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    BIOMARKER:

    MDM4 amplification

    i
    Other names: MDM4, The mouse double minute 4, MDM4 Regulator Of P53, Mdm2-Like P53-Binding Protein, MDM4, P53 Regulator, Double Minute 4, Human Homolog Of; P53-Binding Protein, P53-Binding Protein Mdm4, Double Minute 4 Protein
    Entrez ID:
    4194
    Related biomarkers:
    Expression
    Mutation
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    ALRN-6924 and Paclitaxel in Treating Patients With Advanced, Metastatic, or Unresectable Solid Tumors (NCT03725436)
    Phase 1
    M.D. Anderson Cancer Center
    Active, not recruiting
    Last update posted :
    04/18/2024
    Initiation :
    01/24/2019
    Primary completion :
    04/30/2025
    Completion :
    04/30/2025
    HER-2 • ER • TP53 • MDM2 • MDM4 • GDF15 • CASP3 • CDKN1A
    |
    ER positive • HER-2 negative • TP53 wild-type • MDM4 amplification • MDM2 mutation • TP53 amplification
    |
    paclitaxel • ALRN-6924