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    BIOMARKER:

    NOTCH1 mutation

    i
    Other names: NOTCH1, TAN1
    Entrez ID:
    4851
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    Apply
    Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (NCT03204188)
    Phase 2
    National Heart, Lung, and Blood Institute (NHLBI)
    Active, not recruiting
    Last update posted :
    11/28/2023
    Initiation :
    09/22/2017
    Primary completion :
    07/18/2022
    Completion :
    12/31/2026
    TP53 • SF3B1
    |
    TP53 mutation • NOTCH1 mutation • SF3B1 mutation
    |
    Keytruda (pembrolizumab) • Imbruvica (ibrutinib) • fludarabine IV
    ZR-CHOP in DLBCL With Specific Gene Abnormality (NCT05290337)
    Phase 2
    Fudan University
    Recruiting
    Last update posted :
    03/22/2022
    Initiation :
    01/04/2022
    Primary completion :
    01/04/2024
    Completion :
    01/04/2026
    TP53 • MYC • MYD88 • CD79B
    |
    TP53 mutation • NOTCH1 mutation • MYD88 mutation • CD79B mutation • CD79B mutation • MYC translocation
    |
    Rituxan (rituximab) • Brukinsa (zanubrutinib)
    DNA Analysis of Tissue From Patients With T-Cell Acute Lymphoblastic Leukemia (NCT00899366)
    Phase N/A
    ECOG-ACRIN Cancer Research Group
    Completed
    Last update posted :
    02/05/2020
    Initiation :
    12/28/2006
    Primary completion :
    07/30/2009
    Completion :
    07/30/2009
    NOTCH1
    |
    NOTCH1 mutation