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    EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults (STRIvE-01) (NCT03618381)
    Phase 1
    Seattle Children's Hospital
    Recruiting
    Last update posted :
    04/09/2024
    Initiation :
    06/18/2019
    Primary completion :
    06/01/2025
    Completion :
    06/01/2040
    EGFR
    |
    EGFR expression
    |
    EGFR806-specific CAR T-cell therapy • SCRI-CARB7H3(s)x19 • SCRI-huCAR19v1
    EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors (NCT03638167)
    Phase 1
    Seattle Children's Hospital
    Active, not recruiting
    Last update posted :
    10/27/2023
    Initiation :
    03/19/2019
    Primary completion :
    03/01/2025
    Completion :
    03/01/2040
    EGFR
    |
    EGFR expression • EGFR positive
    |
    EGFR806-specific CAR T-cell therapy
    Study of CXCR5 Modified EGFR Targeted CAR-T Cells for Advanced NSCLC (NCT05060796)
    Phase 1
    Second Affiliated Hospital of Guangzhou Medical...
    Recruiting
    Last update posted :
    02/28/2023
    Initiation :
    09/01/2019
    Primary completion :
    11/01/2024
    Completion :
    11/01/2034
    EGFR • CXCL13
    |
    EGFR expression
    EGFR/B7H3 CAR-T on Lung Cancer and Triple Negative Breast Cancer (NCT05341492)
    Phase 1
    Second Affiliated Hospital of Guangzhou Medical...
    Recruiting
    Last update posted :
    02/28/2023
    Initiation :
    05/01/2022
    Primary completion :
    05/01/2025
    Completion :
    05/01/2025
    EGFR • CD276
    |
    EGFR expression • CD276 expression
    |
    Undisclosed EGFR/B7H3 CAR-T
    GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T Cells Against Cancers (NCT03198052)
    Phase 1
    Second Affiliated Hospital of Guangzhou Medical...
    Recruiting
    Last update posted :
    02/14/2023
    Initiation :
    07/01/2017
    Primary completion :
    08/01/2024
    Completion :
    08/01/2026
    EGFR • HER-2 • CLDN18 • AXL • MSLN • MUC1 • CD276 • GPC3 • GUCY2C • PSCA
    |
    MSLN expression • EGFR positive • GPC3 expression
    |
    GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T cells
    Study of CXCR5 Modified EGFE Chimeric Antigen Receptor Autologous T Cells in EGFR- Positive Patients With Advanced Non-small Cell Lung Cancer (NCT04153799)
    Phase 1
    Sun Yat-sen University
    Recruiting
    Last update posted :
    05/12/2020
    Initiation :
    11/01/2019
    Primary completion :
    12/01/2021
    Completion :
    12/01/2022
    EGFR • CXCL13
    |
    EGFR expression
    |
    CXCR5 Modified EGFR Targeted CAR-T Cells
    EGFR-IL12-CART Cells for Patients With Metastatic Colorectal Cancer (EGFRCART) (NCT03542799)
    Phase 1/2
    Shenzhen Second People's Hospital
    Unknown status
    Last update posted :
    05/31/2018
    Initiation :
    05/22/2018
    Primary completion :
    05/23/2020
    Completion :
    05/23/2021
    EGFR
    |
    EGFR positive
    |
    EGFR IL12 CART cells
    EGFR CART Cells for Patients With Metastatic Colorectal Cancer (NCT03152435)
    Phase 1/2
    Shenzhen Second People's Hospital
    Unknown status
    Last update posted :
    08/16/2017
    Initiation :
    06/15/2017
    Primary completion :
    09/01/2019
    Completion :
    12/01/2019
    EGFR
    |
    EGFR positive
    CTLA-4 and PD-1 Antibodies Expressing EGFR-CAR-T Cells for EGFR Positive Advanced Solid Tumor (NCT03182816)
    Phase 1/2
    Shanghai Cell Therapy Research Institute
    Unknown status
    Last update posted :
    06/09/2017
    Initiation :
    06/07/2017
    Primary completion :
    01/20/2019
    Completion :
    04/20/2019
    EGFR
    |
    cyclophosphamide
    Treatment of Chemotherapy Refractory EGFR(Epidermal Growth Factor Receptor) Positive Advanced Solid Tumors (CART-EGFR) (NCT01869166)
    Phase 1/2
    Chinese PLA General Hospital
    Unknown status
    Last update posted :
    09/29/2015
    Initiation :
    05/01/2013
    Primary completion :
    12/01/2016
    Completion :
    12/01/2017
    EGFR
    |
    EGFR positive
    |
    CART-EGFR