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    Evaluation, in Humans, of the Correlation Between Hepatotoxicity, Neurotoxicity Induced by Oxaliplatin, and Blood Levels of HMGB1 (HEPATOXALI) (NCT06649474)
    Phase N/A
    University Hospital, Clermont-Ferrand
    Recruiting
    Last update posted :
    10/18/2024
    Initiation :
    09/06/2024
    Primary completion :
    06/30/2028
    Completion :
    06/30/2028
    HMGB1
    |
    oxaliplatin
    A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 (KEYNOTE-A10) (NCT03058289)
    Phase 1/2
    Intensity Therapeutics, Inc.
    Completed
    Last update posted :
    08/13/2024
    Initiation :
    02/09/2017
    Primary completion :
    02/22/2023
    Completion :
    02/22/2023
    MSI • CD8 • PD-1 • IFNG • IL6 • LAG3 • TNFA • CTLA4 • CD4 • IL2 • ICOS • IL10 • FOXP3 • IL1B
    |
    Keytruda (pembrolizumab) • Yervoy (ipilimumab) • cisplatin/vinblastine/SHAO-FA (INT230-6)
    LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus Lapatinib (NCT00680901)
    Phase 3
    Novartis Pharmaceuticals
    Active, not recruiting
    Last update posted :
    06/13/2024
    Initiation :
    06/04/2008
    Primary completion :
    09/24/2012
    Completion :
    01/22/2025
    HER-2
    |
    HER-2 positive
    |
    lapatinib • capecitabine • oxaliplatin
    Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC (NCT06002789)
    Phase 2
    Sixth Affiliated Hospital, Sun Yat-sen University
    Recruiting
    Last update posted :
    02/07/2024
    Initiation :
    05/01/2022
    Primary completion :
    09/01/2024
    Completion :
    09/01/2026
    MSI • MSH6 • MSH2
    |
    MSI-H/dMMR
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium
    METIMMOX-2: Metastatic pMMR/MSS Colorectal Cancer - Shaping Anti-Tumor Immunity by Oxaliplatin (NCT05504252)
    Phase 2
    University Hospital, Akershus
    Recruiting
    Last update posted :
    01/30/2024
    Initiation :
    10/05/2022
    Primary completion :
    09/30/2025
    Completion :
    12/30/2027
    CRP
    |
    Opdivo (nivolumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium
    METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin (NCT03388190)
    Phase 2
    University Hospital, Akershus
    Active, not recruiting
    Last update posted :
    01/30/2024
    Initiation :
    05/29/2018
    Primary completion :
    06/30/2024
    Completion :
    06/30/2025
    PTEN • CRP
    |
    Opdivo (nivolumab) • 5-fluorouracil • oxaliplatin • leucovorin calcium
    Intra-hepatic Chemotherapy in Patients With Liver Metastases From Breast Cancer and Limited Extrahepatic Disease (NCT01387295)
    Phase 2
    Dorte Nielsen
    Completed
    Last update posted :
    12/11/2023
    Initiation :
    04/01/2010
    Primary completion :
    05/01/2017
    Completion :
    09/01/2017
    HER-2
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • capecitabine • oxaliplatin
    Oxaliplatin - Induced Peripheral Neuropathy in Patients With Gastrointestinal Tract Cancer (NCT02428101)
    Phase N/A
    Ain Shams University
    Enrolling by invitation
    Last update posted :
    11/28/2023
    Initiation :
    11/01/2014
    Primary completion :
    02/01/2024
    Completion :
    04/01/2024
    ABCG2
    |
    oxaliplatin
    Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia (TUD-APOLLO-064) (NCT02688140)
    Phase 3
    Technische Universität Dresden
    Active, not recruiting
    Last update posted :
    11/02/2023
    Initiation :
    06/01/2016
    Primary completion :
    01/01/2025
    Completion :
    01/01/2025
    PML
    |
    PML-RARA fusion • Chr t(15;17) • Chr t(15;17)/PML-RARA fusion
    |
    cytarabine • idarubicin hydrochloride • mitoxantrone • arsenic trioxide • mercaptopurine
    Rectal Artery Infusion Chemotherapy Combined With Anti-PD1 Antibody for MSS LARC (RAIC) (NCT05307198)
    Phase 2
    Second Affiliated Hospital, School of Medicine,...
    Recruiting
    Last update posted :
    10/09/2023
    Initiation :
    05/11/2022
    Primary completion :
    04/25/2024
    Completion :
    04/25/2025
    FLT3LG
    |
    Tyvyt (sintilimab) • capecitabine • oxaliplatin
    IRinotecan and Oxaliplatin for Colon Cancer in Adjuvant Setting (IROCAS) (NCT02967289)
    Phase 3
    UNICANCER
    Active, not recruiting
    Last update posted :
    09/04/2023
    Initiation :
    03/27/2017
    Primary completion :
    06/01/2024
    Completion :
    06/01/2027
    CEACAM5
    |
    5-fluorouracil • oxaliplatin • irinotecan
    Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver (OSCAR) (NCT02885753)
    Phase 3
    Federation Francophone de Cancerologie Digestive
    Recruiting
    Last update posted :
    08/17/2023
    Initiation :
    12/01/2016
    Primary completion :
    09/01/2025
    Completion :
    09/01/2027
    KRAS • NRAS • RAS
    |
    KRAS mutation • NRAS mutation • RAS mutation • KRAS exon 2 mutation
    |
    Avastin (bevacizumab) • 5-fluorouracil • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium
    Oxaliplatin Adjuvant Chemotherapy After Curative Resection of Primary Colon Cancer (OCEAN) (NCT04416490)
    Phase N/A
    Boryung Pharmaceutical Co., Ltd
    Recruiting
    Last update posted :
    07/28/2023
    Initiation :
    03/25/2020
    Primary completion :
    03/31/2026
    Completion :
    03/31/2026
    BRAF
    |
    oxaliplatin
    Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE) (NCT05646511)
    Phase 3
    National Cancer Center Hospital East
    Recruiting
    Last update posted :
    05/31/2023
    Initiation :
    11/21/2022
    Primary completion :
    12/31/2029
    Completion :
    12/31/2030
    UGT1A1
    |
    UGT1A1*1*1 • UGT1A1 wild-type
    |
    capecitabine • oxaliplatin • irinotecan
    S0919 Idarubicin, Cytarabine, and Pravastatin in Treating Patients With Relapsed Acute Myeloid Leukemia (NCT00840177)
    Phase 2
    SWOG Cancer Research Network
    Completed
    Last update posted :
    05/03/2023
    Initiation :
    12/10/2009
    Primary completion :
    12/01/2018
    Completion :
    10/21/2021
    CD4
    |
    cytarabine • idarubicin hydrochloride
    The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy (NCT05624138)
    Phase 3
    Tanta University
    Recruiting
    Last update posted :
    04/12/2023
    Initiation :
    11/09/2022
    Primary completion :
    11/01/2023
    Completion :
    11/01/2024
    IL6
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium
    CAPEOX vs Observation in Colorectal Cancer Patients With Positive MRD (CAREME) (NCT05699746)
    Phase 3
    Zhejiang University
    Not yet recruiting
    Last update posted :
    01/26/2023
    Initiation :
    03/01/2023
    Primary completion :
    09/01/2026
    Completion :
    12/01/2026
    MSH6 • MSH2
    |
    capecitabine • oxaliplatin
    HAIC With One-day FOLFOX vs. HAIC With Two-day FOLFOX for Unresectable HCC: a Non-inferiority Study (NCT05476432)
    Phase 3
    Sun Yat-sen University
    Recruiting
    Last update posted :
    12/09/2022
    Initiation :
    07/26/2022
    Primary completion :
    07/01/2025
    Completion :
    10/01/2026
    TYMS
    |
    5-fluorouracil • oxaliplatin • leucovorin calcium
    Comparative Clinical Study Evaluating the Possible Efficacy of Duloxetine, Gabapentin and Lacosamide on Oxaliplatin-Induced Peripheral Neuropathy in Cancer Patients (NCT05510856)
    Phase 4
    Tanta University
    Recruiting
    Last update posted :
    10/20/2022
    Initiation :
    09/01/2022
    Primary completion :
    09/01/2023
    Completion :
    09/01/2024
    HMOX1 • NEFL
    |
    oxaliplatin
    A Screening Study Targeting Tumor-specific Antigens (NCT05158621)
    Phase N/A
    Gritstone bio, Inc.
    Completed
    Last update posted :
    10/18/2022
    Initiation :
    12/14/2021
    Primary completion :
    08/15/2022
    Completion :
    08/15/2022
    KRAS
    |
    oxaliplatin
    Anti-PD-1 and CapOx for the First-line Treatment of dMMR Esophagogastric Cancer (AuspiCiOus) (NCT05177133)
    Phase 2
    Academisch Medisch Centrum - Universiteit van A...
    Recruiting
    Last update posted :
    09/16/2022
    Initiation :
    11/05/2021
    Primary completion :
    05/01/2025
    Completion :
    11/04/2029
    HER-2 • IFNG • MLH1 • MSH6 • MSH2
    |
    HER-2 positive • MSI-H/dMMR • HER-2 negative • IFNG expression
    |
    capecitabine • oxaliplatin • Zynyz (retifanlimab-dlwr)
    the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin (NCT05494320)
    Phase N/A
    Ain Shams University
    Recruiting
    Last update posted :
    08/09/2022
    Initiation :
    08/15/2021
    Primary completion :
    08/05/2022
    Completion :
    12/31/2022
    ABCC2
    |
    5-fluorouracil • oxaliplatin
    INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast Cancer (NCT04781725)
    Phase 2
    Ottawa Hospital Research Institute
    Recruiting
    Last update posted :
    11/17/2021
    Initiation :
    03/25/2021
    Primary completion :
    03/01/2022
    Completion :
    03/01/2023
    CD8 • CD4
    |
    cisplatin • cisplatin/vinblastine/SHAO-FA (INT230-6)
    Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia (NCT02144675)
    Phase 2
    Rutgers, The State University of New Jersey
    Completed
    Last update posted :
    08/24/2021
    Initiation :
    01/01/2009
    Primary completion :
    04/26/2016
    Completion :
    04/26/2016
    FLT3 • NPM1
    |
    NPM1 mutation
    |
    cytarabine • idarubicin hydrochloride
    PD-1 Antibody + XELOX in 1st Line Serum A-fetoprotein (AFP)-Elevated Gastric or Gastroesophageal Junction Adenocarcinoma (NCT04098796)
    Phase 2
    China Medical University, China
    Recruiting
    Last update posted :
    04/14/2021
    Initiation :
    10/01/2019
    Primary completion :
    09/30/2021
    Completion :
    09/30/2021
    PD-L1 • AFP
    |
    PD-L1 expression
    |
    Tyvyt (sintilimab) • capecitabine • oxaliplatin
    PETHEMA-LMA10: Treatment of Acute Myeloblastic Leukemia (AML) in Patients Less Than or Equal to 65 Years (NCT01296178)
    Phase N/A
    PETHEMA Foundation
    Recruiting
    Last update posted :
    03/23/2021
    Initiation :
    12/01/2010
    Primary completion :
    12/01/2021
    Completion :
    12/01/2021
    PML
    |
    cytarabine • idarubicin hydrochloride
    Short-course Versus Long-course Pre-operative Chemotherapy With mFOLFIRINOX or PAXG (CASSANDRA TRIAL) (NCT04793932)
    Phase 2
    Associazione Italiana per lo Studio del Pancreas
    Recruiting
    Last update posted :
    03/11/2021
    Initiation :
    11/03/2020
    Primary completion :
    11/01/2021
    Completion :
    11/01/2023
    CA 19-9
    |
    cisplatin • paclitaxel • capecitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan
    Adoptive Transfer of Haplo-identical DLI for AML and MDS (NCT02046122)
    Phase 1/2
    Duke University
    Completed
    Last update posted :
    12/03/2020
    Initiation :
    07/01/2014
    Primary completion :
    06/15/2017
    Completion :
    07/31/2019
    FLT3
    |
    Chr del(5q)
    |
    cytarabine • idarubicin hydrochloride
    "AIDA" Protocol (LAP 0493) (NCT01064557)
    Phase N/A
    Gruppo Italiano Malattie EMatologiche dell'Adulto
    Recruiting
    Last update posted :
    10/14/2020
    Initiation :
    10/01/1993
    Primary completion :
    12/01/2020
    Completion :
    12/01/2020
    PML
    |
    idarubicin hydrochloride
    Intra-hepatic Chemotherapy in Patient With Non-resectable Liver Metastases From Breast Cancer (NCT01387373)
    Phase 2
    Dorte Nielsen
    Completed
    Last update posted :
    10/05/2020
    Initiation :
    04/01/2010
    Primary completion :
    05/01/2017
    Completion :
    09/01/2017
    HER-2
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • capecitabine • oxaliplatin
    Exploratory Study Of The ERCC-1 Gene (NCT00846482)
    Phase N/A
    Albert Einstein College of Medicine
    Completed
    Last update posted :
    09/16/2020
    Initiation :
    02/01/2008
    Primary completion :
    12/01/2018
    Completion :
    12/01/2018
    ERCC1
    |
    oxaliplatin
    Robotic Total Gastrectomy for Locally Advanced Proximal Gastric Cancer (NCT03524287)
    Phase N/A
    Fujian Medical University
    Completed
    Last update posted :
    09/09/2020
    Initiation :
    03/01/2018
    Primary completion :
    02/10/2020
    Completion :
    03/10/2020
    CRP
    |
    oxaliplatin
    Preoperative Folfirinox, Radiation Therapy for Resectable Adenocarcinoma of the Pancreas (NCT01560949)
    Phase 2
    M.D. Anderson Cancer Center
    Completed
    Last update posted :
    08/10/2020
    Initiation :
    06/14/2012
    Primary completion :
    02/20/2019
    Completion :
    02/20/2019
    SMAD4
    |
    SMAD4 positive
    |
    gemcitabine • 5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSI-H Locally Advanced Rectal Cancer (NCT04411524)
    Phase 2
    Fudan University
    Not yet recruiting
    Last update posted :
    06/02/2020
    Initiation :
    07/01/2020
    Primary completion :
    04/30/2022
    Completion :
    12/31/2022
    MSI • UGT1A1
    |
    MSI-H/dMMR • UGT1A1*28 • UGT1A1*1*1
    |
    capecitabine • oxaliplatin • irinotecan
    The Combination of Immunotherapy and Neoadjuvant Chemoradiotherapy in MSS Locally Advanced Rectal Cancer (NCT04411537)
    Phase 2
    Fudan University
    Not yet recruiting
    Last update posted :
    06/02/2020
    Initiation :
    07/01/2020
    Primary completion :
    04/30/2022
    Completion :
    12/31/2022
    MSI • UGT1A1
    |
    UGT1A1*28 • UGT1A1*1*1
    |
    capecitabine • oxaliplatin • irinotecan
    Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer (NCT02043288)
    Phase 3
    Orient Europharma Co., Ltd.
    Completed
    Last update posted :
    04/15/2020
    Initiation :
    01/01/2014
    Primary completion :
    12/01/2019
    Completion :
    12/01/2019
    CA 19-9
    |
    cisplatin • gemcitabine • Nanoplatin (demplatin pegraglumer)
    Efficacy of Postoperative Adjuvant Chemotherapy for Stage II Colon Cancer With High Risk Factors(EPAC1) (NCT03199989)
    Phase 3
    Peking University Cancer Hospital & Institute
    Recruiting
    Last update posted :
    03/06/2020
    Initiation :
    06/01/2017
    Primary completion :
    07/31/2021
    Completion :
    07/31/2024
    MSI
    |
    capecitabine • oxaliplatin
    Combination Therapy With NC-6004 and Gemcitabine in Advanced Solid Tumors or Non-Small Cell Lung, Biliary and Bladder Cancer (NCT02240238)
    Phase 1b/2
    NanoCarrier Co., Ltd.
    Completed
    Last update posted :
    02/28/2020
    Initiation :
    05/01/2014
    Primary completion :
    05/06/2019
    Completion :
    05/06/2019
    EGFR • ALK
    |
    EGFR mutation • ALK fusion
    |
    cisplatin • gemcitabine • Nanoplatin (demplatin pegraglumer)
    Study on Laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection for Advanced Gastric Cancer (CLASS-04) (NCT02845986)
    Phase 2
    Fujian Medical University
    Unknown status
    Last update posted :
    02/05/2020
    Initiation :
    09/01/2016
    Primary completion :
    10/12/2017
    Completion :
    10/12/2020
    CRP
    |
    oxaliplatin
    Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery (NCT02896907)
    Phase 1
    Sidney Kimmel Cancer Center at Thomas Jefferson...
    Completed
    Last update posted :
    01/18/2020
    Initiation :
    10/18/2016
    Primary completion :
    03/22/2018
    Completion :
    03/01/2019
    G6PD
    |
    5-fluorouracil • oxaliplatin • irinotecan • leucovorin calcium
    Phase II Study Of Neoadjuvant Chemotherapy In Borderline Resectable Pancreatic Adenocarcinoma (NCT00728000)
    Phase 2
    University of Cincinnati
    Withdrawn
    Last update posted :
    11/25/2019
    Initiation :
    08/01/2008
    Primary completion :
    08/01/2009
    Completion :
    08/01/2010
    ERCC1 • ERCC2 • DCK
    |
    erlotinib • gemcitabine • oxaliplatin
    BP-C1 in Metastatic Breast Cancer Patients (NCT01861509)
    Phase 1
    Meabco A/S
    Completed
    Last update posted :
    10/07/2019
    Initiation :
    01/19/2014
    Primary completion :
    01/20/2016
    Completion :
    01/20/2016
    IFNG • IL6 • TNFA • CXCL8 • IL2 • IL10 • IL1B • IL21 • IL4
    |
    BP-C1