[{"id":"60bce1a2-b876-426c-a77f-15b4b5b443a9","acronym":"","url":"https://clinicaltrials.gov/study/NCT03805919","created_at":"2021-01-18T18:48:39.011Z","updated_at":"2025-02-25T15:34:18.012Z","phase":"","brief_title":"Men at High Genetic Risk for Prostate Cancer","source_id_and_acronym":"NCT03805919","lead_sponsor":"National Cancer Institute (NCI)","biomarkers":" TP53 • BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • CHEK2 • FANCA • BRIP1 • RAD51C • RAD51D • EPCAM • NBN • FANCF • FANCL • FANCI • FANCM • FANCD2 • FANCE • FANCG • FANCB • FANCC • HOXB13","pipe":"","alterations":" ","tags":["TP53 • BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • CHEK2 • FANCA • BRIP1 • RAD51C • RAD51D • EPCAM • NBN • FANCF • FANCL • FANCI • FANCM • FANCD2 • FANCE • FANCG • FANCB • FANCC • HOXB13"],"overall_status":"Recruiting","enrollment":" Enrollment 500","initiation":"Initiation: 03/27/2019","start_date":" 03/27/2019","primary_txt":" Primary completion: 01/01/2029","primary_completion_date":" 01/01/2029","study_txt":" Completion: 01/01/2039","study_completion_date":" 01/01/2039","last_update_posted":"2025-02-10"},{"id":"d934aafe-bd3e-4728-955c-fb7a4b80ce12","acronym":"HRPCa-II","url":"https://clinicaltrials.gov/study/NCT05333432","created_at":"2022-04-19T23:53:47.960Z","updated_at":"2025-02-25T17:37:45.989Z","phase":"","brief_title":"Evaluation of a Multimodal Strategy for Early Diagnosis of Men At High Genetic Risk of Prostate Cancer","source_id_and_acronym":"NCT05333432 - HRPCa-II","lead_sponsor":"Assistance Publique - Hôpitaux de Paris","biomarkers":" TP53 • BRCA1 • BRCA2 • PTEN • STK11 • MLH1 • MSH6 • MSH2 • CDH1 • CHEK2 • BRIP1 • RAD51C • RAD50 • RAD51D • BARD1 • NBN • HOXB13","pipe":" | ","alterations":" PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • BARD1 mutation","tags":["TP53 • BRCA1 • BRCA2 • PTEN • STK11 • MLH1 • MSH6 • MSH2 • CDH1 • CHEK2 • BRIP1 • RAD51C • RAD50 • RAD51D • BARD1 • NBN • HOXB13"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • BARD1 mutation"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 880","initiation":"Initiation: 03/01/2025","start_date":" 03/01/2025","primary_txt":" Primary completion: 03/01/2030","primary_completion_date":" 03/01/2030","study_txt":" Completion: 03/01/2030","study_completion_date":" 03/01/2030","last_update_posted":"2025-01-28"},{"id":"adb4d97c-a7e9-49c5-a570-ff5ac230c774","acronym":"","url":"https://clinicaltrials.gov/study/NCT05384535","created_at":"2022-05-20T17:58:29.141Z","updated_at":"2024-07-02T16:35:25.222Z","phase":"","brief_title":"Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort","source_id_and_acronym":"NCT05384535","lead_sponsor":"Northwell Health","biomarkers":" BRCA1 • BRCA2 • BRCA • CHEK2 • HOXB13","pipe":"","alterations":" ","tags":["BRCA1 • BRCA2 • BRCA • CHEK2 • HOXB13"],"overall_status":"Recruiting","enrollment":" Enrollment 100","initiation":"Initiation: 08/15/2022","start_date":" 08/15/2022","primary_txt":" Primary completion: 10/31/2025","primary_completion_date":" 10/31/2025","study_txt":" Completion: 10/31/2026","study_completion_date":" 10/31/2026","last_update_posted":"2023-12-25"},{"id":"a179cee7-5ed4-48d5-8b29-279b434cdab8","acronym":"PROGRESS","url":"https://clinicaltrials.gov/study/NCT05129605","created_at":"2021-11-22T14:53:36.295Z","updated_at":"2024-07-02T16:35:26.710Z","phase":"","brief_title":"Prostate Cancer Genetic Risk Evaluation and Screening Study","source_id_and_acronym":"NCT05129605 - PROGRESS","lead_sponsor":"Massachusetts General Hospital","biomarkers":" TP53 • BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • CHEK2 • FANCA • BRIP1 • RAD51C • RAD51D • EPCAM • NBN • GEN1 • HOXB13","pipe":" | ","alterations":" CHEK2 mutation • BRIP1 mutation • RAD51C mutation • FANCA mutation • RAD51D mutation • PMS2 mutation • NBN mutation","tags":["TP53 • BRCA1 • BRCA2 • MLH1 • MSH6 • MSH2 • CHEK2 • FANCA • BRIP1 • RAD51C • RAD51D • EPCAM • NBN • GEN1 • HOXB13"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CHEK2 mutation • BRIP1 mutation • RAD51C mutation • FANCA mutation • RAD51D mutation • PMS2 mutation • NBN mutation"],"overall_status":"Recruiting","enrollment":" Enrollment 200","initiation":"Initiation: 02/12/2020","start_date":" 02/12/2020","primary_txt":" Primary completion: 12/01/2030","primary_completion_date":" 12/01/2030","study_txt":" Completion: 12/01/2040","study_completion_date":" 12/01/2040","last_update_posted":"2023-12-08"},{"id":"a0f15e3f-28ab-41d6-a204-65043dc006c3","acronym":"HOXB13_Mart","url":"https://clinicaltrials.gov/study/NCT05231915","created_at":"2022-02-09T16:52:45.016Z","updated_at":"2024-07-02T16:35:33.394Z","phase":"","brief_title":"Prevalence of the c.853delT Mutation of the HOXB13 Gene in Prostate Cancer in Martinique","source_id_and_acronym":"NCT05231915 - HOXB13_Mart","lead_sponsor":"University Hospital Center of Martinique","biomarkers":" HOXB13","pipe":"","alterations":" ","tags":["HOXB13"],"overall_status":"Recruiting","enrollment":" Enrollment 465","initiation":"Initiation: 04/09/2021","start_date":" 04/09/2021","primary_txt":" Primary completion: 04/09/2025","primary_completion_date":" 04/09/2025","study_txt":" Completion: 04/09/2025","study_completion_date":" 04/09/2025","last_update_posted":"2023-10-17"},{"id":"74905e23-2b39-450d-9907-3d1958cb0e6d","acronym":"ProFam-Risk","url":"https://clinicaltrials.gov/study/NCT05681416","created_at":"2023-01-12T15:02:15.045Z","updated_at":"2024-07-02T16:35:57.715Z","phase":"","brief_title":"Prostate Cancer Prevention Clinic for Men With Risk of Familial Prostate Cancer","source_id_and_acronym":"NCT05681416 - ProFam-Risk","lead_sponsor":"Heinrich-Heine University, Duesseldorf","biomarkers":" TP53 • BRCA1 • BRCA2 • KIT • ATM • MLH1 • MSH6 • MSH2 • PMS2 • EPCAM • HOXB13","pipe":" | ","alterations":" PMS2 mutation","tags":["TP53 • BRCA1 • BRCA2 • KIT • ATM • MLH1 • MSH6 • MSH2 • PMS2 • EPCAM • HOXB13"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e PMS2 mutation"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 300","initiation":"Initiation: 02/01/2023","start_date":" 02/01/2023","primary_txt":" Primary completion: 02/01/2026","primary_completion_date":" 02/01/2026","study_txt":" Completion: 02/01/2027","study_completion_date":" 02/01/2027","last_update_posted":"2023-01-12"}]