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BIOMARKER:

BRCA1 mutation + BRCA2 mutation

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Other names: BRCA2, BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, Breast cancer 2, early onset, BRCA1, BRCC1, PPP1R53, RNF53, Breast cancer 1, early onset
Entrez ID:
Phase 1/2
National Cancer Institute (NCI)
Recruiting
Last update posted :
06/07/2024
Initiation :
06/29/2015
Primary completion :
12/30/2024
Completion :
12/30/2025
EGFR • HER-2 • BRAF • ALK • PGR • BRCA1 • BRCA2
|
BRAF V600E • BRCA2 mutation • BRCA1 mutation • EGFR mutation • BRAF V600 • ALK translocation • BRCA1 mutation + BRCA2 mutation
|
Lynparza (olaparib) • Imfinzi (durvalumab) • Recentin (cediranib)
Phase 2
Spanish Breast Cancer Research Group
Completed
Last update posted :
06/06/2024
Initiation :
10/23/2017
Primary completion :
12/15/2022
Completion :
12/15/2022
HER-2 • ER • PGR • BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • HER-2 negative • BRCA1 mutation + BRCA2 mutation • BRCA mutation • PGR expression • BRCA1 promoter methylation
|
Lynparza (olaparib)
Phase 1
Nerviano Medical Sciences
Active, not recruiting
Last update posted :
04/22/2024
Initiation :
11/25/2019
Primary completion :
03/31/2023
Completion :
12/30/2024
HER-2 • BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • HER-2 negative • BRCA1 mutation + BRCA2 mutation
|
NMS-293
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
04/05/2024
Initiation :
09/01/2016
Primary completion :
05/01/2019
Completion :
03/05/2025
BRCA1 • BRCA2 • HRD • CEACAM5
|
BRCA2 mutation • BRCA1 mutation • HRD • HRD + BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
|
5-fluorouracil • irinotecan • veliparib (ABT-888) • leucovorin calcium • fluorouracil topical
Phase N/A
Memorial Sloan Kettering Cancer Center
Recruiting
Last update posted :
02/02/2024
Initiation :
01/01/2009
Primary completion :
01/01/2025
Completion :
01/01/2025
HER-2 • BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • HER-2 overexpression • BRCA1 mutation + BRCA2 mutation
Phase N/A
AstraZeneca
Not yet recruiting
Last update posted :
01/24/2024
Initiation :
03/04/2024
Primary completion :
09/30/2024
Completion :
09/30/2024
HER-2 • ER • PIK3CA • BRCA1 • PTEN • ATM • AKT1
|
BRCA2 mutation • BRCA1 mutation • HER-2 negative • PIK3CA mutation • HER-2 expression • ATM mutation • PALB2 mutation • ESR1 mutation • BRCA1 mutation + BRCA2 mutation
Phase N/A
Memorial Sloan Kettering Cancer Center
Active, not recruiting
Last update posted :
11/14/2023
Initiation :
07/01/1996
Primary completion :
07/01/2025
Completion :
07/01/2025
BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
Phase N/A
Banaras Hindu University
Recruiting
Last update posted :
06/06/2022
Initiation :
07/01/2021
Primary completion :
12/31/2024
Completion :
12/31/2024
BRCA1 • BRCA2 • AR • BRCA
|
BRCA2 mutation • BRCA1 mutation • AR expression • BRCA1 mutation + BRCA2 mutation • BRCA mutation
Phase N/A
AstraZeneca
Completed
Last update posted :
10/26/2021
Initiation :
03/19/2020
Primary completion :
11/13/2020
Completion :
11/13/2020
BRCA1 • BRCA2
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
Phase 1
Dana-Farber Cancer Institute
Completed
Last update posted :
02/10/2021
Initiation :
09/01/2012
Primary completion :
05/01/2019
Completion :
12/01/2020
BRCA1 • BRCA
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation
|
Lynparza (olaparib) • Piqray (alpelisib) • buparlisib (AN2025)
Phase N/A
AstraZeneca
Completed
Last update posted :
07/16/2020
Initiation :
07/16/2017
Primary completion :
07/24/2019
Completion :
07/24/2019
BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation • BRCA mutation
Phase N/A
AstraZeneca
Completed
Last update posted :
07/10/2020
Initiation :
12/27/2016
Primary completion :
06/30/2019
Completion :
06/30/2019
BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation + BRCA2 mutation • BRCA mutation
Phase N/A
Abramson Cancer Center of the University of Pen...
Completed
Last update posted :
07/24/2019
Initiation :
07/01/2014
Primary completion :
10/01/2018
Completion :
10/01/2018
BRCA1 • BRCA2
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation • BRCA1 negative
Phase N/A
Memorial Sloan Kettering Cancer Center
Withdrawn
Last update posted :
02/19/2018
Initiation :
07/01/2000
Primary completion :
07/01/2018
Completion :
07/01/2018
BRCA1 • BRCA2 • BRCA
|
BRCA2 mutation • BRCA1 mutation • BRCA1 mutation + BRCA2 mutation