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BIOMARKER:
BRAF mutation
i
Other names:
BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Related tests:
Oncomine™ Dx Target Test (11)
Idylla™ ctNRAS-BRAF Mutation Test
Lung Cancer 8-Gene Kit
Oncomine™ Dx Target Test (11)
Idylla™ ctNRAS-BRAF Mutation Test
Lung Cancer 8-Gene Kit
Associations
(129)
News
Trials
Phase
Status
Apply
Phase
Status
Apply
The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer (NCT03841617)
Phase 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
National Institute of Diabetes and Dige...
Recruiting
Phase 2
National Institute of Diabetes and Digestive an...
Recruiting
Last update posted :
02/24/2025
Initiation :
07/29/2019
Primary completion :
02/01/2030
Completion :
02/01/2030
BRAF • TG
|
BRAF mutation
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma (NCT04923126)
Phase 1/2
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital
Recruiting
Phase 1/2
St. Jude Children's Research Hospital
Recruiting
Last update posted :
02/24/2025
Initiation :
06/21/2021
Primary completion :
06/01/2031
Completion :
06/01/2031
BRAF • NF1 • PTPN11 • MYBL1
|
BRAF mutation
|
Gomekli (mirdametinib)
Gene Modified Immune Cells (IL13Ralpha2 CAR T Cells) After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors (NCT04119024)
Phase 1
Jonsson Comprehensive Cancer Center
Jonsson Comprehensive Cancer Center
Recruiting
Phase 1
Jonsson Comprehensive Cancer Center
Recruiting
Last update posted :
02/24/2025
Initiation :
11/27/2019
Primary completion :
10/01/2025
Completion :
10/01/2026
BRAF
|
BRAF mutation • BRAF V600
|
cyclophosphamide • fludarabine IV • Imunace (teceleukin) • MB-101 • cyclophosphamide intravenous
Ipilimumab With or Without Bevacizumab in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery (NCT01950390)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/24/2025
Initiation :
01/24/2014
Primary completion :
10/06/2021
Completion :
01/31/2026
BRAF
|
BRAF mutation • BRAF wild-type
|
Avastin (bevacizumab) • Yervoy (ipilimumab) • Aybintio (bevacizumab biosimilar) • Mvasi (bevacizumab-awwb) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • Zirabev (bevacizumab-bvzr) • Jobevne (bevacizumab-nwgd) • CS1002 (ipilimumab biosimilar) • Airuituo (bevacizumab biosimilar) • Beianting (bevacizumab biosimilar) • Boyounuo (bevacizumab biosimilar) • GB222 (bevacizumab biosimilar) • Hanbeitai (bevacizumab biosimilar) • Vasforda (bevacizumab biosimilar)
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma (NCT02339571)
Phase 2/3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2/3
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/24/2025
Initiation :
11/23/2015
Primary completion :
06/30/2033
Completion :
06/30/2033
BRAF
|
BRAF mutation • BRAF wild-type
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • CS1002 (ipilimumab biosimilar) • ABP 206 (nivolumab biosimilar) • CMAB 819 (nivolumab biosimilar) • Leukine (sargramostim)
Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer (NCI-2021-11793) (NCT05111561)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Suspended
Phase 1
National Cancer Institute (NCI)
Suspended
Last update posted :
02/21/2025
Initiation :
08/02/2022
Primary completion :
03/14/2025
Completion :
03/14/2025
HER-2 • KRAS • BRAF • ER • PGR • NRAS • HRAS • NF1
|
BRAF mutation • HER-2 amplification • HRAS mutation • BRAF fusion
|
Mektovi (binimetinib) • ZEN-3694
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients (NCT05078866)
Phase 1/2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 1/2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/21/2025
Initiation :
11/10/2022
Primary completion :
07/31/2025
Completion :
07/31/2025
BRAF • MSI • MLH1 • MSH6 • MSH2
|
BRAF mutation
|
NOUS-209
A Study of Multiple Therapies in Biomarker-Selected Patients With Resectable Stages IB-III Non-Small Cell Lung Cancer (NAUTIKA1) (NCT04302025)
Phase 2
Genentech, Inc.
Genentech, Inc.
Recruiting
Phase 2
Genentech, Inc.
Recruiting
Last update posted :
02/21/2025
Initiation :
11/06/2020
Primary completion :
12/30/2025
Completion :
03/06/2029
PD-L1 • KRAS • BRAF • ALK • RET • ROS1 • NTRK1 • NTRK3 • NTRK2
|
PD-L1 expression • KRAS mutation • KRAS G12C • BRAF mutation • BRAF V600 • RET fusion • ALK fusion • RET mutation • ROS1 fusion • KRAS G12
|
Tecentriq (atezolizumab) • Zelboraf (vemurafenib) • Rozlytrek (entrectinib) • Alecensa (alectinib) • Cotellic (cobimetinib) • Gavreto (pralsetinib) • divarasib (RG6330)
Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations (NCT06043713)
Phase 1
Fred Hutchinson Cancer Center
Fred Hutchinson Cancer Center
Active, not recruiting
Phase 1
Fred Hutchinson Cancer Center
Active, not recruiting
Last update posted :
02/21/2025
Initiation :
12/15/2023
Primary completion :
12/31/2025
Completion :
02/09/2026
HER-2 • KRAS • BRAF • ALK • TMB • MSI • NTRK
|
KRAS mutation • TMB-H • BRAF mutation • HER-2 amplification • ROS1 fusion • KRAS G12 • NTRK fusion
|
cyclophosphamide • bendamustine • fludarabine IV
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial (NCT05554328)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Recruiting
Phase 2
National Cancer Institute (NCI)
Recruiting
Last update posted :
02/20/2025
Initiation :
04/25/2023
Primary completion :
10/01/2028
Completion :
10/01/2028
KRAS • BRAF • NRAS • HRAS • MAP2K1 • NF1 • MAP2K2
|
KRAS mutation • BRAF mutation • NRAS mutation • RAS mutation • HRAS mutation
|
Lynparza (olaparib) • Koselugo (selumetinib)
ACT-TIL and ANV419 for Advanced Melanoma. (BaseTIL-03M) (NCT05869539)
Phase 1
University Hospital, Basel, Switzerland
University Hospital, Basel, Switzerland
Recruiting
Phase 1
University Hospital, Basel, Switzerland
Recruiting
Last update posted :
02/20/2025
Initiation :
06/21/2023
Primary completion :
06/01/2025
Completion :
06/01/2025
BRAF
|
BRAF mutation • BRAF V600
|
ANV419
A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors (SGNBB228-001) (NCT05571839)
Phase 1
Seagen, a wholly owned subsidiary of Pfizer
Seagen, a wholly owned subsidiary of Pf...
Recruiting
Phase 1
Seagen, a wholly owned subsidiary of Pfizer
Recruiting
Last update posted :
02/19/2025
Initiation :
01/03/2023
Primary completion :
04/19/2027
Completion :
04/18/2028
BRAF
|
BRAF mutation
|
PF-08046049
Safety and Efficacy of OBX-115 in Advanced Solid Tumors (Agni-01) (NCT06060613)
Phase 1/2
Obsidian Therapeutics, Inc.
Obsidian Therapeutics, Inc.
Recruiting
Phase 1/2
Obsidian Therapeutics, Inc.
Recruiting
Last update posted :
02/19/2025
Initiation :
10/25/2023
Primary completion :
10/30/2025
Completion :
10/30/2027
PD-L1 • BRAF • PD-1
|
BRAF mutation • BRAF V600
|
cyclophosphamide • fludarabine IV • OBX-115
Sasanlimab (PF-06801591, PD-1 Inhibitor) in Participants With Advanced Malignancies (NCT04181788)
Phase 2
Pfizer
Pfizer
Active, not recruiting
Phase 2
Pfizer
Active, not recruiting
Last update posted :
02/18/2025
Initiation :
03/18/2020
Primary completion :
03/03/2022
Completion :
04/30/2025
EGFR • PD-L1 • BRAF • ALK • ROS1
|
PD-L1 expression • EGFR mutation • BRAF mutation • ALK translocation
|
sasanlimab (PF-06801591)
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) (NCT05099003)
Phase 1/2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Suspended
Phase 1/2
National Cancer Institute (NCI)
Suspended
Last update posted :
02/18/2025
Initiation :
05/31/2022
Primary completion :
06/30/2027
Completion :
06/30/2027
BRAF • IDH1
|
BRAF mutation • BRAF V600 • IDH1 mutation
|
Xpovio (selinexor)
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors (ST101-101) (NCT04478279)
Phase 1/2
Sapience Therapeutics
Sapience Therapeutics
Active, not recruiting
Phase 1/2
Sapience Therapeutics
Active, not recruiting
Last update posted :
02/17/2025
Initiation :
07/01/2020
Primary completion :
12/01/2025
Completion :
12/01/2025
BRAF
|
HR positive • BRAF mutation
|
temozolomide • Xtandi (enzalutamide) • abiraterone acetate • lucicebtide (ST101)
TAC T-cells for the Treatment of Claudin 18.2 Positive Solid Tumors (TACTIC-3) (NCT05862324)
Phase 1/2
Triumvira Immunologics, Inc.
Triumvira Immunologics, Inc.
Active, not recruiting
Phase 1/2
Triumvira Immunologics, Inc.
Active, not recruiting
Last update posted :
02/14/2025
Initiation :
08/23/2023
Primary completion :
08/01/2027
Completion :
08/01/2027
EGFR • HER-2 • BRAF • ALK • CLDN18 • BRCA
|
EGFR mutation • BRAF mutation • HER-2 expression • CLDN18.2 positive • ALK translocation • BRCA mutation
|
albumin-bound paclitaxel • cyclophosphamide • fludarabine IV • TAC101-Claudin18.2
Denosumab and Nivolumab Combination As 2d-line Therapy in Stage IV NSC Lung Cancer with Bone Metastases (DENIVOS) (NCT03669523)
Phase 2
Centre Hospitalier Annecy Genevois
Centre Hospitalier Annecy Genevois
Completed
Phase 2
Centre Hospitalier Annecy Genevois
Completed
Last update posted :
02/13/2025
Initiation :
11/06/2018
Primary completion :
10/19/2023
Completion :
10/19/2023
EGFR • PD-L1 • BRAF • ALK
|
PD-L1 expression • EGFR mutation • BRAF mutation • BRAF V600 • ALK translocation
|
Opdivo (nivolumab) • Prolia (denosumab) • zoledronic acid
A Study to Evaluate Enfortumab Vedotin in Subjects With Locally Advanced or Metastatic Malignant Solid Tumors (EV-202) (KEYNOTE-F21) (NCT04225117)
Phase 2
Astellas Pharma Global Development, Inc.
Astellas Pharma Global Development, Inc.
Active, not recruiting
Phase 2
Astellas Pharma Global Development, Inc.
Active, not recruiting
Last update posted :
02/12/2025
Initiation :
03/09/2020
Primary completion :
09/30/2026
Completion :
09/30/2026
BRAF • ER • ALK • PGR
|
PD-L1 expression • HER-2 positive • ER positive • EGFR mutation • BRAF mutation • HER-2 negative • ER negative • HER-2 negative + ER positive
|
Keytruda (pembrolizumab) • Padcev (enfortumab vedotin-ejfv)
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With Advanced Solid Tumors. (SAKK 66/17) (NCT03993678)
Phase 1/2
Swiss Group for Clinical Cancer Research
Swiss Group for Clinical Cancer Research
Recruiting
Phase 1/2
Swiss Group for Clinical Cancer Research
Recruiting
Last update posted :
02/12/2025
Initiation :
10/12/2020
Primary completion :
06/30/2025
Completion :
12/31/2025
BRAF
|
BRAF mutation
|
IP-001
Axitinib + Ipilimumab in Advanced Melanoma (NCT04996823)
Phase 2
H. Lee Moffitt Cancer Center and Research Institute
H. Lee Moffitt Cancer Center and Resear...
Recruiting
Phase 2
H. Lee Moffitt Cancer Center and Research Insti...
Recruiting
Last update posted :
02/12/2025
Initiation :
08/04/2021
Primary completion :
03/29/2026
Completion :
03/29/2027
BRAF
|
BRAF mutation • BRAF V600
|
Yervoy (ipilimumab) • Inlyta (axitinib)
A Clinical Study of SI-B001 Combined With Docetaxel in the Treatment of Non-small Cell Lung Adenocarcinoma and Lung Squamous Cell Carcinoma (NCT05943795)
Phase 3
Sichuan Baili Pharmaceutical Co., Ltd.
Sichuan Baili Pharmaceutical Co., Ltd.
Recruiting
Phase 3
Sichuan Baili Pharmaceutical Co., Ltd.
Recruiting
Last update posted :
02/11/2025
Initiation :
07/14/2023
Primary completion :
07/01/2026
Completion :
07/01/2026
EGFR • HER-2 • KRAS • BRAF • ALK • ROS1 • NTRK
|
KRAS mutation • KRAS G12C • BRAF mutation • HER-2 amplification • BRAF V600 • KRAS G12D • EGFR wild-type • RET mutation • ALK wild-type • ROS1 fusion • ROS1 rearrangement • RET rearrangement • KRAS G12 • KRAS amplification • NTRK fusion
|
docetaxel • izalontamab (SI-B001)
Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer (NCT02188264)
Phase 1
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Completed
Phase 1
National Cancer Institute (NCI)
Completed
Last update posted :
02/11/2025
Initiation :
08/29/2014
Primary completion :
01/31/2017
Completion :
04/26/2019
BRAF • RAF1 • MAPK1
|
BRAF mutation • RAS mutation
|
Koselugo (selumetinib) • cyclosporin A microemulsion
PLATFORM Study of Precision Medicine for Rare Tumors (NCT04423185)
Phase 2
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cancer Institute and Hospital, Chinese ...
Recruiting
Phase 2
Cancer Institute and Hospital, Chinese Academy ...
Recruiting
Last update posted :
02/11/2025
Initiation :
08/15/2020
Primary completion :
07/01/2026
Completion :
07/01/2028
EGFR • HER-2 • BRAF • ALK • MET • BRCA1 • BRCA2 • KIT • ROS1 • CDKN2A
|
BRCA2 mutation • BRCA1 mutation • EGFR mutation • HER-2 overexpression • BRAF mutation • HER-2 amplification • MET amplification • KIT mutation • ALK fusion • ROS1 fusion • CDKN2A mutation • MET mutation • BRAF amplification
|
Xalkori (crizotinib) • Tecentriq (atezolizumab) • Ibrance (palbociclib) • Zelboraf (vemurafenib) • imatinib • Tyvyt (sintilimab) • Alecensa (alectinib) • Zejula (niraparib) • Irene (pyrotinib) • Ameile (aumolertinib) • Vizimpro (dacomitinib)
Trial With BNT111 and Cemiplimab in Combination or as Single Agents in Patients With Anti-PD-1-refractory/Relapsed, Unresectable Stage III or IV Melanoma (BNT111-01) (NCT04526899)
Phase 2
BioNTech SE
BioNTech SE
Active, not recruiting
Phase 2
BioNTech SE
Active, not recruiting
Last update posted :
02/10/2025
Initiation :
05/19/2021
Primary completion :
01/25/2024
Completion :
07/01/2026
BRAF
|
BRAF mutation • BRAF V600
|
Libtayo (cemiplimab-rwlc) • BNT111
Ipilimumab With Lymphodepletion Plus Adoptive Cell Transfer and High Dose IL-2 in Melanoma Mets Pts (NCT01701674)
Phase N/A
H. Lee Moffitt Cancer Center and Research Institute
H. Lee Moffitt Cancer Center and Resear...
Active, not recruiting
Phase N/A
H. Lee Moffitt Cancer Center and Research Insti...
Active, not recruiting
Last update posted :
02/10/2025
Initiation :
10/09/2012
Primary completion :
04/21/2016
Completion :
09/08/2025
BRAF
|
BRAF mutation • BRAF V600 • BRAF wild-type
|
Yervoy (ipilimumab) • cyclophosphamide • fludarabine IV • Proleukin (aldesleukin) • cyclophosphamide intravenous
Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants With Advanced Melanoma (MK-3475-555/KEYNOTE-555) (NCT03665597)
Phase 1
Merck Sharp & Dohme LLC
Merck Sharp & Dohme LLC
Completed
Phase 1
Merck Sharp & Dohme LLC
Completed
Last update posted :
02/10/2025
Initiation :
11/19/2018
Primary completion :
12/04/2023
Completion :
12/04/2023
BRAF • TNFRSF9
|
BRAF mutation • BRAF V600
|
Keytruda (pembrolizumab) • MK-3475 SC
A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib (DURAFAK) (NCT05512208)
Phase 2
University of Oklahoma
University of Oklahoma
Recruiting
Phase 2
University of Oklahoma
Recruiting
Last update posted :
02/10/2025
Initiation :
02/06/2023
Primary completion :
12/01/2027
Completion :
12/01/2029
BRAF • NF1 • RAS
|
BRAF mutation • RAS mutation
|
avutometinib (VS-6766) • defactinib (VS-6063)
XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma (NCT02721459)
Phase 1
H. Lee Moffitt Cancer Center and Research Institute
H. Lee Moffitt Cancer Center and Resear...
Active, not recruiting
Phase 1
H. Lee Moffitt Cancer Center and Research Insti...
Active, not recruiting
Last update posted :
02/07/2025
Initiation :
09/07/2016
Primary completion :
10/31/2019
Completion :
03/01/2025
BRAF
|
BRAF mutation • BRAF V600
|
Zelboraf (vemurafenib) • Cotellic (cobimetinib) • XL888
Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants with Advanced or Refractory Tumors (BGB-3245-AU-001) (NCT04249843)
Phase 1
MapKure, LLC
MapKure, LLC
Active, not recruiting
Phase 1
MapKure, LLC
Active, not recruiting
Last update posted :
02/07/2025
Initiation :
02/17/2020
Primary completion :
11/01/2025
Completion :
11/01/2025
KRAS • BRAF • NRAS
|
KRAS mutation • BRAF mutation • BRAF V600 • BRAF fusion
|
brimarefenib (BGB-3245)
Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma (NCT05628883)
Phase 1
H. Lee Moffitt Cancer Center and Research Institute
H. Lee Moffitt Cancer Center and Resear...
Recruiting
Phase 1
H. Lee Moffitt Cancer Center and Research Insti...
Recruiting
Last update posted :
02/07/2025
Initiation :
11/22/2022
Primary completion :
12/01/2025
Completion :
12/31/2026
BRAF • IL2
|
BRAF mutation • BRAF V600
|
cyclophosphamide • fludarabine IV • TIDAL-01
Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors (KEYNOTE B81) (NCT04609566)
Phase 2
Seagen Inc.
Seagen Inc.
Active, not recruiting
Phase 2
Seagen Inc.
Active, not recruiting
Last update posted :
02/07/2025
Initiation :
01/26/2021
Primary completion :
12/31/2025
Completion :
09/30/2026
EGFR • BRAF • ALK • ROS1
|
EGFR mutation • BRAF mutation • ALK mutation
|
Keytruda (pembrolizumab) • Adcetris (brentuximab vedotin)
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer (EA5163) (NCT03793179)
Phase 3
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 3
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
04/05/2019
Primary completion :
09/30/2027
Completion :
09/30/2027
EGFR • PD-L1 • BRAF • ALK • ROS1
|
PD-L1 expression • EGFR mutation • BRAF mutation • BRAF V600 • ALK translocation
|
Keytruda (pembrolizumab) • carboplatin • pemetrexed • Pembroria (pembrolizumab biosimilar) • Pemfexy (pemetrexed)
Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer (NCT01708954)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Active, not recruiting
Phase 2
National Cancer Institute (NCI)
Active, not recruiting
Last update posted :
02/06/2025
Initiation :
02/13/2013
Primary completion :
08/14/2015
Completion :
03/07/2025
HER-2 • KRAS • BRAF • RET
|
KRAS mutation • EGFR mutation • BRAF mutation • EGFR L858R • EGFR exon 19 deletion • RET mutation • RET rearrangement • EGFR L858R + EGFR exon 19 deletion
|
erlotinib • Cabometyx (cabozantinib tablet) • Cometriq (cabozantinib capsule)
Treatment Strategies in Colorectal Cancer Patients with Initially Unresectable Liver-only Metastases (CAIRO5) (NCT02162563)
Phase 3
Dutch Colorectal Cancer Group
Dutch Colorectal Cancer Group
Completed
Phase 3
Dutch Colorectal Cancer Group
Completed
Last update posted :
02/06/2025
Initiation :
07/01/2014
Primary completion :
07/01/2022
Completion :
01/01/2025
BRAF • RAS
|
BRAF mutation • RAS mutation
|
Avastin (bevacizumab) • 5-fluorouracil • Vectibix (panitumumab) • oxaliplatin • irinotecan • leucovorin calcium
A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (C4901001) (NCT05538130)
Phase 1
Pfizer
Pfizer
Recruiting
Phase 1
Pfizer
Recruiting
Last update posted :
02/06/2025
Initiation :
11/30/2022
Primary completion :
12/31/2027
Completion :
07/03/2029
BRAF
|
BRAF mutation • BRAF V600
|
Braftovi (encorafenib) • tinlorafenib (PF-07284890) • PF-07799544 • claturafenib (PF-07799933)
JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors (KEYNOTE-F62) (NCT06108050)
Phase 1
Jazz Pharmaceuticals
Jazz Pharmaceuticals
Recruiting
Phase 1
Jazz Pharmaceuticals
Recruiting
Last update posted :
02/05/2025
Initiation :
11/07/2023
Primary completion :
11/30/2027
Completion :
05/31/2028
BRAF • MSI
|
MSI-H/dMMR • BRAF mutation
|
Keytruda (pembrolizumab) • JZP898
Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial) (NCT03213691)
Phase 2
National Cancer Institute (NCI)
National Cancer Institute (NCI)
Completed
Phase 2
National Cancer Institute (NCI)
Completed
Last update posted :
02/05/2025
Initiation :
10/30/2017
Primary completion :
06/30/2021
Completion :
12/31/2024
BRAF
|
BRAF mutation • BRAF V600
|
Koselugo (selumetinib)
NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasis (NCT04129515)
Phase 1/2
Brown University
Brown University
Not yet recruiting
Phase 1/2
Brown University
Not yet recruiting
Last update posted :
02/04/2025
Initiation :
03/30/2025
Primary completion :
03/01/2026
Completion :
01/01/2027
BRAF
|
BRAF mutation • BRAF wild-type
|
Keytruda (pembrolizumab)
Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations (BEAVER) (NCT03839342)
Phase 2
University Health Network, Toronto
University Health Network, Toronto
Active, not recruiting
Phase 2
University Health Network, Toronto
Active, not recruiting
Last update posted :
02/03/2025
Initiation :
06/07/2019
Primary completion :
12/01/2025
Completion :
12/01/2025
BRAF • KIAA1549
|
BRAF mutation • BRAF V600K • BRAF fusion
|
Mektovi (binimetinib) • Braftovi (encorafenib)
Study of AIC100 CAR T Cells in Relapsed/Refractory Thyroid Cancer (NCT04420754)
Phase 1
AffyImmune Therapeutics, Inc.
AffyImmune Therapeutics, Inc.
Recruiting
Phase 1
AffyImmune Therapeutics, Inc.
Recruiting
Last update posted :
01/31/2025
Initiation :
09/28/2020
Primary completion :
08/04/2026
Completion :
08/04/2030
BRAF • ICAM1
|
BRAF mutation • BRAF wild-type
|
AIC100
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