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CANCER:

Estrogen Receptor Positive Breast Cancer





Show legend
Group by Gene:
Include preclinical:

tamoxifen
0
Estrogen receptor antagonist
tamoxifen
tamoxifen
fulvestrant
elacestrant
SAR439859
1
Selective estrogen receptor degrader
SCR-6852
LY3484356
AZD9833
SCR6106
palbociclib
ribociclib
2
CDK4 inhibitor, CDK6 inhibitor
abemaciclib
PRT3645
CDK4 inhibitor + CDK6 inhibitor
letrozole
3
Aromatase inhibitor
exemestane
anastrozole
Aromatase inhibitor
4
AKT inhibitor
capivasertib
5
VEGF-A inhibitor
bevacizumab
6
Bcl2 inhibitor
venetoclax
7
Multi-tyrosine kinase inhibitor
ponatinib
vandetanib
8
HER2 inhibitor, HER3 inhibitor
MCLA-128
9
PARP inhibitor
olaparib
10
eIF4A1 inhibitor, CDK4 inhibitor, CDK6 inhibitor
abemaciclib + eFT226
palbociclib + CR-1-31-B
11
Selective estrogen receptor modulator
toremifene
lasofoxifene
12
Aurora kinase A inhibitor
MLN8237
13
Notch inhibitor
RG4733
14
HDAC inhibitor, HDAC1 inhibitor, HDAC2 inhibitor, HDAC3 inhibitor
entinostat
15
Proteasome inhibitor
ixazomib
16
Estrogen receptor antagonist, mTORC1 inhibitor, mTORC2 inhibitor
tamoxifen + CB-228
17
PIK3CA inhibitor
alpelisib
18
HER2 inhibitor, HER2 dimerization inhibitor
trastuzumab + pertuzumab
19
FGFR inhibitor
ABSK091
20
Microtubule inhibitor, Notch3-targeted antibody-drug conjugate
PF-06650808
21
HER2 inhibitor
tucatinib
22
Immunotherapy, Selective estrogen receptor degrader
Immunotherapy + fulvestrant
23
Androgen receptor modulator, Selective androgen receptor modulator
enobosarm
24
Selective estrogen receptor modulator, Estrogen receptor antagonist
Z-endoxifen hydrochloride
25
Aromatase inhibitor, HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
pyrotinib + letrozole
26
Estrogen receptor antagonist, GnRH agonist
tamoxifen + goserelin acetate
27
HER2 inhibitor, HER4 inhibitor, EGFR inhibitor
trastuzumab + neratinib
neratinib
28
MDMX inhibitor, MDM2 inhibitor
ALRN-6924
29
JAK1 inhibitor, JAK2 inhibitor
ruxolitinib
30
PIK3CA inhibitor, Estrogen receptor antagonist
tamoxifen + GDC-0032
31
VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
sunitinib
32
CDK4 inhibitor, PI3K inhibitor, mTOR inhibitor, mTORC1 inhibitor, CDK6 inhibitor, mTORC2 inhibitor
palbociclib + PF-05212384
33
DNA synthesis inhibitor, DNA cross linking agent, Apoptosis inhibitor, Microtubule inhibitor
INT230-6
34
AMPK activator
metformin
35
Estrogen receptor antagonist, Selective estrogen receptor degrader
GDC-9545
OP-1250
36
BET inhibitor
ZEN-3694
37
MCL1 inhibitor, Bcl-xL inhibitor
S63845 + A-1331852
38
PI3K inhibitor, Bcl-xL inhibitor, AKT inhibitor
RG7440 + A-1331852
39
Topoisomerase II inhibitor, Selective estrogen receptor modulator, Selective estrogen receptor α inhibitor, PKCβ inhibitor
doxorubicin hydrochloride + Z-endoxifen
40
HER3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
U3-1402
41
CDK4 inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
palbociclib + SAR439859
42
HER2-targeted antibody-drug conjugate, Topoisomerase I inhibitor
fam-trastuzumab deruxtecan-nxki
43
CDK19 inhibitor, CDK4 inhibitor, CDK6 inhibitor, CDK8 inhibitor
palbociclib + Senexin B
palbociclib + SNX-631
44
CDK4 inhibitor, CDK6 inhibitor, Serine protease inhibitor, TMPRSS2 inhibitor
palbociclib + nafamostat
45
Serine protease inhibitor, TMPRSS2 inhibitor
nafamostat
46
CDK4 inhibitor, Sonic hedgehog inhibitor, Stem cell inhibitor, Apoptosis stimulant, CDK6 inhibitor
palbociclib + GZ17-6.02
47
ERK2 inhibitor, ERK1 inhibitor
BVD-523
48
HER2 inhibitor, EGFR inhibitor
lapatinib
49
Immunostimulant, Free radical stimulant, Oxidative stress enhancer
SM-88
50
Selective estrogen receptor degrader, WEE1 inhibitor
ZN-c3 + ZN-c5
51
CDK4 inhibitor, CDK6 inhibitor, WEE1 inhibitor
palbociclib + ZN-c3
52
WEE1 inhibitor
ZN-c3
53
Estrogen receptor antagonist, CDK4 inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
palbociclib + OP-1250
54
PKC inhibitor
AEB071
MK-8776
LY 2603618
55
Chk1 inhibitor
CHIR-124
PD-407824
PF-00477736
56
Chk1 inhibitor, Chk2 inhibitor
ACR-368
AZD-7762
57
ATR inhibitor
M6620
58
LATS kinase inhibitor
VT02956
59
MYC inhibitor
MYCi975
60
Tubulin polymerization promoter
carboplatin
61
IAP inhibitor
IGM-9427
62
USP8 inhibitor
DC-U4106
63
PRMT5 inhibitor
GSK3326595
64
ATR inhibitor, HER3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
U3-1402 + BAY 1895344
65
PI3K inhibitor
SB02024
AN2025
66
Microtubule inhibitor, LIV-1-targeted antibody-drug conjugate
BRY812
67
Selective estrogen receptor activator, Cell death stimulant, Unfolded protein response activator
TEQ103
68
Androgen receptor antagonist
apalutamide
69
Selective androgen receptor modulator
EP0062
70
CDK2 inhibitor, CDK4 inhibitor, CDK6 inhibitor
RGT-419B
71
CDK4 inhibitor, CDK6 inhibitor, PDK1 inhibitor
palbociclib + VRx-510
ribociclib + VRx-510
72
CDK7 inhibitor
YPN-005
73
NEDD8 activating enzyme inhibitor
MLN4924
74
CDK4 inhibitor, CDK6 inhibitor, MDM2 inhibitor
palbociclib + CGM097
75
MDM2 inhibitor
CGM097
76
DRD1 partial agonist
levo-tetrahydropalmatine
77
TrxR inhibitor, AKT inhibitor
MK-2206 + D9
78
SF3B1 inhibitor, RNA splicing modulator
SSA
79
ER-α 36 modulator
SNG-162
80
Androgen receptor inhibitor
darolutamide
enzalutamide capsule
81
BET inhibitor, CDK4 inhibitor, CDK6 inhibitor
palbociclib + ZEN-3694
abemaciclib + ZEN-3694
82
CDK4 inhibitor, CDK6 inhibitor, Bcl2 inhibitor
palbociclib + APG-2575
83
β-catenin inhibitor, Tubulin polymerization promoter, CBP inhibitor, Microtubule inhibitor, Bcl2 inhibitor
paclitaxel + eribulin mesylate
84
PIK3CA inhibitor, CDK4 inhibitor, mTOR inhibitor, CDK6 inhibitor, Selective estrogen receptor degrader
everolimus + alpelisib + abemaciclib + LY3484356
85
pan-RAF inhibitor, Multi-tyrosine kinase inhibitor
sorafenib
86
XPO1 inhibitor, Nuclear export inhibitor
KPT-8602
87
PI3Kα H1047R mutation inhibitor, CDK4 inhibitor, CDK6 inhibitor
palbociclib + STX-478
88
CDK4 inhibitor, CDK6 inhibitor, CDK9 inhibitor
palbociclib + AZD4573
89
Aurora kinase inhibitor, WEE1 inhibitor
WEE1 inhibitor + Aurora kinase inhibitor
90
Immunotherapy
Immunotherapy
ER positive
ESR1 rs9322354
ER mutation
ESR1 rs2228480
ER Y537S
ESR1 rs1801132
ESR1 mutation
ER D538G
ER-L
ER overexpression
HER-2 mutation
IGFBP7 overexpression
HSD17B2 overexpression
HER-2 overexpression
HER-2 positive
TP53 wild-type
BCL2 positive
PTEN mutation
AR positive
EPRS1 expression
FTO expression
CTDSP1 expression
BIN3 expression
NOS2 underexpression
RET overexpression
FOXD1 expression
WSB2 expression
PIK3CA mutation
CCNB2 expression
AKT1 E17K
KDR V297I
SLBP expression
RBPMS expression
ASXL1 mutation
BRCA2 overexpression
CCNE1 mutation
LLGL2 underexpression + SLC7A5 underexpression
SLC7A5 underexpression
LLGL2 underexpression
EZH2 rs2302427C>G
PRMT5 overexpression
NOTCH3 expression
SLC3A2-NRG1 fusion
CCNE1 overexpression
CCNE1 expression
AR overexpression
EZH2 rs201135441C>T
76-gene signature
SEMA7A overexpression
SF3B1 K666Q
SF3B1 K700E
FGF3 mutation
FGFR2 mutation
ERBB3 expression
FGFR1 mutation
PLK1 overexpression
MYC amplification
PAK4 deletion
NPY1R underexpression
SPRED2 deletion
CDKN2A deletion
FGFR1 amplification
NOTCH4 expression
NOTCH1 expression + NOTCH4 expression
EGFR overexpression
NOTCH1 expression
APBB1 expression
LAMTOR5 overexpression
PPP3CA expression
SOX2 overexpression
AGR2 elevation
TRIM3 overexpression
SALL4 overexpression
NODAL overexpression
IL6R overexpression
RUNX3 underexpression
BRCA1 L1780P
RB1 deletion
SOX9 overexpression
CDKN2A overexpression
35-gene signature
MIR497HG deletion
NCOR2 overexpression
AGR2 overexpression
CCND1 overexpression
CCND1 amplification
CDK2 overexpression
HPGD underexpression
AURKA overexpression
RSF1 amplification
CDK6 overexpression
ARID1A deletion
RFC3 overexpression + ER positive
FOXA1 mutation
MAP3K1 mutation
SF3B1 K666E