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BIOMARKER:

MLH1 mutation

i
Other names: MLH1, COCA2, FCC2, HNPCC, HNPCC2, MutL homolog 1
Entrez ID:
Related biomarkers:
Phase N/A
Memorial Sloan Kettering Cancer Center
Recruiting
Last update posted :
06/14/2024
Initiation :
06/20/2019
Primary completion :
06/01/2024
Completion :
06/01/2024
MLH1 • MSH6 • MSH2 • EPCAM
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 1
Fox Chase Cancer Center
Recruiting
Last update posted :
06/13/2024
Initiation :
09/10/2018
Primary completion :
12/31/2024
Completion :
12/31/2024
MLH1 • MSH6 • MSH2 • EPCAM • CASP3
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
|
atorvastatin
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
06/07/2024
Initiation :
10/16/2017
Primary completion :
04/02/2025
Completion :
04/02/2025
MLH1 • MSH6 • MSH2 • CD4
|
MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation • MSH6 expression
|
Tecentriq (atezolizumab) • Zelboraf (vemurafenib) • 5-fluorouracil • Cotellic (cobimetinib) • oxaliplatin • leucovorin calcium • fluorouracil topical
Phase N/A
White Plains Hospital
Active, not recruiting
Last update posted :
05/24/2024
Initiation :
04/01/2014
Primary completion :
03/01/2024
Completion :
06/01/2024
BRCA1 • BRCA2 • CDKN2A • MLH1 • MSH6 • MSH2 • EPCAM • PRSS1
|
TP53 mutation • BRCA1 mutation • PALB2 mutation • CDKN2A mutation • MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 2
Sidney Kimmel Comprehensive Cancer Center at Jo...
Recruiting
Last update posted :
04/26/2024
Initiation :
01/13/2020
Primary completion :
01/01/2025
Completion :
01/01/2025
TMB • MSI • MLH1 • MSH6 • MSH2 • CDK12
|
MSI-H/dMMR • CDK12 mutation • MSH2 mutation • MLH1 mutation
|
Opdivo (nivolumab)
Phase N/A
George Zogopoulos
Recruiting
Last update posted :
04/17/2024
Initiation :
03/12/2012
Primary completion :
01/01/2025
Completion :
01/01/2025
BRCA1 • BRCA2 • ATM • STK11 • CDKN2A • MLH1 • MSH6 • MSH2 • EPCAM • PRSS1
|
ATM mutation • STK11 mutation • PALB2 mutation • CDKN2A mutation • MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 1/2
National Cancer Institute (NCI)
Recruiting
Last update posted :
04/15/2024
Initiation :
11/10/2022
Primary completion :
07/31/2025
Completion :
07/31/2025
BRAF • MSI • MLH1 • MSH6 • MSH2
|
BRAF mutation • MSH2 mutation • MLH1 mutation • PMS2 mutation
|
NOUS-209
Phase N/A
Beth Israel Deaconess Medical Center
Recruiting
Last update posted :
03/19/2024
Initiation :
07/10/2020
Primary completion :
03/10/2027
Completion :
03/10/2028
BRCA1 • BRCA2 • ATM • STK11 • CDKN2A • MLH1 • MSH6 • MSH2 • BRCA • EPCAM • PRSS1
|
BRCA2 mutation • BRCA1 mutation • PALB2 mutation • CDKN2A mutation • MLH1 mutation • PMS2 mutation • BRCA mutation
Phase 2
M.D. Anderson Cancer Center
Recruiting
Last update posted :
03/13/2024
Initiation :
03/21/2023
Primary completion :
11/30/2025
Completion :
11/30/2025
MSI • MLH1 • MSH6 • MSH2
|
MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation
|
aspirin
Phase 1/2
Asan Medical Center
Completed
Last update posted :
02/28/2024
Initiation :
06/11/2018
Primary completion :
08/30/2023
Completion :
08/30/2023
PD-L1 • MSI • POLE • MLH1 • MSH6 • MSH2 • POLD1 • MSH3 • PMS1 • POLD2
|
MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PD-L1 amplification • POLD1 mutation • MSH3 mutation • PMS2 mutation • MLH3 mutation • PMS1 mutation • POLD2 mutation
|
Imfinzi (durvalumab) • paclitaxel • Imjudo (tremelimumab)
Phase N/A
National Institute of Cancerología
Recruiting
Last update posted :
02/28/2024
Initiation :
03/01/2024
Primary completion :
11/01/2026
Completion :
02/01/2027
TP53 • MSI • POLE • MLH1 • MSH6 • MSH2
|
POLE mutation • MLH1 mutation
Phase N/A
Memorial Sloan Kettering Cancer Center
Active, not recruiting
Last update posted :
02/02/2024
Initiation :
02/01/2015
Primary completion :
02/01/2025
Completion :
02/01/2025
STK11 • MLH1 • MSH6 • MSH2 • SMAD4 • APC • EPCAM • BMPR1A
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase N/A
Mayo Clinic
Recruiting
Last update posted :
01/18/2024
Initiation :
03/30/2022
Primary completion :
04/01/2025
Completion :
04/01/2026
MLH1 • MSH6 • MSH2 • EPCAM
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase N/A
M.D. Anderson Cancer Center
Recruiting
Last update posted :
01/17/2024
Initiation :
04/18/2017
Primary completion :
04/18/2024
Completion :
04/18/2024
ER • PGR • BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • BRIP1 • RAD51C • RAD51D • BARD1
|
BRCA2 mutation • BRCA1 mutation • PALB2 mutation • BRIP1 mutation • MSH2 mutation • RAD51C mutation • MLH1 mutation • RAD51D mutation • PMS2 mutation • BARD1 mutation • RAD51 mutation
Phase N/A
M.D. Anderson Cancer Center
Completed
Last update posted :
01/05/2024
Initiation :
04/04/2018
Primary completion :
01/02/2024
Completion :
01/02/2024
MSI • MLH1 • MSH6 • MSH2 • EPCAM
|
MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 1
Sidney Kimmel Comprehensive Cancer Center at Jo...
Recruiting
Last update posted :
09/04/2023
Initiation :
04/11/2022
Primary completion :
05/01/2026
Completion :
05/01/2026
KRAS • BRCA1 • BRCA2 • ATM • CDKN2A • CD8 • MLH1 • MSH6 • MSH2 • CD4 • EPCAM • PMS1
|
KRAS mutation • PALB2 mutation • CDKN2A mutation • MLH1 mutation • PMS1 mutation
|
Hiltonol (poly-ICLC) • KRAS peptide vaccine
Phase N/A
PERROD Guillaume
Not yet recruiting
Last update posted :
07/27/2023
Initiation :
10/02/2023
Primary completion :
10/02/2023
Completion :
10/02/2025
MSH2
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 2
Spanish Oncology Genito-Urinary Group
Completed
Last update posted :
11/03/2022
Initiation :
02/06/2018
Primary completion :
05/12/2022
Completion :
05/12/2022
BRCA1 • BRCA2 • HRD • MLH1 • MSH6 • MSH2 • CHEK2 • RAD51C
|
CHEK2 mutation • MLH1 mutation
|
Lynparza (olaparib) • docetaxel
Phase 2
Ann-Sofie Backman
Recruiting
Last update posted :
03/28/2022
Initiation :
03/21/2022
Primary completion :
10/15/2028
Completion :
10/15/2038
MLH1 • MSH6 • MSH2 • EPCAM
|
MSH2 mutation • MLH1 mutation
Phase N/A
Fujian Cancer Hospital
Not yet recruiting
Last update posted :
11/23/2021
Initiation :
12/01/2021
Primary completion :
05/01/2023
Completion :
05/01/2023
MLH1 • MSH6 • MSH2 • EPCAM
|
MSH2 mutation • MLH1 mutation • PMS2 mutation • MLH3 mutation
Phase 1
National Cancer Institute (NCI)
Completed
Last update posted :
01/25/2021
Initiation :
01/27/2014
Primary completion :
10/25/2019
Completion :
01/05/2021
MSI • MLH1 • MSH6 • MSH2
|
MSI-H/dMMR • MLH1 mutation • PMS2 mutation
Phase 2
Joanne Jeter
Unknown status
Last update posted :
05/15/2020
Initiation :
08/21/2018
Primary completion :
12/31/2020
Completion :
12/31/2020
MLH1 • MSH2
|
MSH2 mutation • MLH1 mutation
|
Opdivo (nivolumab)
Phase 1
M.D. Anderson Cancer Center
Recruiting
Last update posted :
12/12/2017
Initiation :
01/01/2014
Primary completion :
01/01/2021
MSI • MLH1 • MSH6 • MSH2
|
MSI-H/dMMR • MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase N/A
Rabin Medical Center
Unknown status
Last update posted :
10/17/2017
Initiation :
02/01/2014
Primary completion :
06/01/2018
Completion :
06/01/2019
BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • MSH2 mutation • MLH1 mutation • PMS2 mutation • BRCA mutation
Phase N/A
Wageningen University
Recruiting
Last update posted :
10/06/2017
Initiation :
07/01/2006
Primary completion :
12/01/2030
Completion :
12/01/2030
MLH1 • MSH6 • MSH2 • EPCAM
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase 2
Rabin Medical Center
Not yet recruiting
Last update posted :
09/20/2017
Initiation :
08/01/2016
Primary completion :
07/01/2022
Completion :
07/01/2022
MLH1 • MSH6 • MSH2
|
MSH2 mutation • MLH1 mutation • PMS2 mutation
Phase N/A
National Human Genome Research Institute (NHGRI)
Completed
Last update posted :
07/02/2017
Initiation :
09/28/2005
Completion :
08/02/2010
MSH2
|
MSH2 mutation • MLH1 mutation
Phase N/A
University of Southern California
Completed
Last update posted :
04/11/2017
Initiation :
06/12/2014
Primary completion :
01/05/2017
Completion :
01/05/2017
PTEN • MLH1 • MSH6 • MSH2 • BRCA
|
MSH6 mutation • MLH1 mutation
Phase N/A
University Medical Center Groningen
Completed
Last update posted :
05/13/2016
Initiation :
09/01/2008
Primary completion :
05/01/2016
Completion :
05/01/2016
MLH1 • MSH6 • MSH2
|
MSH6 mutation • MSH2 mutation • MLH1 mutation
Phase 1
University Medical Center Groningen
Completed
Last update posted :
12/09/2014
Initiation :
05/01/2009
Primary completion :
12/01/2014
Completion :
12/01/2014
MLH1 • MSH6 • MSH2
|
MSH2 mutation • MLH1 mutation