD4"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER negative • PGR negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • Perjeta (pertuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • EG1206A (pertuzumab biosimilar) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Recruiting","enrollment":" Enrollment 16","initiation":"Initiation: 04/20/2022","start_date":" 04/20/2022","primary_txt":" Primary completion: 06/30/2025","primary_completion_date":" 06/30/2025","study_txt":" Completion: 06/30/2027","study_completion_date":" 06/30/2027","last_update_posted":"2025-02-06"},{"id":"c044dc83-7f98-4b8c-81bf-f2a99c8a914c","acronym":"","url":"https://clinicaltrials.gov/study/NCT00769379","created_at":"2021-01-18T02:54:21.132Z","updated_at":"2025-02-25T16:35:59.903Z","phase":"Phase 3","brief_title":"Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy","source_id_and_acronym":"NCT00769379","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • PGR","pipe":" | ","alterations":" HER-2 positive • HR positive","tags":["HER-2 • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HR positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 2014","initiation":"Initiation: 11/10/2008","start_date":" 11/10/2008","primary_txt":" Primary completion: 12/31/2019","primary_completion_date":" 12/31/2019","study_txt":" Completion: 03/07/2025","study_completion_date":" 03/07/2025","last_update_posted":"2025-02-06"},{"id":"257cca5a-c910-4b83-b699-e799dee41eab","acronym":"","url":"https://clinicaltrials.gov/study/NCT03101748","created_at":"2021-01-18T15:16:53.226Z","updated_at":"2025-02-25T13:52:17.471Z","phase":"Phase 1/2","brief_title":"Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer","source_id_and_acronym":"NCT03101748","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 positive • HER-2 negative • HER-2 negative + HR negative","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 negative • HER-2 negative + HR negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • Nerlynx (neratinib) • Perjeta (pertuzumab) • doxorubicin hydrochloride • cyclophosphamide • Herzuma (trastuzumab-pkrb) • daunorubicin • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab) • SIBP-01 (trastuzumab biosimilar) • cyclophosphamide intravenous"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 43","initiation":"Initiation: 01/29/2018","start_date":" 01/29/2018","primary_txt":" Primary completion: 01/01/2026","primary_completion_date":" 01/01/2026","study_txt":" Completion: 01/01/2026","study_completion_date":" 01/01/2026","last_update_posted":"2024-12-13"},{"id":"0548374d-6bbb-45ae-b3fa-1857817c4f14","acronym":"MARGOT","url":"https://clinicaltrials.gov/study/NCT04425018","created_at":"2021-01-18T21:19:01.180Z","updated_at":"2025-02-25T12:27:36.881Z","phase":"Phase 2","brief_title":"MARGetuximab Or Trastuzumab (MARGOT)","source_id_and_acronym":"NCT04425018 - MARGOT","lead_sponsor":"Dana-Farber Cancer Institute","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 positive","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • Perjeta (pertuzumab) • Herzuma (trastuzumab-pkrb) • Margenza (margetuximab-cmkb) • Ogivri (trastuzumab-dkst)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 174","initiation":"Initiation: 07/13/2020","start_date":" 07/13/2020","primary_txt":" Primary completion: 09/05/2024","primary_completion_date":" 09/05/2024","study_txt":" Completion: 07/01/2027","study_completion_date":" 07/01/2027","last_update_posted":"2024-10-02"},{"id":"efccfeae-b1d6-4b39-873a-d9182d5a3bf3","acronym":"NRG-BR004","url":"https://clinicaltrials.gov/study/NCT03199885","created_at":"2021-01-18T15:46:49.625Z","updated_at":"2025-02-25T12:26:43.973Z","phase":"Phase 3","brief_title":"Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer","source_id_and_acronym":"NCT03199885 - NRG-BR004","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" ER • PGR • IL2","pipe":" | ","alterations":" HER-2 positive","tags":["ER • PGR • IL2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • Tecentriq (atezolizumab) • paclitaxel • docetaxel • Perjeta (pertuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • Paletan (pertuzumab biosimilar) • EG1206A (pertuzumab biosimilar) • GB221 (coprelotamab) • HS627 (pertuzumab biosimilar) • Pertuvia (pertuzumab biosimilar) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 190","initiation":"Initiation: 04/05/2019","start_date":" 04/05/2019","primary_txt":" Primary completion: 04/30/2024","primary_completion_date":" 04/30/2024","study_txt":" Completion: 05/15/2025","study_completion_date":" 05/15/2025","last_update_posted":"2024-09-26"},{"id":"130d64cc-8174-4099-9fdc-c77e00468d6c","acronym":"","url":"https://clinicaltrials.gov/study/NCT02003209","created_at":"2021-01-18T09:08:50.149Z","updated_at":"2024-07-02T16:35:02.395Z","phase":"Phase 3","brief_title":"Docetaxel, Carboplatin, Trastuzumab, and Pertuzumab With or Without Estrogen Deprivation in Treating Patients With Hormone Receptor-Positive, HER2-Positive Operable or Locally Advanced Breast Cancer","source_id_and_acronym":"NCT02003209","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • ER","pipe":" | ","alterations":" TILs","tags":["HER-2 • ER"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TILs"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • goserelin acetate • Herwenda (trastuzumab biosimilar) • Paletan (pertuzumab biosimilar) • EG1206A (pertuzumab biosimilar) • GB221 (coprelotamab) • HS627 (pertuzumab biosimilar) • Pertuvia (pertuzumab biosimilar) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 315","initiation":"Initiation: 01/15/2014","start_date":" 01/15/2014","primary_txt":" Primary completion: 10/31/2016","primary_completion_date":" 10/31/2016","study_txt":" Completion: 12/31/2024","study_completion_date":" 12/31/2024","last_update_posted":"2024-05-21"},{"id":"c5f41829-50ce-4b6e-882c-2736b1a86fe9","acronym":"","url":"https://clinicaltrials.gov/study/NCT01275677","created_at":"2021-01-18T05:10:25.363Z","updated_at":"2024-07-02T16:35:02.423Z","phase":"Phase 3","brief_title":"Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer","source_id_and_acronym":"NCT01275677","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • ER • PGR","pipe":" | ","alterations":" ER positive • HR positive","tags":["HER-2 • ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER positive • HR positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • docetaxel • doxorubicin hydrochloride • cyclophosphamide • Herzuma (trastuzumab-pkrb) • daunorubicin • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab) • SIBP-01 (trastuzumab biosimilar) • cyclophosphamide intravenous"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 3270","initiation":"Initiation: 01/06/2011","start_date":" 01/06/2011","primary_txt":" Primary completion: 07/31/2017","primary_completion_date":" 07/31/2017","study_txt":" Completion: 07/12/2024","study_completion_date":" 07/12/2024","last_update_posted":"2024-05-21"},{"id":"77303f62-6e39-4d65-a62b-36ab4c8e233e","acronym":"","url":"https://clinicaltrials.gov/study/NCT04266249","created_at":"2021-01-18T20:43:47.844Z","updated_at":"2025-02-25T13:53:10.003Z","phase":"Phase 2","brief_title":"CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy","source_id_and_acronym":"NCT04266249","lead_sponsor":"ECOG-ACRIN Cancer Research Group","biomarkers":" ER • PGR","pipe":" | ","alterations":" HER-2 positive • HER-2 negative","tags":["ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • docetaxel • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • albumin-bound paclitaxel • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar)"],"overall_status":"Recruiting","enrollment":" Enrollment 2156","initiation":"Initiation: 03/13/2020","start_date":" 03/13/2020","primary_txt":" Primary completion: 10/31/2026","primary_completion_date":" 10/31/2026","study_txt":" Completion: 12/31/2038","study_completion_date":" 12/31/2038","last_update_posted":"2024-04-18"},{"id":"d62c1b12-231e-41f3-9f47-89579c4ab1f5","acronym":"ACCRU-BR-1701","url":"https://clinicaltrials.gov/study/NCT04197687","created_at":"2021-01-18T20:27:24.447Z","updated_at":"2025-02-25T13:53:04.701Z","phase":"Phase 2","brief_title":"TPIV100 and Sargramostim for the Treatment of HER2 Positive, Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery","source_id_and_acronym":"NCT04197687 - ACCRU-BR-1701","lead_sponsor":"Academic and Community Cancer Research United","biomarkers":" HER-2 • ER • PGR","pipe":" | ","alterations":" HER-2 positive","tags":["HER-2 • ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • HER-2/neu peptide vaccine • Leukine (sargramostim) • TPIV100"],"overall_status":"Recruiting","enrollment":" Enrollment 480","initiation":"Initiation: 02/20/2020","start_date":" 02/20/2020","primary_txt":" Primary completion: 01/15/2025","primary_completion_date":" 01/15/2025","study_txt":" Completion: 01/15/2025","study_completion_date":" 01/15/2025","last_update_posted":"2023-12-18"},{"id":"6cdd3cff-a8f2-4076-b8fb-2e4bb4de86c2","acronym":"","url":"https://clinicaltrials.gov/study/NCT04120246","created_at":"2021-01-18T20:08:08.496Z","updated_at":"2024-07-02T16:35:26.492Z","phase":"Phase 1","brief_title":"Alpha-TEA and Trastuzumab for the Treatment of Refractory HER2+ Metastatic Breast Cancer","source_id_and_acronym":"NCT04120246","lead_sponsor":"Veana Therapeutics","biomarkers":" HER-2 • PGR","pipe":" | ","alterations":" HER-2 positive • HER-2 overexpression • PGR positive","tags":["HER-2 • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 overexpression • PGR positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • GB221 (coprelotamab) • Vimo (alpha-tocopheroloxyacetic acid)"],"overall_status":"Recruiting","enrollment":" Enrollment 24","initiation":"Initiation: 04/08/2020","start_date":" 04/08/2020","primary_txt":" Primary completion: 02/01/2024","primary_completion_date":" 02/01/2024","study_txt":" Completion: 02/01/2025","study_completion_date":" 02/01/2025","last_update_posted":"2023-12-12"},{"id":"1c68e673-30b8-48a7-84c9-a395e96c56ba","acronym":"","url":"https://clinicaltrials.gov/study/NCT02654119","created_at":"2021-01-18T12:56:02.584Z","updated_at":"2024-07-02T16:35:33.848Z","phase":"Phase 2","brief_title":"Cyclophosphamide, Paclitaxel, and Trastuzumab in Treating Stage I-II HER2/Neu Positive Breast Cancer After Surgery","source_id_and_acronym":"NCT02654119","lead_sponsor":"University of Nebraska","biomarkers":" HER-2","pipe":"","alterations":" ","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • cyclophosphamide • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • cyclophosphamide intravenous"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 20","initiation":"Initiation: 12/11/2015","start_date":" 12/11/2015","primary_txt":" Primary completion: 11/20/2025","primary_completion_date":" 11/20/2025","study_txt":" Completion: 11/20/2026","study_completion_date":" 11/20/2026","last_update_posted":"2023-10-12"},{"id":"ed55063d-4590-4057-8572-071b21a2877f","acronym":"LB1802","url":"https://clinicaltrials.gov/study/NCT03892655","created_at":"2021-01-18T19:10:30.838Z","updated_at":"2024-07-02T16:35:33.840Z","phase":"","brief_title":"Real World Study of Biosimilar Trastuzumab in Her2 Positive Breast Cancer","source_id_and_acronym":"NCT03892655 - LB1802","lead_sponsor":"Libbs Farmacêutica LTDA","biomarkers":" HER-2","pipe":" | ","alterations":" EGFR positive","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR positive"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ogivri (trastuzumab-dkst)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 170","initiation":"Initiation: 10/07/2019","start_date":" 10/07/2019","primary_txt":" Primary completion: 12/30/2022","primary_completion_date":" 12/30/2022","study_txt":" Completion: 07/01/2028","study_completion_date":" 07/01/2028","last_update_posted":"2023-10-12"},{"id":"50582c14-86ea-44cb-8fc7-88d457745d55","acronym":"","url":"https://clinicaltrials.gov/study/NCT01196390","created_at":"2021-01-17T17:23:25.790Z","updated_at":"2024-07-02T16:35:37.856Z","phase":"Phase 3","brief_title":"Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer","source_id_and_acronym":"NCT01196390","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 positive • HER-2 expression","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • carboplatin • paclitaxel • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Completed","enrollment":" Enrollment 203","initiation":"Initiation: 02/14/2011","start_date":" 02/14/2011","primary_txt":" Primary completion: 12/23/2019","primary_completion_date":" 12/23/2019","study_txt":" Completion: 08/15/2023","study_completion_date":" 08/15/2023","last_update_posted":"2023-09-07"},{"id":"4d335082-1c66-4110-a2e3-5201406c4ab1","acronym":"RTOG 0524","url":"https://clinicaltrials.gov/study/NCT00238420","created_at":"2021-01-18T00:48:23.809Z","updated_at":"2024-07-02T16:36:07.205Z","phase":"Phase 1/2","brief_title":"Paclitaxel and Radiation Therapy With or Without Trastuzumab in Treating Patients Who Have Undergone Surgery for Bladder Cancer","source_id_and_acronym":"NCT00238420 - RTOG 0524","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2","pipe":"","alterations":" ","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • GB221 (coprelotamab) • SIBP-01 (trastuzumab biosimilar)"],"overall_status":"Completed","enrollment":" Enrollment 70","initiation":"Initiation: 07/26/2005","start_date":" 07/26/2005","primary_txt":" Primary completion: 02/05/2014","primary_completion_date":" 02/05/2014","study_txt":" Completion: 05/20/2022","study_completion_date":" 05/20/2022","last_update_posted":"2022-07-19"},{"id":"6a1470b4-aafe-42be-ae24-03634efb1086","acronym":"HERiTAge","url":"https://clinicaltrials.gov/study/NCT02472964","created_at":"2021-01-18T11:54:15.262Z","updated_at":"2024-07-02T16:36:17.184Z","phase":"Phase 3","brief_title":"Study of Efficacy and Safety of Myl1401O + Taxane vs Herceptin©+ Taxane for 1st Line, Met. Br. Ca.","source_id_and_acronym":"NCT02472964 - HERiTAge","lead_sponsor":"Mylan Inc.","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 overexpression • HER-2 amplification","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 overexpression • HER-2 amplification"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e paclitaxel • docetaxel • Ogivri (trastuzumab-dkst)"],"overall_status":"Completed","enrollment":" Enrollment 500","initiation":"Initiation: 07/01/2012","start_date":" 07/01/2012","primary_txt":" Primary completion: 03/01/2016","primary_completion_date":" 03/01/2016","study_txt":" Completion: 08/01/2018","study_completion_date":" 08/01/2018","last_update_posted":"2022-02-14"},{"id":"8ec88316-aa95-4d1e-b522-4e36e6eaddba","acronym":"PerELISA","url":"https://clinicaltrials.gov/study/NCT02152943","created_at":"2021-01-17T17:27:27.104Z","updated_at":"2024-07-02T16:36:37.123Z","phase":"Phase 1","brief_title":"Everolimus, Letrozole and Trastuzumab in HR- and HER2/Neu-positive Patients","source_id_and_acronym":"NCT02152943 - PerELISA","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" ER • PGR","pipe":" | ","alterations":" ER positive • HER-2 amplification • HER-2 mutation","tags":["ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e ER positive • HER-2 amplification • HER-2 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • everolimus • letrozole • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp)"],"overall_status":"Completed","enrollment":" Enrollment 37","initiation":"Initiation: 07/17/2014","start_date":" 07/17/2014","primary_txt":" Primary completion: 12/14/2020","primary_completion_date":" 12/14/2020","study_txt":" Completion: 12/14/2020","study_completion_date":" 12/14/2020","last_update_posted":"2020-12-19"},{"id":"f4baabac-d56f-4847-a2f1-e72207388988","acronym":"N9831","url":"https://clinicaltrials.gov/study/NCT00005970","created_at":"2021-01-17T17:36:45.113Z","updated_at":"2024-07-02T16:36:41.970Z","phase":"Phase 3","brief_title":"Doxorubicin Hydrochloride, Cyclophosphamide, and Pacltaxel With or Without Trastuzumab in Treating Women With HER2-Positive Node-Positive or High-Risk Node-Negative Breast Cancer","source_id_and_acronym":"NCT00005970 - N9831","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2 • ER • PGR","pipe":" | ","alterations":" HER-2 positive • ER negative • PGR negative","tags":["HER-2 • ER • PGR"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • ER negative • PGR negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • paclitaxel • doxorubicin hydrochloride • cyclophosphamide • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar) • Soltamox (tamoxifen citrate) • cyclophosphamide intravenous"],"overall_status":"Completed","enrollment":" Enrollment 3436","initiation":"Initiation: 05/19/2000","start_date":" 05/19/2000","primary_txt":" Primary completion: 04/25/2005","primary_completion_date":" 04/25/2005","study_txt":" Completion: 01/27/2010","study_completion_date":" 01/27/2010","last_update_posted":"2020-08-14"},{"id":"d12ef9af-ee13-448c-b9f6-2f864e7e9265","acronym":"","url":"https://clinicaltrials.gov/study/NCT00006089","created_at":"2021-01-17T23:52:36.409Z","updated_at":"2024-07-02T16:36:57.501Z","phase":"Phase 2","brief_title":"Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer","source_id_and_acronym":"NCT00006089","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 amplification","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 amplification"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • Herzuma (trastuzumab-pkrb) • Ontruzant (trastuzumab-dttb) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp) • Herwenda (trastuzumab biosimilar)"],"overall_status":"Completed","enrollment":" Enrollment 34","initiation":"Initiation: 09/18/2000","start_date":" 09/18/2000","primary_txt":" Primary completion: 09/04/2007","primary_completion_date":" 09/04/2007","study_txt":" Completion: 01/31/2010","study_completion_date":" 01/31/2010","last_update_posted":"2019-07-31"},{"id":"aa2fe266-165a-4ab3-a222-bfe0fccb2cae","acronym":"","url":"https://clinicaltrials.gov/study/NCT01434303","created_at":"2021-01-18T05:55:46.269Z","updated_at":"2024-07-02T16:36:59.460Z","phase":"Phase 1","brief_title":"Entinostat, Lapatinib Ditosylate and Trastuzumab in Treating Patients With Locally Recurrent or Distant Relapsed Metastatic Breast Cancer Previously Treated With Trastuzumab Only","source_id_and_acronym":"NCT01434303","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" HER-2","pipe":" | ","alterations":" HER-2 positive • HER-2 expression","tags":["HER-2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e HER-2 positive • HER-2 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Herceptin (trastuzumab) • lapatinib • Jingzhuda (entinostat) • Ogivri (trastuzumab-dkst) • Trazimera (trastuzumab-qyyp)"],"overall_status":"Completed","enrollment":" Enrollment 37","initiation":"Initiation: 01/10/2012","start_date":" 01/10/2012","primary_txt":" Primary completion: 02/16/2016","primary_completion_date":" 02/16/2016","study_txt":" Completion: 02/16/2016","study_completion_date":" 02/16/2016","last_update_posted":"2019-05-20"}]