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BIOMARKER:
IDO1 expression
i
Other names:
IDO1, IDO, INDO, Indoleamine 2,3-dioxygenase 1
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Entrez ID:
3620
Related biomarkers:
Expression
‹
›
Associations
(4)
News
Trials
Phase
Status
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Phase
Status
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Epacadostat Before Surgery in Treating Patients With Newly Diagnosed Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (NCT02042430)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 1
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
03/11/2024
Initiation :
08/25/2014
Primary completion :
03/31/2016
Completion :
03/07/2025
IDO1
|
IDO1 expression
|
epacadostat (INCB024360)
Pembrolizumab TX-naive Distant Mets Melanoma and Use of (C11-AMT) PET at Baseline as Imaging Biomarker (NCT03089606)
Phase 2
UNC Lineberger Comprehensive Cancer Center
UNC Lineberger Comprehensive Cancer Center
Completed
Phase 2
UNC Lineberger Comprehensive Cancer Center
Completed
Last update posted :
11/15/2023
Initiation :
04/19/2017
Primary completion :
04/01/2021
Completion :
07/01/2023
LAG3 • HAVCR2 • CD27
|
IDO1 expression
|
Keytruda (pembrolizumab)
Study of Epacadostat (INCB024360) Alone and In Combination With Pembrolizumab (MK-3475) With Chemotherapy and Pembrolizumab Without Chemotherapy in Participants With Advanced Solid Tumors (MK-3475-434) (KEYNOTE-434) (NCT02862457)
Phase 1
Merck Sharp & Dohme LLC
Merck Sharp & Dohme LLC
Completed
Phase 1
Merck Sharp & Dohme LLC
Completed
Last update posted :
08/19/2022
Initiation :
08/23/2016
Primary completion :
11/20/2020
Completion :
11/20/2020
EGFR • PD-L1 • ALK • IDO1
|
IDO1 expression
|
Keytruda (pembrolizumab) • cisplatin • carboplatin • albumin-bound paclitaxel • pemetrexed • epacadostat (INCB024360)
Neoadjuvant Celecoxib in Newly Diagnosed Patients With Endometrial Carcinoma (CELEBRIDO) (NCT03896113)
Phase 2
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cliniques universitaires Saint-Luc- Uni...
Unknown status
Phase 2
Cliniques universitaires Saint-Luc- Université ...
Unknown status
Last update posted :
01/10/2020
Initiation :
11/13/2019
Primary completion :
06/30/2022
Completion :
06/30/2022
CD8 • IDO1 • CD4
|
IDO1 expression
|
celecoxib oral
An Open Label Phase II Study Combining Nivolumab and Celecoxib in Patients With Advanced " Cold " Solid Tumors (NICE-COMBO) (NCT03864575)
Phase 2
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cliniques universitaires Saint-Luc- Uni...
Unknown status
Phase 2
Cliniques universitaires Saint-Luc- Université ...
Unknown status
Last update posted :
07/12/2019
Initiation :
08/15/2019
Primary completion :
06/15/2021
Completion :
06/15/2021
BRAF • IDO1
|
BRAF mutation • IDO1 expression • IDO1 positive
|
Opdivo (nivolumab) • celecoxib oral
Epacadostat and Vaccine Therapy in Treating Patients With Stage III-IV Melanoma (NCT01961115)
Phase 2
Fred Hutchinson Cancer Center
Fred Hutchinson Cancer Center
Completed
Phase 2
Fred Hutchinson Cancer Center
Completed
Last update posted :
06/08/2018
Initiation :
09/13/2013
Primary completion :
10/31/2016
Completion :
05/18/2017
BRAF • CD8 • IFNG • CTLA4 • IDO1 • CD4
|
BRAF V600E • BRAF V600 • CD8 expression • IDO1 expression
|
epacadostat (INCB024360)
Neoadjuvant Combination Biotherapy With Ipilimumab and Nivolumab or Nivolumab Alone (NCT02736123)
Phase 1/2
University of Pittsburgh
University of Pittsburgh
Withdrawn
Phase 1/2
University of Pittsburgh
Withdrawn
Last update posted :
09/20/2017
Initiation :
10/01/2016
Primary completion :
02/09/2017
Completion :
02/09/2017
PD-L1 • CD8 • IDO1
|
PD-L1 expression • IDO1 expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab)
Trial of SBRT With Concurrent Ipilimumab in Metastatic Melanoma (NCT02406183)
Phase 1
Radiotherapie
Radiotherapie
Completed
Phase 1
Radiotherapie
Completed
Last update posted :
01/10/2017
Initiation :
03/01/2015
Primary completion :
08/01/2016
Completion :
08/01/2016
IDO1 • FOXP3
|
IDO1 expression
|
Yervoy (ipilimumab)
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