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    DRUG:

    Fibromun (onfekafusp alfa)

    i
    Other names: L19-TNF, L19TNF, L19TNFalpha, L19 TNF fusion protein
    Company:
    Philogen, Sun Pharma
    Drug class:
    TNFα inhibitor
    Related drugs:
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    Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First Progression (GLIOASTRA) (NCT05304663)
    Phase 1
    Philogen S.p.A.
    Withdrawn
    Last update posted :
    04/08/2024
    Initiation :
    06/01/2022
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    MGMT
    |
    lomustine • Fibromun (onfekafusp alfa)
    A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First Progression (GLIOSTAR) (NCT04573192)
    Phase 1/2
    Philogen S.p.A.
    Recruiting
    Last update posted :
    04/08/2024
    Initiation :
    02/19/2021
    Primary completion :
    03/01/2025
    Completion :
    12/01/2025
    MGMT
    |
    IDH wild-type
    |
    lomustine • Fibromun (onfekafusp alfa)
    Phase 1 Dose-finding Study of L19TNFα Plus Melphalan Using Isolated Inferior Limb Perfusion (ILP) in Subjects With Intransit Stage III/IV Melanoma (NCT01213732)
    Phase 1
    Philogen S.p.A.
    Completed
    Last update posted :
    04/15/2022
    Initiation :
    10/01/2008
    Primary completion :
    03/01/2011
    Completion :
    09/01/2011
    TNFA
    |
    melphalan • Fibromun (onfekafusp alfa)
    L19TNFα in Combination With Doxorubicin in Patients With Advanced Solid Tumours (NCT02076620)
    Phase 1
    Philogen S.p.A.
    Completed
    Last update posted :
    04/04/2022
    Initiation :
    01/16/2013
    Primary completion :
    01/25/2018
    Completion :
    01/25/2018
    TNFA
    |
    doxorubicin hydrochloride • Fibromun (onfekafusp alfa)