[{"id":"8086c59c-d398-45e2-9f6f-5158e36590e7","acronym":"PalboSarc","url":"https://clinicaltrials.gov/study/NCT03242382","created_at":"2021-01-18T16:01:11.999Z","updated_at":"2024-07-02T16:35:22.689Z","phase":"Phase 2","brief_title":"Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression.","source_id_and_acronym":"NCT03242382 - PalboSarc","lead_sponsor":"Grupo Espanol de Investigacion en Sarcomas","biomarkers":" CDKN2A • CDK4","pipe":" | ","alterations":" CDKN2A mutation • CDK4 overexpression","tags":["CDKN2A • CDK4"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CDKN2A mutation • CDK4 overexpression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ibrance (palbociclib)"],"overall_status":"Recruiting","enrollment":" Enrollment 40","initiation":"Initiation: 03/31/2017","start_date":" 03/31/2017","primary_txt":" Primary completion: 09/30/2024","primary_completion_date":" 09/30/2024","study_txt":" Completion: 09/30/2024","study_completion_date":" 09/30/2024","last_update_posted":"2024-01-23"},{"id":"e8456c97-4ee4-47f4-89b8-43e1a9f2db63","acronym":"PALBONET","url":"https://clinicaltrials.gov/study/NCT02806648","created_at":"2021-01-18T13:45:55.470Z","updated_at":"2024-07-02T16:37:14.609Z","phase":"Phase 2","brief_title":"A Trial to Assess the Activity and Safety of Palbociclib in Patients With Well and Moderately Differentiated Metastatic Pancreatic Neuroendocrine Tumors (pNET)","source_id_and_acronym":"NCT02806648 - PALBONET","lead_sponsor":"Grupo Espanol de Tumores Neuroendocrinos","biomarkers":" RB1 • CCND1 • CDK4 • CDK6","pipe":" | ","alterations":" CCND1 overexpression • CDK4 overexpression • RB1 overexpression • CDK6 expression","tags":["RB1 • CCND1 • CDK4 • CDK6"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e CCND1 overexpression • CDK4 overexpression • RB1 overexpression • CDK6 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e Ibrance (palbociclib)"],"overall_status":"Completed","enrollment":" Enrollment 21","initiation":"Initiation: 05/01/2015","start_date":" 05/01/2015","primary_txt":" Primary completion: 07/01/2017","primary_completion_date":" 07/01/2017","study_txt":" Completion: 01/01/2018","study_completion_date":" 01/01/2018","last_update_posted":"2018-01-23"}]