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    BIOMARKER:

    AKT1 overexpression

    i
    Other names: AKT1, AKT, PKB, PRKBA, RAC, V-akt murine thymoma viral oncogene homolog 1
    Entrez ID:
    207
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    Apply
    Safety and Efficacy of BKM120 and Lapatinib in HER2+/PI3K-activated, Trastuzumab-resistant Advanced Breast Cancer (PIKHER2) (NCT01589861)
    Phase 1/2
    Institut Paoli-Calmettes
    Suspended
    Last update posted :
    03/28/2017
    Initiation :
    12/01/2011
    Primary completion :
    01/01/2018
    Completion :
    01/01/2018
    HER-2 • PIK3CA • PTEN
    |
    HER-2 positive • PIK3CA mutation • PTEN mutation • AKT1 overexpression • PIK3CA expression • PIK3CA overexpression • PTEN negative
    |
    Herceptin (trastuzumab) • lapatinib • buparlisib (AN2025)