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    DRUG:

    lomustine

    i
    Company:
    Generic mfg.
    Drug class:
    Alkylating agent
    Related drugs:
    Apply
    Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma (LEAHRN) (NCT02724579)
    Phase 2
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    02/13/2025
    Initiation :
    11/17/2017
    Primary completion :
    06/30/2027
    Completion :
    06/30/2027
    MYCN • CTNNB1
    |
    CTNNB1 mutation
    |
    cisplatin • cyclophosphamide • vincristine • lomustine • cyclophosphamide intravenous
    A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss (NCT05382338)
    Phase 3
    Children's Oncology Group
    Suspended
    Last update posted :
    02/13/2025
    Initiation :
    02/20/2023
    Primary completion :
    12/20/2027
    Completion :
    12/20/2027
    MYCN • GLI2
    |
    TP53 wild-type
    |
    cisplatin • cyclophosphamide • vincristine • lomustine • mesna
    Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM (SONOBIRD) (NCT05902169)
    Phase 3
    CarThera
    Recruiting
    Last update posted :
    06/12/2024
    Initiation :
    01/29/2024
    Primary completion :
    01/28/2028
    Completion :
    06/30/2028
    BRAF • IDH1
    |
    BRAF mutation • IDH1 R132H • IDH1 R132
    |
    carboplatin • temozolomide • lomustine
    Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression (GLIOASTRA) (NCT05304663)
    Phase 1
    Philogen S.p.A.
    Withdrawn
    Last update posted :
    04/08/2024
    Initiation :
    06/01/2022
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    MGMT
    |
    lomustine • Fibromun (onfekafusp alfa)
    A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression (GLIOSTAR) (NCT04573192)
    Phase 1/2
    Philogen S.p.A.
    Recruiting
    Last update posted :
    04/08/2024
    Initiation :
    02/19/2021
    Primary completion :
    03/01/2025
    Completion :
    12/01/2025
    MGMT
    |
    IDH wild-type
    |
    lomustine • Fibromun (onfekafusp alfa)
    Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM Subjects (NCT03382977)
    Phase 1/2
    VBI Vaccines Inc.
    Recruiting
    Last update posted :
    03/15/2024
    Initiation :
    12/06/2017
    Primary completion :
    07/01/2025
    Completion :
    08/01/2025
    MGMT
    |
    lomustine • carmustine • VBI-1901
    Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma (NCT04910022)
    Phase 1/2
    Nerviano Medical Sciences
    Recruiting
    Last update posted :
    03/15/2024
    Initiation :
    12/01/2021
    Primary completion :
    06/30/2025
    Completion :
    11/30/2025
    EGFR • IDH1 • IDH2 • MGMT • TERT
    |
    EGFR mutation • EGFR amplification • MGMT promoter methylation • TERT mutation • IDH wild-type • TERT promoter mutation
    |
    temozolomide • lomustine • NMS-293
    9-ING-41 in Patients With Advanced Cancers (Actuate 1801) (NCT03678883)
    Phase 2
    Actuate Therapeutics Inc.
    Active, not recruiting
    Last update posted :
    03/11/2024
    Initiation :
    01/04/2019
    Primary completion :
    11/01/2024
    Completion :
    11/01/2025
    BCL2
    |
    carboplatin • gemcitabine • albumin-bound paclitaxel • irinotecan • pegylated liposomal doxorubicin • lomustine • elraglusib (9-ING-41) • doxorubicin liposomal
    Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine®) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma (NRG-BN011) (NCT05095376)
    Phase 3
    NRG Oncology
    Recruiting
    Last update posted :
    01/10/2024
    Initiation :
    11/29/2021
    Primary completion :
    08/08/2026
    Completion :
    08/08/2031
    IDH1 • MGMT
    |
    MGMT promoter methylation • IDH1 R132H • IDH1 R132
    |
    temozolomide • lomustine
    Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed Medulloblastoma (PersoMed-I) (NCT04402073)
    Phase 2
    European Organisation for Research and Treatmen...
    Recruiting
    Last update posted :
    12/11/2023
    Initiation :
    11/11/2022
    Primary completion :
    03/01/2030
    Completion :
    03/01/2030
    TP53 • BRCA2 • MYCN
    |
    TP53 wild-type • MYCN amplification
    |
    cisplatin • vincristine • lomustine • Odomzo (sonidegib)
    A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma Multiforme (NCT04762069)
    Phase 2
    CNS Pharmaceuticals, Inc.
    Active, not recruiting
    Last update posted :
    09/13/2023
    Initiation :
    05/18/2021
    Primary completion :
    09/01/2024
    Completion :
    01/01/2025
    MGMT
    |
    doxorubicin hydrochloride • lomustine • berubicin (RTA 744)
    Effect of Refnot on Immunity in Cancer Patients (R-2) (NCT05898451)
    Phase 2
    Refnot-Pharm Ltd
    Completed
    Last update posted :
    06/12/2023
    Initiation :
    06/04/2009
    Primary completion :
    11/01/2011
    Completion :
    11/01/2011
    CD4
    |
    cisplatin • dacarbazine • lomustine • Zadaxin (thymalfasin)
    Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth Glioblastoma (RIGOLETTO) (NCT04933942)
    Phase 2
    European Organisation for Research and Treatmen...
    Withdrawn
    Last update posted :
    05/24/2023
    Initiation :
    09/13/2022
    Primary completion :
    12/19/2022
    Completion :
    12/19/2022
    IDH1 • MGMT
    |
    MGMT promoter methylation • IDH1 R132H • IDH1 R132
    |
    lomustine • Nplate (romiplostim)
    Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma (NCT01775475)
    Phase 2
    AIDS Malignancy Consortium
    Completed
    Last update posted :
    10/10/2022
    Initiation :
    09/15/2016
    Primary completion :
    04/01/2021
    Completion :
    07/15/2021
    CD4
    |
    doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • prednisone • lomustine • Matulane (procarbazine hydrochloride) • cyclophosphamide intravenous
    Regorafenib in Relapsed Glioblastoma (REGOMA) (NCT02926222)
    Phase 2
    Istituto Oncologico Veneto IRCCS
    Completed
    Last update posted :
    09/09/2022
    Initiation :
    11/01/2015
    Primary completion :
    07/01/2017
    Completion :
    06/01/2021
    MGMT
    |
    Stivarga (regorafenib) • lomustine
    International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma (NCT02066220)
    Phase 2/3
    Universitätsklinikum Hamburg-Eppendorf
    Active, not recruiting
    Last update posted :
    04/19/2022
    Initiation :
    06/01/2014
    Primary completion :
    12/01/2026
    Completion :
    12/01/2026
    MYCN
    |
    cisplatin • carboplatin • doxorubicin hydrochloride • cyclophosphamide • vincristine • lomustine
    A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme (STELLAR) (NCT03025893)
    Phase 2/3
    Amsterdam UMC, location VUmc
    Recruiting
    Last update posted :
    04/19/2021
    Initiation :
    08/31/2018
    Primary completion :
    01/01/2022
    Completion :
    01/01/2022
    MGMT
    |
    MGMT promoter methylation
    |
    sunitinib • lomustine
    Disulfiram in Recurrent Glioblastoma (NCT02678975)
    Phase 2/3
    Sahlgrenska University Hospital, Sweden
    Completed
    Last update posted :
    03/18/2021
    Initiation :
    01/01/2017
    Primary completion :
    01/15/2021
    Completion :
    01/15/2021
    CRP
    |
    temozolomide • lomustine
    Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas (RTOG Foundation 3508) (NCT02343406)
    Phase 2
    AbbVie
    Completed
    Last update posted :
    05/22/2020
    Initiation :
    02/17/2015
    Primary completion :
    06/24/2019
    Completion :
    06/24/2019
    EGFR
    |
    EGFR mutation • EGFR amplification • EGFRvIII mutation
    |
    temozolomide • lomustine • depatuxizumab mafodotin (ABT-414)
    A Comparison of Continuous Bevacizumab (Avastin) Treatment or Placebo in Addition to Lomustine Followed by Standard of Care After Disease Progression in Participants With Glioblastoma (NCT01860638)
    Phase 2
    Hoffmann-La Roche
    Completed
    Last update posted :
    04/30/2018
    Initiation :
    08/19/2013
    Primary completion :
    01/13/2017
    Completion :
    05/05/2017
    PD-1
    |
    Avastin (bevacizumab) • temozolomide • lomustine