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    DRUG CLASS:

    ACVR1 inhibitor

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    Phase II Study of Pacritinib in Kaposi Sarcoma Herpesvirus (KSHV)-Associated Multicentric Castleman Disease and KSHV-Associated Inflammatory Cytokine Syndrome (KICS) (NCT06052618)
    Phase 2
    National Cancer Institute (NCI)
    Recruiting
    Last update posted :
    02/24/2025
    Initiation :
    02/27/2025
    Primary completion :
    01/01/2033
    Completion :
    01/01/2034
    CRP
    |
    Vonjo (pacritinib)
    A Phase I/II GVHD Prevention Trial Combining Pacritinib With Sirolimus-Based Immune Suppression (NCT02891603)
    Phase 1/2
    H. Lee Moffitt Cancer Center and Research Insti...
    Completed
    Last update posted :
    03/25/2024
    Initiation :
    06/08/2017
    Primary completion :
    01/28/2022
    Completion :
    04/18/2022
    IL6 • HLA-DRB1 • CD4 • HLA-B • HLA-C
    |
    sirolimus • Vonjo (pacritinib)
    Momelotinib in Transfusion-Dependent Adults With Primary Myelofibrosis (PMF) or Post-polycythemia Vera or Post-essential Thrombocythemia Myelofibrosis (Post-PV/ET MF) (NCT02515630)
    Phase 2
    Sierra Oncology LLC - a GSK company
    Completed
    Last update posted :
    06/19/2023
    Initiation :
    01/29/2016
    Primary completion :
    07/18/2017
    Completion :
    08/15/2017
    CRP
    |
    Ojjaara (momelotinib)
    A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of E6201 in Subjects With Advanced Solid Tumors (NCT00794781)
    Phase 1
    Eisai Inc.
    Completed
    Last update posted :
    10/14/2022
    Initiation :
    06/22/2008
    Primary completion :
    08/01/2011
    Completion :
    10/15/2015
    BRAF
    |
    E6201
    A Single Arm, Phase Ib/II Trial of Single Agent Pacritinib in Patients With 1q21.3 Amplified Solid Tumors Enriching for Interleukin-1 Receptor-associated Kinase 1 Pathway Activation (PAIR) (NCT04520269)
    Phase 1/2
    National University Hospital, Singapore
    Recruiting
    Last update posted :
    08/20/2020
    Initiation :
    07/13/2020
    Primary completion :
    07/01/2023
    Completion :
    07/01/2023
    S100A8
    |
    Vonjo (pacritinib)
    Pacritinib and Chemotherapy in Treating Patients With Acute Myeloid Leukemia and FLT3 Mutations (NCT02323607)
    Phase 1
    Bhavana Bhatnagar
    Completed
    Last update posted :
    01/25/2019
    Initiation :
    01/12/2016
    Primary completion :
    07/12/2018
    Completion :
    07/12/2018
    FLT3
    |
    FLT3 mutation
    |
    cytarabine • decitabine • daunorubicin • Vonjo (pacritinib)