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    BIOMARKER:

    BCR-ABL1 fusion

    i
    Entrez ID:
    25; 613
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    Related tests:
    Apply
    Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (AALL1631) (NCT03007147)
    Phase 3
    Children's Oncology Group
    Active, not recruiting
    Last update posted :
    02/13/2025
    Initiation :
    08/08/2017
    Primary completion :
    09/30/2027
    Completion :
    09/30/2027
    ABL1 • BCR • PDGFRA • PDGFRB • IKZF1 • CSF1R
    |
    BCR-ABL1 fusion • ABL1 fusion
    |
    imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • ifosfamide • etoposide IV • methotrexate • vincristine • daunorubicin • dexamethasone • leucovorin calcium • Oncaspar liquid (pegaspargase) • mercaptopurine delayed release (DR6MP) • mercaptopurine • Asparlas (calaspargase pegol-mknl) • thioguanine • Hemady (dexamethasone tablets) • Neupogen (filgrastim) • Starasid (cytarabine ocfosfate) • cyclophosphamide intravenous • dexrazoxane • levoleucovorin calcium • prednisolone
    Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (NCT04329325)
    Phase 2
    Memorial Sloan Kettering Cancer Center
    Active, not recruiting
    Last update posted :
    05/24/2024
    Initiation :
    03/30/2020
    Primary completion :
    03/01/2025
    Completion :
    03/01/2025
    ABL1 • BCR
    |
    BCR-ABL1 fusion
    |
    dasatinib • Blincyto (blinatumomab) • dexamethasone • hydroxyurea
    A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (NCT04501614)
    Phase 1/2
    Takeda
    Active, not recruiting
    Last update posted :
    03/04/2024
    Initiation :
    02/24/2021
    Primary completion :
    12/19/2024
    Completion :
    01/04/2027
    ABL1 • BCR • IGH • PDGFRB • CSF1R • PIAS4
    |
    BCR-ABL1 fusion • BCR-ABL1 T315I • ABL1 T315I • BCR-ABL1 mutation
    |
    cytarabine • Iclusig (ponatinib) • cyclophosphamide
    Ponatinib in Participants With Resistant Chronic Phase Chronic Myeloid Leukemia (CP-CML) to Characterize the Efficacy and Safety of a Range of Doses (OPTIC) (NCT02467270)
    Phase 2
    Takeda
    Active, not recruiting
    Last update posted :
    02/06/2024
    Initiation :
    06/30/2015
    Primary completion :
    04/14/2020
    Completion :
    06/01/2024
    ABL1 • BCR
    |
    BCR-ABL1 fusion • ABL1 T315I • BCR-ABL1 mutation
    |
    Iclusig (ponatinib)
    Is There an Association Between Innate CD8+ T Cells and the Evolution of Tyrosine Kinase Inhibitor Resistance Mutations in Phi+ Hematological Malignancies. (TIPHI) (NCT04965649)
    Phase N/A
    Centre Hospitalier Universitaire de Nīmes
    Recruiting
    Last update posted :
    08/30/2023
    Initiation :
    01/01/2021
    Primary completion :
    07/01/2024
    Completion :
    01/01/2025
    ABL1 • CD8
    |
    BCR-ABL1 fusion
    A Study of HS-10382 in Patients With Chronic Myeloid Leukemia. (NCT05367700)
    Phase 1
    Jiangsu Hansoh Pharmaceutical Co., Ltd.
    Recruiting
    Last update posted :
    01/13/2023
    Initiation :
    04/28/2022
    Primary completion :
    12/30/2024
    Completion :
    09/30/2026
    ABL1 • BCR
    |
    BCR-ABL1 fusion
    |
    TERN-701
    Glasdegib-Based Treatment Combinations for the Treatment of Patients With Relapsed Acute Myeloid Leukemia Who Have Undergone Hematopoietic Cell Transplantation (NCT04655391)
    Phase 1b
    City of Hope Medical Center
    Withdrawn
    Last update posted :
    06/09/2022
    Initiation :
    06/25/2022
    Primary completion :
    12/15/2023
    Completion :
    12/15/2023
    FLT3 • ABL1 • BCR • IDH1 • AXL
    |
    IDH1 mutation • BCR-ABL1 fusion • FLT3 mutation • FLT3 D835 • IDH1 R132 • FLT3 I836
    |
    Venclexta (venetoclax) • Xospata (gilteritinib) • azacitidine • Bosulif (bosutinib) • decitabine • Tibsovo (ivosidenib) • Idhifa (enasidenib) • Daurismo (glasdegib)
    Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia (NCT00707083)
    Phase 3
    Prince of Wales Hospital, Shatin, Hong Kong
    Completed
    Last update posted :
    03/05/2020
    Initiation :
    05/01/2008
    Primary completion :
    10/01/2018
    Completion :
    03/01/2020
    ABL1
    |
    BCR-ABL1 fusion • MLL rearrangement
    |
    methotrexate • vincristine • dexamethasone • mercaptopurine • dexamethasone injection
    Efficacy and Safety of Nilotinib in CML-CP (ENESTKorea) (NCT03332511)
    Phase 4
    Seoul National University Hospital
    Completed
    Last update posted :
    11/06/2017
    Initiation :
    05/06/2013
    Primary completion :
    10/24/2016
    Completion :
    10/24/2016
    ABL1 • BCR
    |
    BCR-ABL1 fusion
    |
    Tasigna (nilotinib)