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DRUG:
fianlimab (REGN3767)
i
Other names:
REGN3767, REGN 3767, anti-LAG-3 MoAb REGN3767, REGN-3767
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Associations
(2)
News
Trials
Company:
Regeneron, Sanofi
Drug class:
LAG-3 inhibitor
Related drugs:
‹
MGD013 (5)
nivolumab/relatlimab-rmbw (4)
IBI110 (2)
MK-4280 (2)
FS118 (1)
BMS-986016 (1)
ABL501 (0)
CB213 (0)
EMB-02 (0)
GB266 (0)
GLS-012 (0)
HLX26 (0)
IBI-323 (0)
INCA32459 (0)
SHR-1802 (0)
Sym022 (0)
TNRX-257 (0)
ZGGS15 (0)
LBL-007 (0)
XmAb22841 (0)
TSR-033 (0)
MK-4280A (0)
LAG525 (0)
BI 754111 (0)
RG6139 (0)
INCAGN2385 (0)
MGD013 (5)
nivolumab/relatlimab-rmbw (4)
IBI110 (2)
MK-4280 (2)
FS118 (1)
BMS-986016 (1)
ABL501 (0)
CB213 (0)
EMB-02 (0)
GB266 (0)
GLS-012 (0)
HLX26 (0)
IBI-323 (0)
INCA32459 (0)
SHR-1802 (0)
Sym022 (0)
TNRX-257 (0)
ZGGS15 (0)
LBL-007 (0)
XmAb22841 (0)
TSR-033 (0)
MK-4280A (0)
LAG525 (0)
BI 754111 (0)
RG6139 (0)
INCAGN2385 (0)
›
Associations
(2)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
Androgen Deprivation, With or Without pTVG-AR, and With or Without T-Cell Checkpoint Blockade, in Patients With Newly Diagnosed, High-Risk Prostate Cancer (NCT04989946)
Phase 1/2
University of Wisconsin, Madison
University of Wisconsin, Madison
Recruiting
Phase 1/2
University of Wisconsin, Madison
Recruiting
Last update posted :
02/07/2025
Initiation :
12/16/2021
Primary completion :
12/01/2026
Completion :
12/01/2028
CD8
|
Opdivo (nivolumab) • Libtayo (cemiplimab-rwlc) • Firmagon (degarelix) • fianlimab (REGN3767) • MVI-118
A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer (NCT05800015)
Phase 2/3
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals
Recruiting
Phase 2/3
Regeneron Pharmaceuticals
Recruiting
Last update posted :
01/31/2025
Initiation :
08/08/2023
Primary completion :
01/16/2030
Completion :
12/23/2031
PD-L1
|
PD-L1 expression
|
cisplatin • carboplatin • paclitaxel • pemetrexed • Libtayo (cemiplimab-rwlc) • fianlimab (REGN3767)
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (NCT06769698)
Phase 2
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals
Not yet recruiting
Phase 2
Regeneron Pharmaceuticals
Not yet recruiting
Last update posted :
01/10/2025
Initiation :
03/26/2025
Primary completion :
04/22/2027
Completion :
11/28/2029
PD-L1
|
Libtayo (cemiplimab-rwlc) • fianlimab (REGN3767)
I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) (NCT01042379)
Phase 2
QuantumLeap Healthcare Collaborative
QuantumLeap Healthcare Collaborative
Recruiting
Phase 2
QuantumLeap Healthcare Collaborative
Recruiting
Last update posted :
10/22/2024
Initiation :
03/01/2010
Primary completion :
12/01/2030
Completion :
12/01/2031
HER-2 • ER
|
ER positive • ER negative
|
Keytruda (pembrolizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • carboplatin • Imfinzi (durvalumab) • paclitaxel • Nerlynx (neratinib) • Perjeta (pertuzumab) • Kadcyla (ado-trastuzumab emtansine) • doxorubicin hydrochloride • Talzenna (talazoparib) • Verzenio (abemaciclib) • Zejula (niraparib) • cyclophosphamide • irinotecan • Jemperli (dostarlimab-gxly) • Tukysa (tucatinib) • letrozole • veliparib (ABT-888) • Libtayo (cemiplimab-rwlc) • MK-2206 • Datroway (datopotamab deruxtecan) • Ziihera (zanidatamab-hrii) • ganitumab (AMG 479) • amcenestrant (SAR439859) • anvatabart opadotin (JNJ-0683) • metformin • Jivadco (trastuzumab duocarmazine) • Turalio (pexidartinib) • ganetespib (ADX-1612) • vepdegestrant (ARV-471) • Cosela (trilaciclib) • Fablyn (lasofoxifene) • DAN-222 • fianlimab (REGN3767) • Oraxol (oral paclitaxel/encequidar) • ladiratuzumab vedotin (SGN-LIV1A) • nelitolimod (SD-101) • patritumab (U3-1287) • rilvegostomig (AZD2936) • trebananib (AMG 386) • Kevzara (sarilumab) • Voyager-V1
A Study to Learn if a Combination of Fianlimab and Cemiplimab Versus Cemiplimab Alone is More Effective for Adult Participants With Advanced Non-Small Cell Lung Cancer (NSCLC) (R3767-ONC-2235) (NCT05785767)
Phase 2/3
Regeneron Pharmaceuticals
Regeneron Pharmaceuticals
Recruiting
Phase 2/3
Regeneron Pharmaceuticals
Recruiting
Last update posted :
05/29/2024
Initiation :
06/30/2023
Primary completion :
03/11/2030
Completion :
02/05/2032
PD-L1
|
Libtayo (cemiplimab-rwlc) • fianlimab (REGN3767)
89Zr-DFO-REGN3767 in PET Scans in People With Diffuse Large B Cell Lymphoma (DLBCL) (NCT04566978)
Phase 1
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Active, not recruiting
Phase 1
Memorial Sloan Kettering Cancer Center
Active, not recruiting
Last update posted :
10/17/2023
Initiation :
09/11/2020
Primary completion :
09/11/2025
Completion :
09/11/2025
LAG3
|
LAG3 expression
|
fianlimab (REGN3767)
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