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    GEF-H1 activator

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    Pembrolizumab in Combination with Plinabulin and Docetaxel for Metastatic NSCLC After ICIs (KeyPemls-004) (NCT05599789)
    Phase 2
    Peking Union Medical College Hospital
    Active, not recruiting
    Last update posted :
    02/18/2025
    Initiation :
    02/01/2023
    Primary completion :
    01/21/2025
    Completion :
    12/31/2025
    EGFR • ALK • ROS1
    |
    Keytruda (pembrolizumab) • docetaxel • plinabulin (BPI 2358)
    Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies (NCT04902040)
    Phase 1/2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    02/14/2024
    Initiation :
    04/14/2021
    Primary completion :
    06/01/2025
    Completion :
    06/01/2025
    MSI
    |
    MSI-H/dMMR
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Tecentriq (atezolizumab) • Imfinzi (durvalumab) • Bavencio (avelumab) • plinabulin (BPI 2358)
    Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT) (NCT05130827)
    Phase 2
    Memorial Sloan Kettering Cancer Center
    Active, not recruiting
    Last update posted :
    08/03/2023
    Initiation :
    12/21/2021
    Primary completion :
    11/01/2025
    Completion :
    11/01/2025
    CD34
    |
    plinabulin (BPI 2358) • Neulasta (pegfilgrastim)
    Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC (DUBLIN-3) (NCT02504489)
    Phase 3
    BeyondSpring Pharmaceuticals Inc.
    Completed
    Last update posted :
    09/10/2022
    Initiation :
    12/01/2015
    Primary completion :
    03/23/2021
    Completion :
    05/23/2021
    EGFR • ALK
    |
    EGFR L858R • EGFR exon 19 deletion • ALK rearrangement
    |
    docetaxel • dexamethasone • plinabulin (BPI 2358)