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    CCR5 receptor antagonist

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    Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ... (NCT05470491)
    Phase 1/2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    02/20/2025
    Initiation :
    01/26/2023
    Primary completion :
    07/30/2026
    Completion :
    07/30/2027
    IGH
    |
    bortezomib • cyclophosphamide • Selzentry (maraviroc) • plerixafor
    Trial of Neoadjuvant and Adjuvant Nivolumab and BMS-813160 With or Without GVAX for Locally Advanced Pancreatic Ductal Adenocarcinomas. (NCT03767582)
    Phase 1/2
    Sidney Kimmel Comprehensive Cancer Center at Jo...
    Completed
    Last update posted :
    12/10/2024
    Initiation :
    12/12/2019
    Primary completion :
    09/30/2024
    Completion :
    09/30/2024
    TNFRSF9
    |
    Opdivo (nivolumab) • BMS-813160 • GVAX Pancreas (allogeneic GM-CSF-secreting tumor cells)
    Combined PD-1 and CCR5 Inhibition for the Treatment of Refractory Microsatellite Stable mCRC (PICCASSO) (NCT03274804)
    Phase 1
    University Hospital Heidelberg
    Completed
    Last update posted :
    06/07/2022
    Initiation :
    04/01/2018
    Primary completion :
    03/01/2020
    Completion :
    03/01/2020
    BRAF
    |
    BRAF wild-type
    |
    Keytruda (pembrolizumab) • Selzentry (maraviroc)
    Leronlimab (PRO 140) Combined With Carboplatin in Patients With CCR5+ mTNBC (NCT03838367)
    Phase 1/2
    CytoDyn, Inc.
    Active, not recruiting
    Last update posted :
    03/21/2022
    Initiation :
    04/22/2019
    Primary completion :
    07/15/2022
    Completion :
    09/16/2022
    HER-2 • PD-L1
    |
    HER-2 negative
    |
    carboplatin • Vyrologix (leronlimab)
    A Compassionate Use Study of Leronlimab in Breast Cancer (NCT04313075)
    Phase N/A
    CytoDyn, Inc.
    No Longer Available
    Last update posted :
    01/28/2022
    HER-2
    |
    HER-2 negative
    |
    Vyrologix (leronlimab)
    Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS) (NCT01276236)
    Phase 2
    University of California, San Francisco
    Completed
    Last update posted :
    03/05/2021
    Initiation :
    03/09/2011
    Primary completion :
    01/31/2015
    Completion :
    04/30/2015
    CD8 • CD38 • CD4 • CD69
    |
    CD38 positive • CD8 negative
    |
    Selzentry (maraviroc)
    Phase II Maraviroc for GVHD Prevention (NCT01785810)
    Phase 2
    Abramson Cancer Center of the University of Pen...
    Completed
    Last update posted :
    01/11/2021
    Initiation :
    02/01/2013
    Primary completion :
    11/11/2016
    Completion :
    07/12/2018
    HLA-DRB1 • HLA-B • HLA-C
    |
    Selzentry (maraviroc)