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BIOMARKER:
BRAF K601E
i
Other names:
BRAF, B-raf proto-oncogene, B-raf proto-oncogene, Serine/threonine kinase, V-Raf murine sarcoma viral oncogene homolog B, Serine/threonine-protein kinase B-Raf, Proto-oncogene B-Raf, BRAF1, RAFB1, B-raf proto-oncogene Serine/threonine-protein kinase, Murine sarcoma viral (V-Raf) oncogene homolog B1, B-raf serine/threonine-protein, 94 KDa B-raf protein, B-RAF1
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Entrez ID:
673
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
‹
›
Associations
(7)
News
Trials
Phase
Status
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Phase
Status
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A Study of Binimetinib and Encorafenib in Advanced BRAF Mutant Cancers (NCT03843775)
Phase 1/2
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Completed
Phase 1/2
Memorial Sloan Kettering Cancer Center
Completed
Last update posted :
09/06/2023
Initiation :
02/14/2019
Primary completion :
09/02/2023
Completion :
09/02/2023
BRAF
|
BRAF mutation • BRAF fusion • BRAF K601E • BRAF G469A • BRAF L597Q • BRAF L485W • BRAF T599 • BRAF V600_K601delinsE • BRAF K601 • BRAF L597
|
Mektovi (binimetinib) • Braftovi (encorafenib)
Efficacy of MEK (Trametinib) and BRAFV600E (Dabrafenib) Inhibitors With Radioactive Iodine (RAI) for the Treatment of Refractory Metastatic Differentiated Thyroid Cancer (MERAIODE) (NCT03244956)
Phase 2
Gustave Roussy, Cancer Campus, Grand Paris
Gustave Roussy, Cancer Campus, Grand Paris
Active, not recruiting
Phase 2
Gustave Roussy, Cancer Campus, Grand Paris
Active, not recruiting
Last update posted :
09/28/2021
Initiation :
12/27/2017
Primary completion :
11/18/2021
Completion :
12/01/2022
KRAS • NRAS • HRAS
|
BRAF V600E • BRAF V600 • HRAS mutation • BRAF K601E • BRAF K601
|
Mekinist (trametinib) • Tafinlar (dabrafenib)
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