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DRUG:
Erbitux (cetuximab)
i
Other names:
C 225, IMC-C225, LY2939777, C225-03, ch225, C225, IMC C225, LY-2939777, IMCC225, LY 2939777, C-225
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Associations
(347)
News
Trials
Company:
BMS, EMD Serono, Eli Lilly
Drug class:
EGFR inhibitor
Related drugs:
‹
osimertinib (301)
erlotinib (235)
afatinib (227)
gefitinib (194)
panitumumab (123)
lapatinib (107)
neratinib (102)
pyrotinib (79)
brigatinib (50)
icotinib (45)
aumolertinib (39)
amivantamab-vmjw (25)
firmonertinib (14)
mobocertinib (12)
lazertinib (12)
BGB-283 (12)
tarloxotinib bromide (7)
WZ4002 (7)
CH7233163 (6)
H002 (6)
nimotuzumab (6)
BLU-945 (6)
ASLAN001 (6)
BBT-176 (5)
CL-387785 (5)
GB263T (5)
rociletinib (5)
BDTX-189 (5)
AEE788 (4)
BDTX-1535 (4)
BI-4020 (4)
tomuzotuximab (4)
JIN-A02 (4)
VRN11 (4)
MET306 (4)
EGF816 (4)
AFM24 (3)
BLU-701 (3)
GC-1118A (3)
necitumumab (3)
befotertinib (3)
zorifertinib (3)
BCA101 (3)
S95026 (3)
ASP8273 (3)
MCLA-129 (3)
DZD9008 (3)
SZMD4 (3)
ACE2016 (2)
BI-732 (2)
BLU-451 (2)
Bay846 (2)
ERAS-801 (2)
OBX02-011 (2)
olmutinib (2)
QL1203 (2)
CLN-081 (2)
14aj (1)
αEGFR (1)
ABP 494 (cetuximab biosimilar) (1)
APL-103 (1)
BAY 2927088 (1)
BPI-15086 (1)
BPI-361175 (1)
Compound 6a (1)
abivertinib (1)
KKI04 (1)
PH001 (1)
rilertinib (1)
TAS3351 (1)
TRX-221 (1)
WSD0922 (1)
JMT101 (1)
RT1978 (1)
HMPL-813 (1)
SI-B001 (1)
ASK120067 (1)
HLX07 (1)
Hemay022 (1)
KD019 (1)
ABT-101 (0)
AC480 (0)
AG1478 (0)
BBT-207 (0)
BC3448 (0)
BMS690514 (0)
BNA035 (0)
CM93 (0)
CUDC-101 (0)
EGF-PTI (0)
DF9001 (0)
EGFR (0)
STI-001 (cetuximab biosimilar) (0)
FHND9041 (0)
HS-10375 (0)
antroquinonol (0)
zalutumumab (0)
IAE0972 (0)
IBI-334 (0)
JANX008 (0)
JNJ-26483327 (0)
JS111 (0)
asandeutertinib (0)
MM-151 (0)
MP412 (0)
MTX-211 (0)
PF-08046052 (0)
PLB1004 (0)
PM1080 (0)
QLH11811 (0)
rindopepimut (0)
SR13668 (0)
SYN004 (0)
Sym013 (0)
TAK-186 (0)
TAK-285 (0)
TAS-121 (0)
TAVO412 (0)
THE-349 (0)
TQ-B3456 (0)
TQB3804 (0)
U3-1565 (0)
Undisclosed EGFR inhibitor (0)
XZP-5809 (0)
simotinib (0)
ZN-e4 (0)
AST1306 (0)
SY101 (0)
Ami-LC (0)
EMB-01 (0)
cetuximab biosimilar (0)
cipatinib (0)
ABT-806 (0)
MEHD7945A (0)
RO5083945 (0)
TL007 (0)
EMD 72000 (0)
PF-06747775 (0)
JNJ-64041757 (0)
KBP-5209 (0)
SKLB-1028 (0)
AZD8931 (0)
osimertinib (301)
erlotinib (235)
afatinib (227)
gefitinib (194)
panitumumab (123)
lapatinib (107)
neratinib (102)
pyrotinib (79)
brigatinib (50)
icotinib (45)
aumolertinib (39)
amivantamab-vmjw (25)
firmonertinib (14)
mobocertinib (12)
lazertinib (12)
BGB-283 (12)
tarloxotinib bromide (7)
WZ4002 (7)
CH7233163 (6)
H002 (6)
nimotuzumab (6)
BLU-945 (6)
ASLAN001 (6)
BBT-176 (5)
CL-387785 (5)
GB263T (5)
rociletinib (5)
BDTX-189 (5)
AEE788 (4)
BDTX-1535 (4)
BI-4020 (4)
tomuzotuximab (4)
JIN-A02 (4)
VRN11 (4)
MET306 (4)
EGF816 (4)
AFM24 (3)
BLU-701 (3)
GC-1118A (3)
necitumumab (3)
befotertinib (3)
zorifertinib (3)
BCA101 (3)
S95026 (3)
ASP8273 (3)
MCLA-129 (3)
DZD9008 (3)
SZMD4 (3)
ACE2016 (2)
BI-732 (2)
BLU-451 (2)
Bay846 (2)
ERAS-801 (2)
OBX02-011 (2)
olmutinib (2)
QL1203 (2)
CLN-081 (2)
14aj (1)
αEGFR (1)
ABP 494 (cetuximab biosimilar) (1)
APL-103 (1)
BAY 2927088 (1)
BPI-15086 (1)
BPI-361175 (1)
Compound 6a (1)
abivertinib (1)
KKI04 (1)
PH001 (1)
rilertinib (1)
TAS3351 (1)
TRX-221 (1)
WSD0922 (1)
JMT101 (1)
RT1978 (1)
HMPL-813 (1)
SI-B001 (1)
ASK120067 (1)
HLX07 (1)
Hemay022 (1)
KD019 (1)
ABT-101 (0)
AC480 (0)
AG1478 (0)
BBT-207 (0)
BC3448 (0)
BMS690514 (0)
BNA035 (0)
CM93 (0)
CUDC-101 (0)
EGF-PTI (0)
DF9001 (0)
EGFR (0)
STI-001 (cetuximab biosimilar) (0)
FHND9041 (0)
HS-10375 (0)
antroquinonol (0)
zalutumumab (0)
IAE0972 (0)
IBI-334 (0)
JANX008 (0)
JNJ-26483327 (0)
JS111 (0)
asandeutertinib (0)
MM-151 (0)
MP412 (0)
MTX-211 (0)
PF-08046052 (0)
PLB1004 (0)
PM1080 (0)
QLH11811 (0)
rindopepimut (0)
SR13668 (0)
SYN004 (0)
Sym013 (0)
TAK-186 (0)
TAK-285 (0)
TAS-121 (0)
TAVO412 (0)
THE-349 (0)
TQ-B3456 (0)
TQB3804 (0)
U3-1565 (0)
Undisclosed EGFR inhibitor (0)
XZP-5809 (0)
simotinib (0)
ZN-e4 (0)
AST1306 (0)
SY101 (0)
Ami-LC (0)
EMB-01 (0)
cetuximab biosimilar (0)
cipatinib (0)
ABT-806 (0)
MEHD7945A (0)
RO5083945 (0)
TL007 (0)
EMD 72000 (0)
PF-06747775 (0)
JNJ-64041757 (0)
KBP-5209 (0)
SKLB-1028 (0)
AZD8931 (0)
›
Associations
(347)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC (NCT04091867)
Phase 1
University of Colorado, Denver
University of Colorado, Denver
Completed
Phase 1
University of Colorado, Denver
Completed
Last update posted :
02/24/2025
Initiation :
01/06/2020
Primary completion :
05/14/2021
Completion :
10/25/2022
EPHB4
|
EGFR expression • CDKN2A negative
|
Erbitux (cetuximab) • cisplatin • carboplatin • sEphB4-HSA
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers (ECOG-ACRIN EA3202) (NCT05063552)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
03/13/2023
Primary completion :
12/15/2027
Completion :
12/15/2027
PD-L1
|
PD-L1 expression
|
Avastin (bevacizumab) • Erbitux (cetuximab) • cisplatin • Tecentriq (atezolizumab) • carboplatin • docetaxel • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn)
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06179160)
Phase 1
Incyte Corporation
Incyte Corporation
Recruiting
Phase 1
Incyte Corporation
Recruiting
Last update posted :
02/21/2025
Initiation :
01/04/2024
Primary completion :
01/01/2027
Completion :
01/01/2027
KRAS
|
Erbitux (cetuximab) • irinotecan • Zynyz (retifanlimab-dlwr)
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (MOUNTAINEER-03) (NCT05253651)
Phase 3
Seagen Inc.
Seagen Inc.
Recruiting
Phase 3
Seagen Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
10/24/2022
Primary completion :
04/03/2026
Completion :
07/27/2029
HER-2
|
RAS wild-type
|
Avastin (bevacizumab) • Herceptin (trastuzumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • Tukysa (tucatinib) • leucovorin calcium • levoleucovorin calcium
A Phase I/IIa Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD0022 as Monotherapy and in Combination With Anti-cancer Agents in Adult Participants With Tumours Harbouring a KRASG12D Mutation (ALAFOSS-01) (NCT06599502)
Phase 1/2
AstraZeneca
AstraZeneca
Recruiting
Phase 1/2
AstraZeneca
Recruiting
Last update posted :
02/20/2025
Initiation :
10/18/2024
Primary completion :
01/20/2028
Completion :
01/20/2028
KRAS
|
KRAS mutation • KRAS G12D
|
Erbitux (cetuximab)
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer (BREAKWATER) (NCT04607421)
Phase 3
Pfizer
Pfizer
Active, not recruiting
Phase 3
Pfizer
Active, not recruiting
Last update posted :
02/20/2025
Initiation :
12/21/2020
Primary completion :
01/06/2025
Completion :
12/24/2026
BRAF
|
BRAF V600E • BRAF V600
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • capecitabine • Braftovi (encorafenib) • oxaliplatin • irinotecan • leucovorin calcium • Zirabev (bevacizumab-bvzr) • Khapzory (levoleucovorin) • levoleucovorin calcium
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer (RTOG 1216) (NCT01810913)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/20/2025
Initiation :
03/22/2013
Primary completion :
01/01/2027
Completion :
01/01/2027
EGFR • CD4
|
CDKN2A negative
|
Erbitux (cetuximab) • cisplatin • Tecentriq (atezolizumab) • docetaxel • Datalai (cetuximab biosimilar)
A Study to Evaluate INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06818812)
Phase 1
Incyte Corporation
Incyte Corporation
Not yet recruiting
Phase 1
Incyte Corporation
Not yet recruiting
Last update posted :
02/19/2025
Initiation :
03/10/2025
Primary completion :
03/27/2027
Completion :
03/27/2027
KRAS
|
Erbitux (cetuximab) • irinotecan
EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer (NCT06011772)
Phase 1
Roswell Park Cancer Institute
Roswell Park Cancer Institute
Suspended
Phase 1
Roswell Park Cancer Institute
Suspended
Last update posted :
02/19/2025
Initiation :
12/04/2023
Primary completion :
12/04/2025
Completion :
12/04/2026
KRAS • BRAF • RAS
|
BRAF V600 • KRAS wild-type • BRAF wild-type • RAS wild-type • NRAS wild-type
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium • CimaVax EGF (EGF-PTI)
Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer (NCT06833866)
Phase 1
The Methodist Hospital Research Institute
The Methodist Hospital Research Institute
Recruiting
Phase 1
The Methodist Hospital Research Institute
Recruiting
Last update posted :
02/19/2025
Initiation :
12/04/2024
Primary completion :
06/01/2025
Completion :
12/01/2025
CD8 • CD4
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan
Avelumab with or Without Cetuximab in Treating Patients with Advanced Skin Squamous Cell Cancer (NCT03944941)
Phase 2
Alliance for Clinical Trials in Oncology
Alliance for Clinical Trials in Oncology
Active, not recruiting
Phase 2
Alliance for Clinical Trials in Oncology
Active, not recruiting
Last update posted :
02/18/2025
Initiation :
06/17/2019
Primary completion :
12/01/2026
Completion :
12/01/2028
PD-L1 • CD4
|
Erbitux (cetuximab) • Bavencio (avelumab)
A Study to Test Whether Different Combinations of BI 765063, Ezabenlimab, Chemotherapy, Cetuximab, and BI 836880 Help People With Head and Neck Cancer or Liver Cancer (NCT05249426)
Phase 1
Boehringer Ingelheim
Boehringer Ingelheim
Active, not recruiting
Phase 1
Boehringer Ingelheim
Active, not recruiting
Last update posted :
02/18/2025
Initiation :
04/12/2022
Primary completion :
07/16/2024
Completion :
08/02/2025
SIRPA
|
Erbitux (cetuximab) • Tecentriq (atezolizumab) • paclitaxel • docetaxel • capecitabine • ezabenlimab (BI 754091) • BI 765063 • BI 836880
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer (NCT06102902)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 1
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/17/2025
Initiation :
06/05/2024
Primary completion :
06/30/2025
Completion :
06/30/2025
BRAF
|
BRAF V600E
|
Erbitux (cetuximab) • Braftovi (encorafenib) • ZEN-3694
Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal Cancer (NCT03290937)
Phase 1
M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
Active, not recruiting
Phase 1
M.D. Anderson Cancer Center
Active, not recruiting
Last update posted :
02/17/2025
Initiation :
12/27/2017
Primary completion :
12/31/2026
Completion :
12/31/2026
MSI
|
MSI-H/dMMR • RAS mutation
|
Erbitux (cetuximab) • irinotecan • utomilumab (PF-05082566) • Datalai (cetuximab biosimilar)
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation (GO42144) (NCT04449874)
Phase 1
Genentech, Inc.
Genentech, Inc.
Recruiting
Phase 1
Genentech, Inc.
Recruiting
Last update posted :
02/14/2025
Initiation :
07/29/2020
Primary completion :
02/28/2026
Completion :
02/28/2026
KRAS
|
KRAS mutation • KRAS G12C • KRAS G12
|
Avastin (bevacizumab) • Erbitux (cetuximab) • Tecentriq (atezolizumab) • erlotinib • divarasib (RG6330) • Itovebi (inavolisib) • migoprotafib (RLY-1971)
Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab. (ECLYPse) (NCT06640166)
Phase 2
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fondazione Policlinico Universitario Ag...
Recruiting
Phase 2
Fondazione Policlinico Universitario Agostino G...
Recruiting
Last update posted :
02/12/2025
Initiation :
06/03/2024
Primary completion :
12/31/2025
Completion :
06/30/2026
BRAF
|
Erbitux (cetuximab) • 5-fluorouracil • Braftovi (encorafenib) • irinotecan • leucovorin calcium
A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies (HERKULES-3) (NCT05039177)
Phase 1/2
Erasca, Inc.
Erasca, Inc.
Active, not recruiting
Phase 1/2
Erasca, Inc.
Active, not recruiting
Last update posted :
02/11/2025
Initiation :
09/20/2021
Primary completion :
08/01/2025
Completion :
12/01/2025
KRAS • BRAF • NRAS
|
BRAF V600E • KRAS mutation • NRAS mutation • BRAF V600
|
Erbitux (cetuximab) • Ibrance (palbociclib) • Braftovi (encorafenib) • ERAS-007
Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10) (NCT04793958)
Phase 3
Mirati Therapeutics Inc.
Mirati Therapeutics Inc.
Active, not recruiting
Phase 3
Mirati Therapeutics Inc.
Active, not recruiting
Last update posted :
02/11/2025
Initiation :
06/24/2021
Primary completion :
01/30/2026
Completion :
01/30/2026
KRAS
|
KRAS mutation • KRAS G12C • KRAS G12
|
Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • Krazati (adagrasib) • leucovorin calcium
A Study of MK-1084 in KRAS Mutant Advanced Solid Tumors (MK-1084-001) (NCT05067283)
Phase 1
Merck Sharp & Dohme LLC
Merck Sharp & Dohme LLC
Recruiting
Phase 1
Merck Sharp & Dohme LLC
Recruiting
Last update posted :
02/11/2025
Initiation :
12/17/2021
Primary completion :
08/19/2027
Completion :
08/19/2027
PD-L1 • KRAS
|
KRAS mutation • KRAS G12C • KRAS G12
|
Keytruda (pembrolizumab) • Erbitux (cetuximab) • carboplatin • 5-fluorouracil • pemetrexed • oxaliplatin • leucovorin calcium • MK-1084
QTX3046 in Patients with KRAS G12D Mutations (NCT06428500)
Phase 1
Quanta Therapeutics
Quanta Therapeutics
Recruiting
Phase 1
Quanta Therapeutics
Recruiting
Last update posted :
02/10/2025
Initiation :
05/30/2024
Primary completion :
07/01/2027
Completion :
07/01/2027
KRAS
|
Erbitux (cetuximab) • QTX3046
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (OrigAMI-2) (NCT06662786)
Phase 3
Janssen Research & Development, LLC
Janssen Research & Development, LLC
Recruiting
Phase 3
Janssen Research & Development, LLC
Recruiting
Last update posted :
02/10/2025
Initiation :
10/18/2024
Primary completion :
12/15/2028
Completion :
12/15/2032
BRAF
|
Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • Rybrevant (amivantamab-vmjw) • leucovorin calcium • levoleucovorin calcium
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)
Phase 1
Pfizer
Pfizer
Recruiting
Phase 1
Pfizer
Recruiting
Last update posted :
02/10/2025
Initiation :
07/05/2022
Primary completion :
09/23/2026
Completion :
03/26/2028
BRAF
|
Erbitux (cetuximab) • Mektovi (binimetinib) • PF-07799933
TTX-080 HLA-G Antagonist in Subjects with Advanced Cancers (TTX-080-001) (NCT04485013)
Phase 1
Tizona Therapeutics, Inc
Tizona Therapeutics, Inc
Recruiting
Phase 1
Tizona Therapeutics, Inc
Recruiting
Last update posted :
02/07/2025
Initiation :
07/14/2020
Primary completion :
06/01/2027
Completion :
06/01/2027
BRAF
|
Keytruda (pembrolizumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium • TTX-080
A Phase 1b Study of WU-NK-101 in Combination With Cetuximab (NCT05674526)
Phase 1
Wugen, Inc.
Wugen, Inc.
Recruiting
Phase 1
Wugen, Inc.
Recruiting
Last update posted :
02/07/2025
Initiation :
05/21/2024
Primary completion :
09/30/2025
Completion :
06/01/2026
EGFR • BRAF
|
BRAF V600E • BRAF V600 • EGFR expression • RAS mutation
|
Erbitux (cetuximab) • WU-NK-101
A Study of ASP3082 in Adults With Advanced Solid Tumors (3082-CL-0101) (NCT05382559)
Phase 1
Astellas Pharma Inc
Astellas Pharma Inc
Recruiting
Phase 1
Astellas Pharma Inc
Recruiting
Last update posted :
02/05/2025
Initiation :
06/08/2022
Primary completion :
10/31/2026
Completion :
10/31/2026
KRAS
|
KRAS mutation • KRAS G12D • KRAS G12
|
Erbitux (cetuximab) • gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • ASP3082
A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation. (NCT06447662)
Phase 1
Pfizer
Pfizer
Recruiting
Phase 1
Pfizer
Recruiting
Last update posted :
02/04/2025
Initiation :
06/27/2024
Primary completion :
07/30/2027
Completion :
07/29/2028
KRAS
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Erbitux (cetuximab) • cisplatin • carboplatin • gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • pemetrexed • oxaliplatin • leucovorin calcium
A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene (NCT06704724)
Phase 1
Pfizer
Pfizer
Recruiting
Phase 1
Pfizer
Recruiting
Last update posted :
02/04/2025
Initiation :
12/10/2024
Primary completion :
01/30/2028
Completion :
01/29/2029
KRAS
|
Keytruda (pembrolizumab) • Avastin (bevacizumab) • Erbitux (cetuximab) • cisplatin • carboplatin • gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • pemetrexed • oxaliplatin • leucovorin calcium • sasanlimab (PF-06801591) • PF-07284892
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3) (NCT06750094)
Phase 3
Janssen Research & Development, LLC
Janssen Research & Development, LLC
Recruiting
Phase 3
Janssen Research & Development, LLC
Recruiting
Last update posted :
02/03/2025
Initiation :
12/12/2024
Primary completion :
12/15/2027
Completion :
04/13/2029
BRAF
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • irinotecan • Rybrevant (amivantamab-vmjw) • leucovorin calcium • levoleucovorin calcium
ZN-c3 in Adult Participants With Metastatic Colorectal Cancer (ZN-c3-016) (NCT05743036)
Phase 1
K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc
K-Group, Beta, Inc., a wholly owned sub...
Active, not recruiting
Phase 1
K-Group, Beta, Inc., a wholly owned subsidiary ...
Active, not recruiting
Last update posted :
02/03/2025
Initiation :
02/27/2023
Primary completion :
07/16/2024
Completion :
09/25/2026
BRAF
|
BRAF V600E • BRAF V600
|
Erbitux (cetuximab) • Braftovi (encorafenib) • azenosertib (ZN-c3)
Sequential Treatment Strategy for Metastatic Colorectal Cancer (ITACa) (NCT01878422)
Phase 3
Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori
Istituto Scientifico Romagnolo per lo S...
Completed
Phase 3
Istituto Scientifico Romagnolo per lo Studio e ...
Completed
Last update posted :
01/31/2025
Initiation :
11/01/2007
Primary completion :
03/01/2014
Completion :
06/11/2016
KRAS
|
Avastin (bevacizumab) • Erbitux (cetuximab) • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors (NCT02671435)
Phase 1/2
MedImmune LLC
MedImmune LLC
Active, not recruiting
Phase 1/2
MedImmune LLC
Active, not recruiting
Last update posted :
01/30/2025
Initiation :
02/22/2016
Primary completion :
10/26/2021
Completion :
09/01/2025
BRAF
|
PD-L1 expression
|
Avastin (bevacizumab) • Erbitux (cetuximab) • Imfinzi (durvalumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium • monalizumab (IPH2201)
PhII ICb With/Without Erbitux in MBC Pts (CA225200) (NCT00248287)
Phase 2
US Oncology Research
US Oncology Research
Active, not recruiting
Phase 2
US Oncology Research
Active, not recruiting
Last update posted :
01/29/2025
Initiation :
07/28/2005
Primary completion :
12/01/2025
Completion :
12/01/2026
EGFR • HER-2 • PGR
|
HER-2 negative
|
Erbitux (cetuximab) • cisplatin • carboplatin • irinotecan
Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor (NCT04966481)
Phase 3
Washington University School of Medicine
Washington University School of Medicine
Recruiting
Phase 3
Washington University School of Medicine
Recruiting
Last update posted :
01/29/2025
Initiation :
04/06/2022
Primary completion :
02/28/2027
Completion :
02/28/2027
CDKN2A
|
CDKN2A negative
|
Erbitux (cetuximab) • Ibrance (palbociclib)
Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C) (KEYNOTE E27) (NCT04956640)
Phase 1/2
Eli Lilly and Company
Eli Lilly and Company
Recruiting
Phase 1/2
Eli Lilly and Company
Recruiting
Last update posted :
01/28/2025
Initiation :
07/19/2021
Primary completion :
06/01/2026
Completion :
06/01/2026
KRAS
|
KRAS mutation • KRAS G12C • KRAS G12
|
Keytruda (pembrolizumab) • Erbitux (cetuximab) • cisplatin • erlotinib • carboplatin • Tyvyt (sintilimab) • Verzenio (abemaciclib) • pemetrexed • batoprotafib (TNO155) • temuterkib (LY3214996) • LY3295668 • olomorasib (LY3537982)
A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors (MOONRAY-01) (NCT06586515)
Phase 1
Eli Lilly and Company
Eli Lilly and Company
Recruiting
Phase 1
Eli Lilly and Company
Recruiting
Last update posted :
01/28/2025
Initiation :
09/12/2024
Primary completion :
03/01/2029
Completion :
03/01/2029
KRAS
|
Erbitux (cetuximab) • gemcitabine • 5-fluorouracil • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium
A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors (NCT06607185)
Phase 1
Eli Lilly and Company
Eli Lilly and Company
Recruiting
Phase 1
Eli Lilly and Company
Recruiting
Last update posted :
01/28/2025
Initiation :
10/21/2024
Primary completion :
01/01/2030
Completion :
01/01/2030
KRAS
|
Keytruda (pembrolizumab) • Erbitux (cetuximab) • cisplatin • carboplatin • gemcitabine • albumin-bound paclitaxel • pemetrexed • oxaliplatin • irinotecan • leucovorin calcium
Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC (BRICKET) (NCT06578559)
Phase 2
Gruppo Oncologico del Nord-Ovest
Gruppo Oncologico del Nord-Ovest
Recruiting
Phase 2
Gruppo Oncologico del Nord-Ovest
Recruiting
Last update posted :
01/23/2025
Initiation :
07/23/2024
Primary completion :
08/01/2026
Completion :
04/01/2027
BRAF
|
Erbitux (cetuximab) • Braftovi (encorafenib)
Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer (NCT06776757)
Phase 1/2
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center
Cancer Hospital Chinese Academy of Medi...
Recruiting
Phase 1/2
Cancer Hospital Chinese Academy of Medical Scie...
Recruiting
Last update posted :
01/15/2025
Initiation :
12/25/2023
Primary completion :
06/25/2025
Completion :
12/25/2025
BRAF
|
Erbitux (cetuximab) • 5-fluorouracil • Tyvyt (sintilimab) • oxaliplatin • irinotecan • leucovorin calcium
S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery (SWOG S1613) (NCT03365882)
Phase 2
SWOG Cancer Research Network
SWOG Cancer Research Network
Active, not recruiting
Phase 2
SWOG Cancer Research Network
Active, not recruiting
Last update posted :
01/14/2025
Initiation :
11/27/2017
Primary completion :
11/01/2022
Completion :
11/30/2025
HER-2 • KRAS • BRAF • NRAS
|
BRAF V600E • HER-2 amplification • BRAF V600
|
Herceptin (trastuzumab) • Erbitux (cetuximab) • Perjeta (pertuzumab) • irinotecan • Trazimera (trastuzumab-qyyp)
Irinotecan Liposomes Combined With Cetuximab + Vermofenib in First-line Failure of Advanced Colorectal Cancer (VICPROIRI) (NCT06763029)
Phase 2
Fudan University
Fudan University
Not yet recruiting
Phase 2
Fudan University
Not yet recruiting
Last update posted :
01/13/2025
Initiation :
01/02/2025
Primary completion :
12/31/2026
Completion :
12/31/2026
BRAF
|
Erbitux (cetuximab)
Preoperative Tislelizumab -Cetuximab - Chemotherapy Followed by Salvage Surgery and Adjuvant Tislelizumab -Cetuximab for Resectable, Locally Recurrent Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC) (NCT06728618)
Phase 2
Shanghai Zhongshan Hospital
Shanghai Zhongshan Hospital
Not yet recruiting
Phase 2
Shanghai Zhongshan Hospital
Not yet recruiting
Last update posted :
12/11/2024
Initiation :
12/01/2024
Primary completion :
05/01/2026
Completion :
03/01/2028
TMB • MSI
|
PD-L1 expression
|
Erbitux (cetuximab) • cisplatin • Tevimbra (tislelizumab-jsgr) • albumin-bound paclitaxel
Phase I Trial of Adagrasib (MRTX849) in Combination with Cetuximab and Irinotecan in Patients with Colorectal Cancer (NCT05722327)
Phase 1
M.D. Anderson Cancer Center
M.D. Anderson Cancer Center
Recruiting
Phase 1
M.D. Anderson Cancer Center
Recruiting
Last update posted :
12/09/2024
Initiation :
12/06/2023
Primary completion :
09/30/2025
Completion :
09/30/2027
KRAS • UGT1A1
|
KRAS mutation • KRAS G12C • KRAS G12
|
Erbitux (cetuximab) • irinotecan • Krazati (adagrasib)
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