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DRUG:
Nerofe (84AA-API 14AA)
i
Other names:
84AA-API 14AA, Tumor-Cells Apoptosis Factor, TCApF, dTCApFs
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Associations
News
Trials
Company:
Immune System Key
Drug class:
Apoptosis stimulant, Angiogenesis inhibitor, ST2 inhibitor
Related drugs:
‹
lurbinectedin (11)
arsenic trioxide (6)
STA-4783 (5)
pelareorep (4)
omacetaxine mepesuccinate (4)
GZ17-6.02 (3)
quaratusugene ozeplasmid (3)
BAL101553 (3)
teserpaturev (1)
IT-141 (1)
Alpha1H (1)
NEO100 (1)
ABI-1968 topical cream (0)
APTO-253 (0)
BP-C1 (0)
BXQ-350 (0)
CM-728 (0)
IL-17E (0)
autologous γδ T lymphocytes (0)
KLTi (0)
MT-3724 (0)
PVT-1 (0)
SVV-001 (0)
alpha-tocopheroloxyacetic acid (0)
darinaparsin (0)
AFP-464 (0)
elemene injection (0)
BAY1862864 (0)
BS-HH-002.SA (0)
PT-112 (0)
K-333 (0)
piceatannol (0)
AP1903 (0)
PRX302 (0)
SJ-C1044 (2)
VB-111 (2)
SIBP-04 (bevacizumab biosimilar) (1)
E7050 (1)
CM101 (0)
defibrotide (0)
squalamine (0)
ADH-1 (0)
GS-156 (0)
TL-118 (0)
PB101 (0)
RC402 (0)
IOA-289 (0)
ENV-105 (0)
iMX-110 (0)
ACE-041 (0)
sonepcizumab (0)
PG545 (0)
L19-I131 (0)
rifampicin (0)
LB401 (0)
SU5416 (0)
CB1089 (0)
ABT-510 (0)
lurbinectedin (11)
arsenic trioxide (6)
STA-4783 (5)
pelareorep (4)
omacetaxine mepesuccinate (4)
GZ17-6.02 (3)
quaratusugene ozeplasmid (3)
BAL101553 (3)
teserpaturev (1)
IT-141 (1)
Alpha1H (1)
NEO100 (1)
ABI-1968 topical cream (0)
APTO-253 (0)
BP-C1 (0)
BXQ-350 (0)
CM-728 (0)
IL-17E (0)
autologous γδ T lymphocytes (0)
KLTi (0)
MT-3724 (0)
PVT-1 (0)
SVV-001 (0)
alpha-tocopheroloxyacetic acid (0)
darinaparsin (0)
AFP-464 (0)
elemene injection (0)
BAY1862864 (0)
BS-HH-002.SA (0)
PT-112 (0)
K-333 (0)
piceatannol (0)
AP1903 (0)
PRX302 (0)
SJ-C1044 (2)
VB-111 (2)
SIBP-04 (bevacizumab biosimilar) (1)
E7050 (1)
CM101 (0)
defibrotide (0)
squalamine (0)
ADH-1 (0)
GS-156 (0)
TL-118 (0)
PB101 (0)
RC402 (0)
IOA-289 (0)
ENV-105 (0)
iMX-110 (0)
ACE-041 (0)
sonepcizumab (0)
PG545 (0)
L19-I131 (0)
rifampicin (0)
LB401 (0)
SU5416 (0)
CB1089 (0)
ABT-510 (0)
›
Associations
News
Trials
Phase
Status
Apply
Phase
Status
Apply
NEROFE and Doxorubicin in KRAS-mutated ST2-positive Solid Tumors (NCT05661201)
Phase 1
Georgetown University
Georgetown University
Recruiting
Phase 1
Georgetown University
Recruiting
Last update posted :
03/11/2024
Initiation :
04/12/2023
Primary completion :
01/01/2026
Completion :
01/01/2026
KRAS • ST2
|
KRAS mutation
|
doxorubicin hydrochloride • Nerofe (84AA-API 14AA)
Study of NEROFE, a Novel Hormone-Peptide in Adult Patients With Advanced MDS and AML (NCT04365179)
Phase 1b
Immune System Key Ltd
Immune System Key Ltd
Recruiting
Phase 1b
Immune System Key Ltd
Recruiting
Last update posted :
07/22/2022
Initiation :
06/18/2020
Primary completion :
12/30/2022
Completion :
12/30/2022
ST2
|
Nerofe (84AA-API 14AA)
Safety and Efficacy of IV Nerofe™ Followed by Doxorubicin, In Metastatic Ovarian Cancer and Triple Negative Breast Cancer (NCT03634150)
Phase 1b
Immune System Key Ltd
Immune System Key Ltd
Withdrawn
Phase 1b
Immune System Key Ltd
Withdrawn
Last update posted :
10/26/2021
Initiation :
09/06/2018
Primary completion :
04/21/2020
Completion :
04/21/2020
ST2
|
doxorubicin hydrochloride • Nerofe (84AA-API 14AA)
A Phase 2a, Open-Label, Two Stage Study of Nerofe or Nerofe With Doxorubicin in Subjects With AML or MDS (NCT03059615)
Phase 2a
Immune System Key Ltd
Immune System Key Ltd
Withdrawn
Phase 2a
Immune System Key Ltd
Withdrawn
Last update posted :
07/31/2020
Initiation :
10/25/2018
Primary completion :
07/26/2020
Completion :
07/26/2020
ST2
|
doxorubicin hydrochloride • Nerofe (84AA-API 14AA)
Phase 1 Trial of Intravenously Administered Nerofe™ in Subjects With Advanced Malignancies (NCT01690741)
Phase 1
Immune System Key Ltd
Immune System Key Ltd
Completed
Phase 1
Immune System Key Ltd
Completed
Last update posted :
06/25/2018
Initiation :
12/01/2013
Primary completion :
12/19/2017
Completion :
12/19/2017
ST2
|
Nerofe (84AA-API 14AA)
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