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    DRUG:

    cytarabine

    i
    Other names: HiDAC, LDAC
    Company:
    Generic mfg.
    Drug class:
    DNA synthesis inhibitor, DNA-directed DNAP inhibitor
    Related drugs:
    Apply
    Testing Oral Decitabine and Cedazuridine (ASTX727) in Combination With Venetoclax for Higher-Risk Acute Myeloid Leukemia Patients (NCI-2021-02246) (NCT04817241)
    Phase 1/2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    11/30/2023
    Initiation :
    02/10/2022
    Primary completion :
    08/01/2024
    Completion :
    08/01/2024
    BCL2
    |
    Venclexta (venetoclax) • cytarabine • daunorubicin • Inqovi (decitabine/cedazuridine) • Starasid (cytarabine ocfosfate)
    Standard Chemotherapy With or Without Nelarabine or Rituximab in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia (UKALL14) (NCT01085617)
    Phase 3
    University College, London
    Active, not recruiting
    Last update posted :
    11/29/2023
    Initiation :
    12/01/2010
    Primary completion :
    12/01/2023
    Completion :
    07/01/2024
    ABL1 • BCR • MYC
    |
    MYC translocation • Chr t(4;11)(q21;q23)
    |
    Rituxan (rituximab) • imatinib • cytarabine • cyclophosphamide • etoposide IV • vincristine • daunorubicin • melphalan • Oncaspar liquid (pegaspargase) • fludarabine IV • nelarabine • mercaptopurine • Kepivance (palifermin)
    Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma (NCT01979536)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/29/2023
    Initiation :
    11/13/2013
    Primary completion :
    03/31/2021
    Completion :
    09/22/2024
    ALK
    |
    ALK positive
    |
    Xalkori (crizotinib) • cytarabine • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • Adcetris (brentuximab vedotin) • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate)
    A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (NCT04501614)
    Phase 1/2
    Takeda
    Recruiting
    Last update posted :
    11/29/2023
    Initiation :
    02/24/2021
    Primary completion :
    02/27/2025
    Completion :
    08/27/2027
    ABL1 • BCR • IGH • PDGFRB • CSF1R
    |
    BCR-ABL1 fusion • BCR-ABL1 T315I • ABL1 T315I • BCR-ABL1 mutation
    |
    cytarabine • Iclusig (ponatinib) • cyclophosphamide
    Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation (NCT02356159)
    Phase 1/2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    11/29/2023
    Initiation :
    09/24/2015
    Primary completion :
    01/01/2024
    Completion :
    01/01/2024
    FLT3 • ABL1 • BCR • ASXL1 • CD34 • HLA-B • HLA-C
    |
    Chr t(9;11)
    |
    Rituxan (rituximab) • cytarabine • doxorubicin hydrochloride • cyclophosphamide • sirolimus • fludarabine IV • Kepivance (palifermin)
    Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia (NCT01424982)
    Phase 2
    M.D. Anderson Cancer Center
    Active, not recruiting
    Last update posted :
    11/29/2023
    Initiation :
    10/05/2011
    Primary completion :
    10/31/2025
    Completion :
    10/31/2025
    ABL1 • BCR
    |
    Rituxan (rituximab) • cytarabine • Iclusig (ponatinib) • doxorubicin hydrochloride • cyclophosphamide • methotrexate • vincristine • daunorubicin • Starasid (cytarabine ocfosfate)
    Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia (NCT03571321)
    Phase 1
    University of Chicago
    Recruiting
    Last update posted :
    11/29/2023
    Initiation :
    05/28/2019
    Primary completion :
    09/01/2026
    Completion :
    09/05/2027
    JAK2 • CRLF2 • IL7R • SH2B3
    |
    CRLF2 rearrangement • JAK2 mutation • IL7R mutation • JAK2 rearrangement • SH2B3 deletion
    |
    Rituxan (rituximab) • cytarabine • doxorubicin hydrochloride • Jakafi (ruxolitinib) • cyclophosphamide • vincristine • Oncaspar liquid (pegaspargase) • mercaptopurine • thioguanine
    Intensive Conditioning With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Myeloid Malignancies With Extramedullary Involvement (NCT06111612)
    Phase N/A
    Shanghai General Hospital, Shanghai Jiao Tong U...
    Not yet recruiting
    Last update posted :
    11/28/2023
    Initiation :
    01/01/2024
    Primary completion :
    01/01/2026
    Completion :
    01/01/2027
    HLA-DRB1 • HLA-B • HLA-C
    |
    cytarabine • fludarabine IV • thiotepa • busulfan
    Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms (NCT06034470)
    Phase 1
    Fred Hutchinson Cancer Center
    Not yet recruiting
    Last update posted :
    11/28/2023
    Initiation :
    02/01/2024
    Primary completion :
    12/31/2026
    Completion :
    12/31/2027
    IL3RA
    |
    CD123 expression • Chr t(15;17) • IL3RA expression
    |
    cytarabine • idarubicin hydrochloride • fludarabine IV • pivekimab sunirine (IMGN632) • Starasid (cytarabine ocfosfate)
    TEAM (Thiotepa, Etoposide, Cytosar, Melphalan ) for AutoSCT in Lymphoma (NCT03346096)
    Phase 2
    Sheba Medical Center
    Active, not recruiting
    Last update posted :
    11/28/2023
    Initiation :
    10/09/2018
    Primary completion :
    04/01/2024
    Completion :
    04/01/2024
    CD34
    |
    cytarabine • etoposide IV • melphalan • thiotepa
    Venetoclax Plus RIC Regimen Allo-HSCT for Elderly Patients With High-risk Myeloid Malignancies (NCT05583175)
    Phase 2
    Xianmin Song, MD
    Recruiting
    Last update posted :
    11/28/2023
    Initiation :
    11/01/2022
    Primary completion :
    11/01/2024
    Completion :
    11/01/2024
    HLA-DRB1
    |
    Venclexta (venetoclax) • cytarabine
    Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome (NCT02521493)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    11/24/2023
    Initiation :
    12/23/2015
    Primary completion :
    06/30/2024
    Completion :
    06/30/2024
    GATA1
    |
    cytarabine • etoposide IV • daunorubicin • mitoxantrone • mercaptopurine delayed release (DR6MP) • mercaptopurine • Rylaze (recombinant Erwinia asparaginase) • thioguanine • Erwinase (erwinia L-asparaginase) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate)
    Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia (NCT02339740)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    11/22/2023
    Initiation :
    07/21/2015
    Primary completion :
    10/31/2020
    Completion :
    09/22/2024
    FLT3 • RARA • PML
    |
    FLT3 mutation • FLT3 wild-type
    |
    cytarabine • mitoxantrone • idarubicin hydrochloride • Vesanoid (tretinoin) • arsenic trioxide • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate)
    Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia (NCT00792948)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/22/2023
    Initiation :
    09/01/2009
    Primary completion :
    06/01/2016
    Completion :
    01/06/2024
    ABL1 • BCR • CD22 • CD5 • CD79A • CD7 • MME • ANPEP • MPO
    |
    dasatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • methotrexate • vincristine • sirolimus • leucovorin calcium • Hemady (dexamethasone tablets) • Neupogen (filgrastim) • Starasid (cytarabine ocfosfate)
    A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation (ADMIRAL) (NCT02421939)
    Phase 3
    Astellas Pharma Global Development, Inc.
    Active, not recruiting
    Last update posted :
    11/22/2023
    Initiation :
    10/20/2015
    Primary completion :
    09/17/2018
    Completion :
    07/31/2024
    FLT3
    |
    FLT3-ITD mutation • FLT3 mutation • FLT3 D835 • FLT3 I836
    |
    cytarabine • azacitidine • Xospata (gilteritinib) • etoposide IV • mitoxantrone • idarubicin hydrochloride • fludarabine IV
    Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma (AALL1231) (NCT02112916)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/21/2023
    Initiation :
    10/04/2014
    Primary completion :
    03/31/2020
    Completion :
    09/22/2024
    CD20 • CD8 • CD22 • CD34 • CD5 • CD7 • CD2 • MPO
    |
    CD22 expression
    |
    cytarabine • bortezomib • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate)
    Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (AALL1631) (NCT03007147)
    Phase 3
    Children's Oncology Group
    Recruiting
    Last update posted :
    11/21/2023
    Initiation :
    08/08/2017
    Primary completion :
    09/30/2027
    Completion :
    09/30/2027
    ABL1 • BCR • PDGFRA • PDGFRB • IKZF1 • CSF1R
    |
    BCR-ABL1 fusion • ABL1 deletion
    |
    imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Hemady (dexamethasone tablets) • Neupogen (filgrastim) • Starasid (cytarabine ocfosfate) • dexrazoxane
    Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma (AALL0434) (NCT00408005)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/21/2023
    Initiation :
    01/22/2007
    Primary completion :
    09/30/2017
    CD20 • CD8 • CD22 • CD34 • CD5 • CD7 • CD2 • MPO
    |
    CD22 expression
    |
    cytarabine • doxorubicin hydrochloride • cyclophosphamide • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • nelarabine • mercaptopurine • thioguanine • Hemady (dexamethasone tablets) • Kidrolase (L-asparaginase) • Leunase (L-asparaginase) • Spectrila (asparaginase Escherichia coli) • Starasid (cytarabine ocfosfate) • dexamethasone injection
    Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia (AALL1621) (NCT02981628)
    Phase 2
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    11/21/2023
    Initiation :
    06/19/2017
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    KMT2A • CD22
    |
    MLL rearrangement • CD22 expression
    |
    cytarabine • cyclophosphamide • methotrexate • vincristine • Besponsa (inotuzumab ozogamicin) • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • Starasid (cytarabine ocfosfate)
    Quizartinib With Standard of Care Chemotherapy and as Continuation Therapy in Patients With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia (AML) (QuANTUM-First) (NCT02668653)
    Phase 3
    Daiichi Sankyo, Inc.
    Completed
    Last update posted :
    11/20/2023
    Initiation :
    09/01/2016
    Primary completion :
    08/13/2021
    Completion :
    06/16/2023
    FLT3
    |
    FLT3-ITD mutation
    |
    cytarabine • Vanflyta (quizartinib) • daunorubicin • idarubicin hydrochloride
    Venetoclax in Addition to Sequential Conditioning With Fludarabine / Amsacrine / Ara-C (FLAMSA) + Treosulfan for Allogeneic Blood Stem Cell Transplantation in Patients With MDS, CMML or sAML (NCT05807932)
    Phase 1/2
    Heinrich-Heine University, Duesseldorf
    Recruiting
    Last update posted :
    11/17/2023
    Initiation :
    06/26/2023
    Primary completion :
    01/31/2026
    Completion :
    01/30/2028
    KRAS • TP53 • NRAS • IDH1 • IDH2 • NF1 • RUNX1 • KMT2A • PTPN11 • NUP214 • DEK • RIT1
    |
    KRAS mutation • NRAS mutation • NF1 mutation • RAS mutation • CBL mutation
    |
    Venclexta (venetoclax) • cytarabine • fludarabine IV • Ovastat (treosulfan) • Amsidine (amsacrine)
    Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML) (NCT05183035)
    Phase 3
    LLS PedAL Initiative, LLC
    Recruiting
    Last update posted :
    11/17/2023
    Initiation :
    10/01/2022
    FLT3 • BCL2
    |
    FLT3-ITD mutation
    |
    Venclexta (venetoclax) • cytarabine • azacitidine • Mylotarg (gemtuzumab ozogamicin) • fludarabine IV
    Open-label Study of FT-2102 With or Without Azacitidine or Cytarabine in Patients With AML or MDS With an IDH1 Mutation (NCT02719574)
    Phase 1/2
    Forma Therapeutics, Inc.
    Active, not recruiting
    Last update posted :
    11/17/2023
    IDH1
    |
    IDH1 R132 • Chr t(15;17)
    |
    cytarabine • azacitidine • Rezlidhia (olutasidenib)
    Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) (NCI-MATCH) (NCT02465060)
    Phase 2
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/16/2023
    Initiation :
    08/17/2015
    Primary completion :
    12/31/2025
    Completion :
    12/31/2025
    MSI • CD4
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • Avastin (bevacizumab) • Herceptin (trastuzumab) • Lynparza (olaparib) • cisplatin • Mekinist (trametinib) • Xalkori (crizotinib) • Tagrisso (osimertinib) • Tecentriq (atezolizumab) • Gilotrif (afatinib) • Yervoy (ipilimumab) • dasatinib • Ibrance (palbociclib) • Tafinlar (dabrafenib) • carboplatin • Imfinzi (durvalumab) • Vitrakvi (larotrectinib) • Imbruvica (ibrutinib) • gemcitabine • paclitaxel • Rituxan (rituximab) • docetaxel • 5-fluorouracil • Sutent (sunitinib) • everolimus • Vectibix (panitumumab) • temozolomide • Koselugo (selumetinib) • Perjeta (pertuzumab) • cytarabine • Kadcyla (ado-trastuzumab emtansine) • bortezomib • doxorubicin hydrochloride • Talzenna (talazoparib) • capecitabine • Piqray (alpelisib) • enzalutamide capsule • azacitidine • Cabometyx (cabozantinib tablet) • Balversa (erdafitinib) • Gazyva (obinutuzumab) • Mektovi (binimetinib) • albumin-bound paclitaxel • cyclophosphamide • Imjudo (tremelimumab) • Cyramza (ramucirumab) • pemetrexed • fulvestrant • oxaliplatin • adavosertib (AZD1775) • etoposide IV • irinotecan • Xpovio (selinexor) • Conmana (icotinib) • Halaven (eribulin mesylate) • Pemazyre (pemigatinib) • Zarnestra (tipifarnib) • methotrexate • Truqap (capivasertib) • fexagratinib (ABSK091) • Aliqopa (copanlisib) • Ninlaro (ixazomib) • pegylated liposomal doxorubicin • epirubicin • ipatasertib (RG7440) • sapanisertib (CB-228) • Caprelsa (vandetanib) • vincristine • vinorelbine tartrate • Cometriq (cabozantinib capsule) • Tabrecta (capmatinib) • spartalizumab (PDR001) • taselisib (GDC-0032) • daunorubicin • ulixertinib (BVD-523) • mitoxantrone • Erivedge (vismodegib) • carmustine • bicalutamide • leucovorin calcium • bendamustine • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Zepzelca (lurbinectedin) • mitomycin • Jingzhuda (entinostat) • Recentin (cediranib) • Trazimera (trastuzumab-qyyp) • melphalan • GSK2636771 • Zirabev (bevacizumab-bvzr) • defactinib (VS-6063) • Zynyz (retifanlimab-dlwr) • fludarabine IV • goserelin acetate • Ostarine (enobosarm) • avadomide (CC-122) • vistusertib (AZD2014) • Myocet (non-pegylated liposomal doxorubicin) • vinblastine • Xofigo (radium Ra-223 dichloride) • lorvotuzumab mertansine (IMGN901) • Ampligen (rintatolimod) • E6201 • Fujovee (abivertinib) • Provenge (sipuleucel-T) • relatlimab (BMS-986016) • ABP 206 (nivolumab biosimilar) • Airuituo (bevacizumab biosimilar) • BCD-178 (pertuzumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • CC-90002 • EG1206A (pertuzumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • ImmuniCell (autologous γδ T lymphocytes) • Leukine (sargramostim) • TQB2440 (pertuzumab biosimilar) • Vasforda (bevacizumab biosimilar) • celecoxib oral • dexamethasone injection • ieramilimab (LAG525) • levoleucovorin calcium • sapitinib (AZD8931)
    Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia (NCT03263572)
    Phase 2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    11/16/2023
    Initiation :
    11/29/2017
    Primary completion :
    11/30/2024
    Completion :
    11/30/2024
    ABL1 • BCR
    |
    cytarabine • Iclusig (ponatinib) • Blincyto (blinatumomab) • methotrexate • Starasid (cytarabine ocfosfate)
    Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies (NCT05476770)
    Phase 1
    Therapeutic Advances in Childhood Leukemia Cons...
    Recruiting
    Last update posted :
    11/16/2023
    Initiation :
    11/11/2022
    Primary completion :
    11/11/2025
    Completion :
    11/11/2027
    IL3RA
    |
    CD123 expression
    |
    cytarabine • azacitidine • vincristine • fludarabine IV • Elzonris (tagraxofusp)
    DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia (NCT04752163)
    Phase 1/2
    M.D. Anderson Cancer Center
    Completed
    Last update posted :
    11/15/2023
    Initiation :
    03/25/2021
    Primary completion :
    11/08/2023
    Completion :
    11/08/2023
    FLT3 • NPM1
    |
    NPM1 mutation
    |
    Venclexta (venetoclax) • Rituxan (rituximab) • cytarabine • azacitidine • cyclophosphamide • methotrexate • vincristine • leucovorin calcium • DS-1594 • Riabni (rituximab-arrx) • Delito (rituximab biosimilar) • GB241 (rituximab biosimilar) • JHL1101 (rituximab biosimilar) • Neupogen (filgrastim) • Novex (rituximab biosimilar) • Starasid (cytarabine ocfosfate)
    An Efficacy and Safety Study of AG-221 (CC-90007) Versus Conventional Care Regimens in Older Subjects With Late Stage Acute Myeloid Leukemia Harboring an Isocitrate Dehydrogenase 2 Mutation (IDHENTIFY) (NCT02577406)
    Phase 3
    Celgene
    Active, not recruiting
    Last update posted :
    11/15/2023
    Initiation :
    12/30/2015
    Primary completion :
    03/17/2020
    Completion :
    12/31/2023
    IDH2 • UGT1A1
    |
    IDH2 mutation • UGT1A1*1*1 • UGT1A1 mutation
    |
    cytarabine • azacitidine • Idhifa (enasidenib) • hydroxyurea
    Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia (NCT03913559)
    Phase 2
    St. Jude Children's Research Hospital
    Recruiting
    Last update posted :
    11/14/2023
    Initiation :
    05/14/2019
    CD22
    |
    CD22 expression
    |
    cytarabine • methotrexate • Besponsa (inotuzumab ozogamicin) • methylprednisolone sodium succinate
    A Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combination With Either Chemotherapy or Venetoclax in Treatment of Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias or Solid Tumors (NCT04029688)
    Phase 1/2
    Hoffmann-La Roche
    Recruiting
    Last update posted :
    11/13/2023
    Initiation :
    01/27/2020
    Primary completion :
    12/30/2025
    Completion :
    12/30/2025
    TP53
    |
    TP53 wild-type
    |
    Venclexta (venetoclax) • cytarabine • cyclophosphamide • topotecan • idasanutlin (RG7388) • fludarabine IV
    A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD Relapse/Refractory (R/R) AML (AGORA-1) (NCT05199051)
    Phase 2
    Centre Antoine Lacassagne
    Recruiting
    Last update posted :
    11/10/2023
    Initiation :
    06/03/2023
    Primary completion :
    03/15/2027
    Completion :
    03/15/2027
    FLT3 • CD33
    |
    FLT3-ITD mutation • FLT3-TKD mutation • CD33 positive
    |
    cytarabine • Xospata (gilteritinib) • Mylotarg (gemtuzumab ozogamicin)
    Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome (NCT03092674)
    Phase 2/3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/10/2023
    Initiation :
    02/02/2018
    Primary completion :
    08/01/2023
    Completion :
    10/29/2024
    FLT3
    |
    Opdivo (nivolumab) • cytarabine • azacitidine • Rydapt (midostaurin) • decitabine • ABP 206 (nivolumab biosimilar) • Starasid (cytarabine ocfosfate)
    A Study of JNJ-75276617 in Combination With Acute Myeloid Leukemia (AML) Directed Therapies (NCT05453903)
    Phase 1b
    Janssen Research & Development, LLC
    Recruiting
    Last update posted :
    11/09/2023
    Initiation :
    10/04/2022
    Primary completion :
    05/15/2024
    Completion :
    01/02/2026
    NPM1 • KMT2A
    |
    Venclexta (venetoclax) • cytarabine • azacitidine • daunorubicin • idarubicin hydrochloride • JNJ-6617
    A Study Comparing the Combination of Dasatinib and Chemotherapy Treatment With or Without Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or Philadelphia Chromosome-Like (Ph-Like) ABL-Class B-Cell Acute Lymphoblastic Leukemia (B-ALL) (NCT06124157)
    Phase 3
    National Cancer Institute (NCI)
    Not yet recruiting
    Last update posted :
    11/09/2023
    Initiation :
    01/22/2024
    Primary completion :
    12/01/2030
    Completion :
    12/01/2030
    ABL1 • KIT • PDGFRA • CD19 • PDGFRB • CSF1R
    |
    CD19 expression
    |
    dasatinib • imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • Blincyto (blinatumomab) • methotrexate • vincristine • daunorubicin • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Starasid (cytarabine ocfosfate)
    A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias (NCT05521087)
    Phase 1
    Janssen Research & Development, LLC
    Not yet recruiting
    Last update posted :
    11/09/2023
    Initiation :
    02/07/2024
    Primary completion :
    09/11/2026
    Completion :
    09/11/2026
    NPM1 • KMT2A • NUP98 • NUP214
    |
    cytarabine • vincristine • Oncaspar liquid (pegaspargase) • fludarabine IV • JNJ-6617
    Testing the Use of Steroids and Tyrosine Kinase Inhibitors With Blinatumomab or Chemotherapy for Newly Diagnosed BCR-ABL-Positive Acute Lymphoblastic Leukemia in Adults (NCT04530565)
    Phase 3
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    11/08/2023
    Initiation :
    01/25/2021
    Primary completion :
    07/01/2028
    Completion :
    07/01/2028
    ABL1 • BCR
    |
    ABL1 T315I
    |
    dasatinib • cytarabine • Iclusig (ponatinib) • doxorubicin hydrochloride • cyclophosphamide • Blincyto (blinatumomab) • methotrexate • vincristine • Hemady (dexamethasone tablets) • Starasid (cytarabine ocfosfate) • dexamethasone injection
    Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial) (NCT05554393)
    Phase 2
    National Cancer Institute (NCI)
    Not yet recruiting
    Last update posted :
    11/08/2023
    Initiation :
    12/31/2023
    Primary completion :
    12/31/2023
    Completion :
    12/31/2023
    TP53 • FLT3 • NPM1 • RUNX1 • ASXL1 • RARA • RUNX1T1 • PML • CEBPA
    |
    TP53 mutation • FLT3-ITD mutation • NPM1 mutation • RUNX1 mutation • ASXL1 mutation • FLT3-TKD mutation • CEBPA mutation
    |
    Venclexta (venetoclax) • cytarabine • azacitidine • daunorubicin • Starasid (cytarabine ocfosfate)
    Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia (ECOG-ACRIN E1910) (NCT02003222)
    Phase 3
    National Cancer Institute (NCI)
    Active, not recruiting
    Last update posted :
    11/08/2023
    Initiation :
    05/19/2014
    Primary completion :
    12/31/2023
    Completion :
    12/31/2023
    ABL1 • CDKN2A • CD20 • RUNX1 • IGH • ETV6 • CD4 • TCF3 • PBX1
    |
    Rituxan (rituximab) • cytarabine • cyclophosphamide • etoposide IV • Blincyto (blinatumomab) • methotrexate • vincristine • daunorubicin • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Riabni (rituximab-arrx) • Delito (rituximab biosimilar) • Hemady (dexamethasone tablets) • GB241 (rituximab biosimilar) • JHL1101 (rituximab biosimilar) • Mabtas (rituximab biosimilar) • Novex (rituximab biosimilar) • SIBP-02 (rituximab biosimilar) • Starasid (cytarabine ocfosfate)
    Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia (NCT03808610)
    Phase 1/2
    M.D. Anderson Cancer Center
    Recruiting
    Last update posted :
    11/06/2023
    Initiation :
    04/03/2019
    Primary completion :
    12/31/2026
    Completion :
    12/31/2026
    BCL2
    |
    Venclexta (venetoclax) • Rituxan (rituximab) • cytarabine • cyclophosphamide • methotrexate • vincristine • Oncaspar liquid (pegaspargase) • nelarabine • Riabni (rituximab-arrx) • Delito (rituximab biosimilar) • GB241 (rituximab biosimilar) • Novex (rituximab biosimilar) • Starasid (cytarabine ocfosfate)
    Auto Stem Cell Transplant for Lymphoma Patients (NCT03125642)
    Phase 2
    Masonic Cancer Center, University of Minnesota
    Recruiting
    Last update posted :
    11/02/2023
    Initiation :
    04/20/2017
    Primary completion :
    09/30/2025
    Completion :
    04/30/2026
    ALK • CD4 • TCL1A
    |
    ALK positive
    |
    cytarabine • cyclophosphamide • etoposide IV • carmustine • melphalan • Neupogen (filgrastim)
    Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane (NCI-2021-10020) (NCT05146739)
    Phase 1
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    11/02/2023
    Initiation :
    12/23/2023
    Primary completion :
    12/31/2024
    Completion :
    12/31/2024
    SELL
    |
    cytarabine • leucovorin calcium • fludarabine IV • uproleselan sodium (APL-106) • Starasid (cytarabine ocfosfate)