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    BIOMARKER:

    KIT exon 13 mutation

    i
    Other names: KIT, C-Kit, CD117, PBT, SCFR, Stem Cell Factor Receptor, V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
    Entrez ID:
    3815
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    Apply
    ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST (NCT05366816)
    Phase 2
    University of Miami
    Recruiting
    Last update posted :
    10/23/2023
    Initiation :
    10/17/2023
    Primary completion :
    12/01/2026
    Completion :
    12/01/2028
    KIT
    |
    KIT exon 13 mutation • KIT exon 17 mutation
    |
    sunitinib • Stivarga (regorafenib)
    cKIT, BRAF/NRAS Mutations in Advanced Melanoma : Clinical Outcome in Response to Tyrosine-kinase Inhibitors - KitMel Project (NCT01543113)
    Phase N/A
    Rennes University Hospital
    Completed
    Last update posted :
    05/24/2023
    Initiation :
    01/01/2011
    Primary completion :
    03/01/2012
    Completion :
    02/01/2014
    KIT • RAS
    |
    NRAS mutation • RAS mutation • KIT exon 11 mutation • KIT exon 13 mutation • KIT exon 17 mutation
    Single Agent Regorafenib in First-line for Metastatic/Unresectable KIT/PDGFR Wild Type GIST (REGISTRI) (NCT02638766)
    Phase 2
    Grupo Espanol de Investigacion en Sarcomas
    Completed
    Last update posted :
    03/27/2023
    Initiation :
    11/01/2015
    Primary completion :
    08/31/2021
    Completion :
    08/31/2021
    KIT
    |
    KIT mutation • KIT exon 13 mutation
    |
    Stivarga (regorafenib)
    PDR001 Plus Imatinib for Metastatic or Unresectable GIST (NCT03609424)
    Phase 1/2
    Asan Medical Center
    Completed
    Last update posted :
    01/02/2023
    Initiation :
    02/14/2019
    Primary completion :
    11/11/2021
    Completion :
    11/11/2021
    KIT • CD8 • PD-1 • LAG3 • ANO1 • MSR1
    |
    KIT mutation • KIT exon 9 mutation • KIT exon 13 mutation
    |
    imatinib • sunitinib • Stivarga (regorafenib) • spartalizumab (PDR001)
    Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors (ZJGIST-01) (NCT04933669)
    Phase 2
    First Affiliated Hospital of Zhejiang University
    Recruiting
    Last update posted :
    10/12/2021
    Initiation :
    09/07/2021
    Primary completion :
    12/31/2029
    Completion :
    12/31/2029
    KIT • PDGFRA • ANO1
    |
    KIT mutation • KIT exon 11 mutation • KIT exon 9 mutation • KIT positive • PDGFRA mutation • KIT exon 13 mutation • KIT exon 17 mutation
    |
    imatinib
    POETIG Trial - POnatinib After rEsisTance to Imatinib in GIST (NCT03171389)
    Phase 2
    Sebastian Bauer
    Unknown status
    Last update posted :
    05/31/2017
    Initiation :
    03/22/2017
    Primary completion :
    09/22/2018
    Completion :
    09/22/2020
    KIT • PDGFRA
    |
    KIT mutation • PDGFRA mutation • KIT exon 13 mutation
    |
    imatinib • sunitinib • Iclusig (ponatinib)