[{"id":"914ea5fe-d76b-491e-9df1-f62ef69fc859","acronym":"PLATPARP","url":"https://clinicaltrials.gov/study/NCT04288687","created_at":"2021-01-18T14:26:42.299Z","updated_at":"2024-07-02T16:35:18.466Z","phase":"Phase 2","brief_title":"A Trial of Niraparib in Platinum-Sensitive Castration-Resistant Prostate Cancer With DNA Repair Defects","source_id_and_acronym":"NCT04288687 - PLATPARP","lead_sponsor":"Abramson Cancer Center at Penn Medicine","biomarkers":" BRCA1 • BRCA2 • CHEK2 • FANCA • BRIP1 • HDAC2","pipe":"","alterations":" ","tags":["BRCA1 • BRCA2 • CHEK2 • FANCA • BRIP1 • HDAC2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Zejula (niraparib)"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 12","initiation":"Initiation: 10/19/2020","start_date":" 10/19/2020","primary_txt":" Primary completion: 06/01/2024","primary_completion_date":" 06/01/2024","study_txt":" Completion: 06/01/2024","study_completion_date":" 06/01/2024","last_update_posted":"2024-02-21"},{"id":"5c9cf0d2-4000-4d44-8b92-7009c77ded0a","acronym":"","url":"https://clinicaltrials.gov/study/NCT04187833","created_at":"2021-01-18T14:26:39.615Z","updated_at":"2024-07-02T16:35:28.977Z","phase":"Phase 2","brief_title":"Nivolumab in Combination With Talazoparib in Melanoma and Mutations in BRCA or BRCA-ness Genes","source_id_and_acronym":"NCT04187833","lead_sponsor":"Case Comprehensive Cancer Center","biomarkers":" TMB • BRCA1 • BRCA2 • BAP1 • MLH1 • CHEK2 • RAD51 • FANCA • BRIP1 • RAD50 • PARP1 • CHEK1 • NBN • HDAC2 • EMSY • ERCC3 • PRKDC • LIG3","pipe":"","alterations":" ","tags":["TMB • BRCA1 • BRCA2 • BAP1 • MLH1 • CHEK2 • RAD51 • FANCA • BRIP1 • RAD50 • PARP1 • CHEK1 • NBN • HDAC2 • EMSY • ERCC3 • PRKDC • LIG3"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Opdivo (nivolumab) • Talzenna (talazoparib)"],"overall_status":"Completed","enrollment":" Enrollment 8","initiation":"Initiation: 06/05/2020","start_date":" 06/05/2020","primary_txt":" Primary completion: 10/13/2023","primary_completion_date":" 10/13/2023","study_txt":" Completion: 10/13/2023","study_completion_date":" 10/13/2023","last_update_posted":"2023-11-16"}]