[{"id":"307f58ff-e40c-4fdc-bf96-004db83003a0","acronym":"","url":"https://clinicaltrials.gov/study/NCT06076837","created_at":"2023-10-11T16:12:25.578Z","updated_at":"2024-07-02T16:35:33.893Z","phase":"Phase 1","brief_title":"The Seven Trial: Exploiting the Unfolded Protein Response","source_id_and_acronym":"NCT06076837","lead_sponsor":"HonorHealth Research Institute","biomarkers":" CEACAM5 • MUC16","pipe":"","alterations":" ","tags":["CEACAM5 • MUC16"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e cisplatin • gemcitabine • albumin-bound paclitaxel • balstilimab (AGEN2034) • botensilimab (AGEN1181) • celecoxib oral • chloroquine phosphate"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 12","initiation":"Initiation: 12/01/2023","start_date":" 12/01/2023","primary_txt":" Primary completion: 06/01/2025","primary_completion_date":" 06/01/2025","study_txt":" Completion: 12/01/2025","study_completion_date":" 12/01/2025","last_update_posted":"2023-10-11"},{"id":"a9582e3e-99d1-4d84-a6a1-43c23c55626e","acronym":"","url":"https://clinicaltrials.gov/study/NCT05647330","created_at":"2022-12-12T15:00:26.571Z","updated_at":"2024-07-02T16:35:59.264Z","phase":"Phase 2","brief_title":"Hydroxychloroquine Combined With Gemcitabine in the Treatment of Advanced Non-small Cell Lung Cancer","source_id_and_acronym":"NCT05647330","lead_sponsor":"Henan Cancer Hospital","biomarkers":" EGFR • ALK","pipe":" | ","alterations":" EGFR mutation • ALK mutation • EGFR negative","tags":["EGFR • ALK"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e EGFR mutation • ALK mutation • EGFR negative"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e gemcitabine • hydroxychloroquine • chloroquine phosphate"],"overall_status":"Not yet recruiting","enrollment":" Enrollment 55","initiation":"Initiation: 12/15/2022","start_date":" 12/15/2022","primary_txt":" Primary completion: 10/01/2024","primary_completion_date":" 10/01/2024","study_txt":" Completion: 10/01/2025","study_completion_date":" 10/01/2025","last_update_posted":"2022-12-12"},{"id":"e0ef7baa-0ff6-47b2-b5a1-b9f6fa007c32","acronym":"PINC","url":"https://clinicaltrials.gov/study/NCT01023477","created_at":"2021-01-18T04:00:49.570Z","updated_at":"2024-07-02T16:36:28.537Z","phase":"Phase 1/2","brief_title":"Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial)","source_id_and_acronym":"NCT01023477 - PINC","lead_sponsor":"Inova Health Care Services","biomarkers":" HMGB1 • CD68 • PCNA","pipe":"","alterations":" ","tags":["HMGB1 • CD68 • PCNA"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e chloroquine phosphate"],"overall_status":"Completed","enrollment":" Enrollment 12","initiation":"Initiation: 12/01/2009","start_date":" 12/01/2009","primary_txt":" Primary completion: 10/01/2016","primary_completion_date":" 10/01/2016","study_txt":" Completion: 10/01/2016","study_completion_date":" 10/01/2016","last_update_posted":"2021-06-29"},{"id":"cff6c91c-e6d9-403a-9a14-84429bc14161","acronym":"MACIST","url":"https://clinicaltrials.gov/study/NCT02496741","created_at":"2021-01-18T12:02:25.667Z","updated_at":"2024-07-02T16:36:51.534Z","phase":"Phase 1/2","brief_title":"Metformin And Chloroquine in IDH1/2-mutated Solid Tumors","source_id_and_acronym":"NCT02496741 - MACIST","lead_sponsor":"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","biomarkers":" IDH1 • IDH2","pipe":" | ","alterations":" IDH1 mutation • IDH2 mutation","tags":["IDH1 • IDH2"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e IDH1 mutation • IDH2 mutation"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e metformin • chloroquine phosphate"],"overall_status":"Completed","enrollment":" Enrollment 15","initiation":"Initiation: 11/01/2015","start_date":" 11/01/2015","primary_txt":" Primary completion: 11/18/2019","primary_completion_date":" 11/18/2019","study_txt":" Completion: 11/18/2019","study_completion_date":" 11/18/2019","last_update_posted":"2020-01-09"},{"id":"bb2c492c-969f-413d-9a8a-e5a2b2a988fd","acronym":"CUBiC","url":"https://clinicaltrials.gov/study/NCT02333890","created_at":"2022-06-02T09:58:02.488Z","updated_at":"2024-07-02T16:37:27.543Z","phase":"Phase 2","brief_title":"A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer","source_id_and_acronym":"NCT02333890 - CUBiC","lead_sponsor":"Ottawa Hospital Research Institute","biomarkers":" BECN1","pipe":"","alterations":" ","tags":["BECN1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e chloroquine phosphate"],"overall_status":"Unknown status","enrollment":" Enrollment 60","initiation":"Initiation: 07/01/2015","start_date":" 07/01/2015","primary_txt":" Primary completion: 03/01/2017","primary_completion_date":" 03/01/2017","study_txt":" Completion: 03/01/2018","study_completion_date":" 03/01/2018","last_update_posted":"2016-11-18"}]