[{"id":"ba1ff799-4c96-4b36-abc9-9696cce6175e","acronym":"NCI-2018-01836","url":"https://clinicaltrials.gov/study/NCT00494182","created_at":"2021-01-18T01:46:04.063Z","updated_at":"2024-07-02T16:35:01.215Z","phase":"Phase 2","brief_title":"Sorafenib in Combination With Carboplatin and Paclitaxel in Treating Participants With Metastatic or Recurrent Head and Neck Squamous Cell Cancer","source_id_and_acronym":"NCT00494182 - NCI-2018-01836","lead_sponsor":"M.D. Anderson Cancer Center","biomarkers":" HER-2 • TP53 • HIF1A • CD34 • EPAS1 • CD31 • PECAM1","pipe":" | ","alterations":" TP53 mutation • HER-2 expression • TP53 expression • CD31 expression • HIF1A expression • CA9 expression","tags":["HER-2 • TP53 • HIF1A • CD34 • EPAS1 • CD31 • PECAM1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e TP53 mutation • HER-2 expression • TP53 expression • CD31 expression • HIF1A expression • CA9 expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e carboplatin • sorafenib • paclitaxel"],"overall_status":"Active, not recruiting","enrollment":" Enrollment 48","initiation":"Initiation: 04/25/2007","start_date":" 04/25/2007","primary_txt":" Primary completion: 12/31/2025","primary_completion_date":" 12/31/2025","study_txt":" Completion: 12/31/2025","study_completion_date":" 12/31/2025","last_update_posted":"2024-05-24"},{"id":"8ecb7624-1e34-46a2-8e81-e407b465fc51","acronym":"","url":"https://clinicaltrials.gov/study/NCT00052611","created_at":"2021-01-18T00:05:52.353Z","updated_at":"2024-07-02T16:37:12.672Z","phase":"Phase 2","brief_title":"Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia","source_id_and_acronym":"NCT00052611","lead_sponsor":"Dana-Farber Cancer Institute","biomarkers":" BCL2 • AKT1 • BAX • PTGS2 • CD31 • PECAM1","pipe":" | ","alterations":" BCL2 expression • BAX expression • CD31 expression • PTGS2 expression • VEGFA expression","tags":["BCL2 • AKT1 • BAX • PTGS2 • CD31 • PECAM1"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e BCL2 expression • BAX expression • CD31 expression • PTGS2 expression • VEGFA expression"," \u003cb class=\"violet\"\u003e|\u003c/b\u003e celecoxib oral"],"overall_status":"Completed","enrollment":" Enrollment 23","initiation":"Initiation: 06/01/2002","start_date":" 06/01/2002","primary_txt":" Primary completion: 03/01/2005","primary_completion_date":" 03/01/2005","study_txt":" Completion: 03/01/2005","study_completion_date":" 03/01/2005","last_update_posted":"2018-03-29"}]