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    DRUG:

    Navelbine oral (vinorelbine tartrate oral)

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    Trials

    Company:
    Pierre Fabre
    Drug class:
    Tubulin polymerization inhibitor
    Related drugs:
    Associations
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    Trials

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    Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease (NCT06023641)
    Phase 1/2
    St. Jude Children's Research Hospital
    Recruiting
    Last update posted :
    02/24/2025
    Initiation :
    03/13/2024
    Primary completion :
    10/01/2034
    Completion :
    10/01/2037
    TP53 • FOXO1 • MYOD1
    |
    TP53 mutation
    |
    temozolomide • cyclophosphamide • vincristine • vinorelbine tartrate • dactinomycin • Onivyde (nanoliposomal irinotecan) • Navelbine oral (vinorelbine tartrate oral) • Neupogen (filgrastim)
    Trastuzumab + Alpelisib +/- Fulvestrant vs Trastuzumab + CT in Patients With PIK3CA Mutated Previously Treated HER2+ Advanced BrEasT Cancer (ALPHABET) (NCT05063786)
    Phase 3
    Spanish Breast Cancer Research Group
    Active, not recruiting
    Last update posted :
    02/24/2025
    Initiation :
    09/14/2021
    Primary completion :
    06/01/2025
    Completion :
    06/01/2025
    HER-2 • ER • PIK3CA • PGR
    |
    ER positive • PIK3CA mutation
    |
    Herceptin (trastuzumab) • capecitabine • Piqray (alpelisib) • fulvestrant • Halaven (eribulin mesylate) • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma (ARST2031) (NCT04994132)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    02/18/2025
    Initiation :
    09/14/2021
    Primary completion :
    09/30/2027
    Completion :
    09/30/2027
    FOXO1
    |
    cyclophosphamide • vincristine • dactinomycin • Navelbine oral (vinorelbine tartrate oral)
    Metronomic Oral Vinorelbine Plus Anti-PD-L1/Anti-CTLA4 ImmunothErapy in Patients With Advanced Solid Tumours (MOVIE) (NCT03518606)
    Phase 1/2
    UNICANCER
    Completed
    Last update posted :
    01/15/2025
    Initiation :
    06/20/2018
    Primary completion :
    04/01/2022
    Completion :
    12/19/2024
    TMB
    |
    Imfinzi (durvalumab) • Imjudo (tremelimumab-actl) • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Study of Oral Vinorelbine Plus Capecitabine Versus Taxane-gemcitabine Combinations as 1st Line Chemotherapy in Metastatic Breast Cancer (NCT03887130)
    Phase 2
    Pierre Fabre Medicament
    Completed
    Last update posted :
    04/30/2024
    Initiation :
    03/27/2007
    Primary completion :
    04/18/2013
    Completion :
    04/18/2013
    HER-2
    |
    HER-2 negative
    |
    gemcitabine • paclitaxel • docetaxel • capecitabine • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    MEtronomic TrEatment Option in Advanced bReast cAncer (METEORA-II) (NCT02954055)
    Phase 2
    ETOP IBCSG Partners Foundation
    Completed
    Last update posted :
    02/26/2024
    Initiation :
    09/13/2017
    Primary completion :
    11/17/2021
    Completion :
    11/23/2022
    HER-2 • ER
    |
    ER positive • HER-2 negative
    |
    paclitaxel • capecitabine • cyclophosphamide • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral) • cyclophosphamide intravenous
    Evolutionary Therapy for Rhabdomyosarcoma (NCT04388839)
    Phase 2
    H. Lee Moffitt Cancer Center and Research Insti...
    Recruiting
    Last update posted :
    02/21/2024
    Initiation :
    09/27/2020
    Primary completion :
    12/01/2026
    Completion :
    12/01/2027
    FOXO1
    |
    doxorubicin hydrochloride • cyclophosphamide • irinotecan • vincristine • vinorelbine tartrate • dactinomycin • Navelbine oral (vinorelbine tartrate oral)
    Randomized, Open, Controlled, Multicenter Phase III Clinical Study of Fluzoparib in Combination With Apatinib Versus Investigator-Selected Chemotherapy for HRD-Positive/HER2-negative Advanced Breast Cancer (SYSKY-2023-1016-01) (NCT06255392)
    Phase 3
    Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Un...
    Not yet recruiting
    Last update posted :
    02/13/2024
    Initiation :
    02/01/2024
    Primary completion :
    03/01/2031
    Completion :
    03/01/2031
    BRCA
    |
    gemcitabine • paclitaxel • AiTan (rivoceranib) • capecitabine • Halaven (eribulin mesylate) • AiRuiYi (fluzoparib) • Navelbine oral (vinorelbine tartrate oral)
    Inetetamab Combined With Pyrotinib Plus Oral Vinorelbine for the Treatment of HER2-positive Metastatic Breast Cancer (NCT05823623)
    Phase 2
    The First Affiliated Hospital with Nanjing Medi...
    Recruiting
    Last update posted :
    09/14/2023
    Initiation :
    02/13/2022
    Primary completion :
    12/01/2023
    Completion :
    12/01/2025
    HER-2
    |
    HER-2 positive
    |
    Irene (pyrotinib) • Cipterbin (inetetamab) • Navelbine oral (vinorelbine tartrate oral)
    Efficacy and Safety of Metronomic Oral Vinorelbine Plus Anlotinib in HER2-negative Metastatic Breast Cancer Patients (NCT06015126)
    Phase N/A
    Yan Xue
    Recruiting
    Last update posted :
    08/29/2023
    Initiation :
    10/05/2022
    Primary completion :
    01/01/2025
    Completion :
    01/01/2026
    HER-2
    |
    HER-2 positive • HR positive • HER-2 negative • HR positive + HER-2 negative
    |
    Focus V (anlotinib) • Navelbine oral (vinorelbine tartrate oral)
    Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer (NCT05826964)
    Phase 2
    University of Miami
    Recruiting
    Last update posted :
    08/21/2023
    Initiation :
    06/12/2023
    Primary completion :
    07/31/2026
    Completion :
    07/31/2029
    HER-2 • ER
    |
    HER-2 negative
    |
    Ibrance (palbociclib) • everolimus • tamoxifen • capecitabine • Piqray (alpelisib) • Verzenio (abemaciclib) • Kisqali (ribociclib) • fulvestrant • Halaven (eribulin mesylate) • letrozole • vinorelbine tartrate • anastrozole • exemestane • Orserdu (elacestrant) • Navelbine oral (vinorelbine tartrate oral)
    Metronomic Oral Chemotherapy With Cyclophosphamide, Capecitabine and Vinorelbine in Metastatic Breast Cancer Patients (VEX) (NCT04304352)
    Phase 2
    European Institute of Oncology
    Recruiting
    Last update posted :
    06/28/2023
    Initiation :
    07/29/2011
    Primary completion :
    12/31/2023
    Completion :
    12/31/2023
    ER
    |
    HER-2 overexpression
    |
    capecitabine • cyclophosphamide • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Oral Vinorelbine and Capecitabine in Advanced HER2-negative Breast Cancer (NCT05747326)
    Phase 2
    Cancer Institute and Hospital, Chinese Academy ...
    Recruiting
    Last update posted :
    02/28/2023
    Initiation :
    01/01/2022
    Primary completion :
    06/01/2023
    Completion :
    06/01/2023
    HER-2
    |
    HER-2 negative
    |
    capecitabine • Navelbine oral (vinorelbine tartrate oral)
    Vinorelbine in Mesothelioma (NCT02139904)
    Phase 2
    Wales Cancer Trials Unit
    Completed
    Last update posted :
    10/12/2021
    Initiation :
    03/01/2016
    Primary completion :
    03/17/2021
    Completion :
    03/17/2021
    BRCA1
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Phase II Trial of Oral Vinorelbine in Children With Recurrent or Progressive Unresectable Low-Grade Glioma (OVIMA-1210) (NCT02197637)
    Phase 2
    Centre Oscar Lambret
    Completed
    Last update posted :
    11/18/2020
    Initiation :
    05/01/2014
    Primary completion :
    08/01/2019
    Completion :
    10/01/2020
    ABCB1 • CYP3A5
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Oral Vinorelbine or Capecitabine Combined With Trastuzumab as Adjuvant Treatment for Patients With Lymph Node Negative, HER-2 Positive and Small Tumor Size Breast Cancer (ORCHID) (NCT04296162)
    Phase 2
    Fudan University
    Unknown status
    Last update posted :
    03/05/2020
    Initiation :
    03/01/2019
    Primary completion :
    05/30/2021
    Completion :
    05/30/2021
    HER-2
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • capecitabine • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Gefitinib Versus Vinorelbine/Platinum as Adjuvant Treatment in Stage II-IIIA(N1-N2) NSCLC With EGFR Mutation (ADJUVANT) (NCT01405079)
    Phase 3
    Guangdong Association of Clinical Trials
    Unknown status
    Last update posted :
    02/18/2020
    Initiation :
    09/19/2011
    Primary completion :
    03/01/2017
    Completion :
    12/01/2020
    EGFR
    |
    EGFR mutation • EGFR L858R • EGFR exon 19 deletion
    |
    cisplatin • gefitinib • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Observational Study With Metronomic Oral Vinorelbine in Elderly Patients With Locally Advanced / Metastatic Non-small-cell Lung Cancer (NSCLC) (VINORELBINA) (NCT04208854)
    Phase N/A
    International Group of Endovascular Oncology
    Unknown status
    Last update posted :
    12/26/2019
    Initiation :
    04/18/2018
    Primary completion :
    04/18/2020
    Completion :
    05/18/2020
    EGFR • PD-L1
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Metronomic Treatment With Daily Oral Vinorelbine as First-line Chemotherapy in Patients With Advanced/Metastatic Hormone Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Breast Cancer (VinoMetro) (NCT03007992)
    Phase 2
    Johannes Gutenberg University Mainz
    Completed
    Last update posted :
    08/12/2019
    Initiation :
    12/01/2016
    Primary completion :
    03/02/2019
    Completion :
    03/02/2019
    HER-2 • PGR • ISG20
    |
    HR positive • HER-2 negative
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    GVD±R Regimen for ASCT-eligible Patients With Refractory/Relapsed DLBCL (NCT04021992)
    Phase 2
    Sun Yat-sen University
    Recruiting
    Last update posted :
    08/06/2019
    Initiation :
    07/15/2019
    Primary completion :
    07/15/2023
    Completion :
    12/15/2023
    CD20
    |
    gemcitabine • Rituxan (rituximab) • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Study of Apatinib Combined With Oral Vinorelbine in Metastatic HER2 Negative Breast Cancer (NCT02768415)
    Phase 2
    Chinese Academy of Medical Sciences
    Unknown status
    Last update posted :
    06/19/2019
    Initiation :
    06/01/2016
    Primary completion :
    01/01/2018
    HER-2
    |
    HER-2 negative
    |
    AiTan (rivoceranib) • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Lapatinib in Combination With Oral Vinorelbine for Metastatic Breast Cancer (NCT00912275)
    Phase 1/2
    National Taiwan University Hospital
    Completed
    Last update posted :
    05/06/2019
    Initiation :
    11/24/2008
    Primary completion :
    03/31/2015
    Completion :
    07/07/2017
    HER-2
    |
    HER-2 positive • HER-2 overexpression • HER-2 amplification • HER-2 expression
    |
    lapatinib • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    A Study to Evaluate the Efficacy and Safety of Oral Navelbine in Female Patients With HER2-Negative Metastatic Breast Cancer (NCT03854617)
    Phase 2
    Chinese Academy of Medical Sciences
    Not yet recruiting
    Last update posted :
    02/26/2019
    Initiation :
    02/20/2019
    Primary completion :
    12/20/2021
    Completion :
    12/20/2025
    HER-2
    |
    HER-2 negative
    |
    vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Capecitabine Versus Vinorelbine in High Risk Breast Cancer With Pathologic Residual Tumors After Preoperative Chemotherapy (NCT03703427)
    Phase 2
    Zhiyong Yu
    Not yet recruiting
    Last update posted :
    10/12/2018
    Initiation :
    11/01/2018
    Primary completion :
    11/01/2023
    Completion :
    11/01/2025
    HER-2
    |
    HER-2 positive
    |
    capecitabine • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Phase 0 Study of Metronomic Oral Vinorelbine and Letrozole in HR+/HER2-negative Early Breast Cancer Patients (VENTANA) (NCT02802748)
    Phase 1
    SOLTI Breast Cancer Research Group
    Completed
    Last update posted :
    09/20/2018
    Initiation :
    07/01/2016
    Primary completion :
    01/01/2018
    Completion :
    01/01/2018
    HER-2
    |
    HR positive • HER-2 negative
    |
    letrozole • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Clinical Trial of Neoadjuvant Targeted Treatment to NSCLC Patients (NCT03203590)
    Phase 3
    Sun Yat-sen University
    Not yet recruiting
    Last update posted :
    06/29/2017
    Initiation :
    09/01/2017
    Primary completion :
    01/01/2026
    Completion :
    01/01/2026
    EGFR
    |
    EGFR mutation
    |
    carboplatin • gefitinib • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Maintenance Oral Vinorelbine or Observation After Vinorelbine-Docetaxel First Line Chemotherapy in Advanced Breast Ca (NCT02144194)
    Phase 2
    Cancer Research Group - Collaborative Group, Be...
    Unknown status
    Last update posted :
    02/09/2017
    Initiation :
    03/01/2012
    Primary completion :
    06/01/2017
    Completion :
    12/01/2017
    HER-2
    |
    HER-2 negative
    |
    docetaxel • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Phase II Trial With Metronomic, Capecitabine Plus Oral Vinorelbine for Metastatic Breast Cancer (NCT01941771)
    Phase 2
    University of Aarhus
    Completed
    Last update posted :
    10/28/2016
    Initiation :
    06/01/2012
    Primary completion :
    01/01/2015
    Completion :
    03/01/2015
    HER-2
    |
    HER-2 negative
    |
    capecitabine • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)
    Oral Vinorelbine in Combination With Trastuzumab for Metastatic Breast Cancer (OVINTRA) (NCT01242449)
    Phase 2
    Vejle Hospital
    Completed
    Last update posted :
    05/21/2015
    Initiation :
    11/01/2010
    Primary completion :
    10/01/2012
    Completion :
    10/01/2014
    HER-2
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • vinorelbine tartrate • Navelbine oral (vinorelbine tartrate oral)