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    BIOMARKER:

    IDH2 R172K

    i
    Other names: IDH2, Isocitrate Dehydrogenase (NADP(+)) 2, Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial, Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial, Isocitrate Dehydrogenase [NADP], Mitochondrial, Oxalosuccinate Decarboxylase, NADP(+)-Specific ICDH, ICD-M, IDH, IDP, MNADP-IDH, D2HGA2, IDHM, IDPM
    Entrez ID:
    3418
    Related biomarkers:
    Expression
    Mutation
    Others
    Related tests:
    Apply
    Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation (NCI-2019-03057) (NCT03953898)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    06/06/2024
    Initiation :
    08/04/2020
    Primary completion :
    12/01/2024
    Completion :
    12/01/2024
    IDH1 • IDH2
    |
    IDH2 mutation • IDH1 R132H • IDH2 R172K • IDH1 R132C • IDH wild-type • IDH1 R132 • IDH1 R132G • IDH2 R140Q • IDH1 R132L • IDH1 R132S • IDH1 R132V • IDH2 R172 • IDH2 R172G
    |
    Lynparza (olaparib)
    Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations (NCT03212274)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    05/17/2024
    Initiation :
    01/30/2019
    Primary completion :
    07/31/2024
    Completion :
    07/31/2024
    IDH1 • IDH2
    |
    IDH2 mutation • IDH1 R132H • IDH2 R172K • IDH1 R132C • IDH1 R132 • IDH1 R132G • IDH2 R140Q • IDH1 R132L • IDH1 R132S • IDH1 R132V • IDH2 R172 • IDH2 R172G
    |
    Lynparza (olaparib)
    A Study of HMPL-306 in Advanced Hematological Malignancies With mIDH (NCT04764474)
    Phase 1
    Hutchmed
    Recruiting
    Last update posted :
    02/14/2024
    Initiation :
    02/28/2021
    Primary completion :
    09/30/2024
    Completion :
    06/30/2025
    IDH1 • IDH2
    |
    IDH1 R132H • IDH2 R172K • IDH1 R132C • IDH1 R132 • IDH2 R140Q • IDH2 R172
    |
    ranosidenib (HMPL-306)
    Study of Vorasidenib (AG-881) in Participants With Residual or Recurrent Grade 2 Glioma With an IDH1 or IDH2 Mutation (INDIGO) (NCT04164901)
    Phase 3
    Institut de Recherches Internationales Servier
    Active, not recruiting
    Last update posted :
    12/05/2023
    Initiation :
    01/05/2020
    Primary completion :
    09/06/2022
    Completion :
    08/01/2027
    IDH1 • IDH2
    |
    IDH2 mutation • IDH1 R132H • IDH2 R172K • IDH1 R132 • IDH2 R172
    |
    Voranigo (vorasidenib)