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Show legend
Group by Gene:
Include preclinical:

0
TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor
larotrectinib
bevacizumab
bevacizumab-maly
bevacizumab-adcd
1
VEGF-A inhibitor
bevacizumab-tnjn
bevacizumab-bvzr
Krabeva (bevacizumab biosimilar)
bevacizumab-awwb
Byvasda (bevacizumab biosimilar)
temozolomide
cisplatin
2
DNA synthesis inhibitor
mitomycin
dacarbazine
gemcitabine
3
Alkylating agent
lomustine
cyclophosphamide
etoposide IV
4
Topoisomerase II inhibitor
RTA 744
teniposide
5
Tubulin polymerization promoter
carboplatin
6
MEK inhibitor, BRAF inhibitor
trametinib + dabrafenib
BRAF inhibitor + MEK inhibitor
regorafenib
anlotinib
7
Multi-tyrosine kinase inhibitor
cabozantinib tablet
pazopanib
ponatinib
8
Hedgehog cell-signalling pathway inhibitor
vismodegib
sonidegib
9
Alkylating agent, Tubulin polymerization inhibitor
lomustine + procarbazine hydrochloride + vincristine liposomal
vincristine + lomustine + procarbazine hydrochloride
10
mTOR inhibitor
everolimus
temsirolimus
ERC1671
AV-GBM-1
11
Immunostimulant
VBI-1901
UCPVax
Histone H3.3-K27M Neoantigen Vaccine Therapy
PD1 inhibitor
12
PD1 inhibitor
nivolumab
pembrolizumab
13
Topoisomerase II inhibitor, DNA inhibitor
etoposide oral
14
MEK1 inhibitor
cobimetinib
15
Apoptosis stimulant
teserpaturev
16
SSTR agonist
DG3173
17
VEGF-A inhibitor, mTOR inhibitor
bevacizumab + everolimus
18
Tubulin polymerization promoter, Tubulin polymerization inhibitor
carboplatin + vincristine
trametinib
19
MEK inhibitor
selumetinib
PD-0325901
EGFR inhibitor
ERAS-801
panitumumab
20
EGFR inhibitor
erlotinib
gefitinib
osimertinib
nimotuzumab
cetuximab
futibatinib
21
FGFR inhibitor
pemigatinib
ABSK091
infigratinib
22
pan-RAF inhibitor
DAY101
ABM-1310
23
BRAF inhibitor
dabrafenib
PLX4720
24
Alkylating agent, BRD4 inhibitor
VAL-083
25
BRAF inhibitor, BRAF V600E inhibitor
vemurafenib
FORE-8394
GLR2007
26
CDK4 inhibitor, CDK6 inhibitor
abemaciclib
palbociclib
27
Oxygen radical scavenger
OKN-007
28
Immunostimulant, Cell death stimulant
DNX-2401
29
NK cell stimulant
CYNK-001
30
Casein kinase 2 inhibitor
CX-4945
31
CEBPB antagonist
ST101
32
Survivin inhibitor
SVN53-67 / M57-KLH peptide vaccine
33
Cytotoxic T lymphocyte stimulant
DOC1021
CAN-3110
34
TERT inhibitor
RZ-001
35
XPO1 inhibitor
selinexor
ivosidenib
36
IDH1 inhibitor
BAY1436032
AGI-5198
37
CXCL12 inhibitor
NOX-A12
38
PRMT5 inhibitor
PRT811
TNG908
39
ALK inhibitor
crizotinib
40
ERK2 inhibitor, ERK1 inhibitor
BVD-523
41
mTOR inhibitor, BRAF inhibitor, BRAF V600E inhibitor
vemurafenib + everolimus
42
AMPK activator
metformin
carmustine
43
Alkylating agent, DNA synthesis inhibitor
temozolomide gel
temozolomide + carmustine
temozolomide + lomustine
44
PD-L1 inhibitor
PD-L1 inhibitor
atezolizumab
45
Reactive oxygen species stimulant, Photosensitizer
verteporfin
46
VEGF-A inhibitor, EGFR inhibitor
bevacizumab + osimertinib
bevacizumab + erlotinib
47
Microtubule inhibitor, EGFRvIII-targeted antibody-drug conjugate
AMG 595
48
TNFα inhibitor
onfekafusp alfa
49
HIF-2α inhibitor
belzutifan
bevacizumab + retifanlimab-dlwr
50
VEGF-A inhibitor, PD1 inhibitor
nivolumab + bevacizumab
pembrolizumab + bevacizumab
51
FAK inhibitor
GSK2256098
52
VEGF-A inhibitor, Multi-tyrosine kinase inhibitor
bevacizumab + anlotinib
53
EGFR inhibitor, EGFRvIII inhibitor
WSD0922
54
HDAC inhibitor
panobinostat
romidepsin
55
PD1 inhibitor, CTLA4 inhibitor
nivolumab + ipilimumab
56
Integrin inhibitor
cilengitide
57
DNA replication inhibitor, EGFR-targeted antibody-drug conjugate
ABBV-321
pamiparib
58
PARP inhibitor
niraparib
talazoparib
olaparib
59
VEGFR inhibitor
cediranib
60
DNA synthesis inhibitor, Multi-tyrosine kinase inhibitor
anlotinib + temozolomide
61
Microtubule inhibitor, EGFR-targeted antibody-drug conjugate
ABT-414
ABBV-221
62
VEGFR-2 inhibitor, DNA synthesis inhibitor
temozolomide + rivoceranib
63
TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
entrectinib
64
BRAF inhibitor, MEK1 inhibitor, BRAF V600E inhibitor
vemurafenib + cobimetinib
65
CAR-T immunotherapy
CAR-T immunotherapy
66
Immunotherapy
Immunotherapy
67
PD-L1 inhibitor, IDH1 inhibitor
PD-L1 inhibitor + IDH1 inhibitor
68
SMO protein inhibitor
SMO protein inhibitor
69
ENO1 inhibitor
ENO1 inhibitor
70
Hypomethylating agent
Hypomethylating agent
71
EGFRvIII-targeted CAR-T immunotherapy
EGFRvIII-targeted CAR-T immunotherapy
72
Chemotherapy
PCV
73
Topoisomerase I inhibitor
Topoisomerase I inhibitor
74
Activin receptor inhibitor
Activin receptor inhibitor
75
HER2 inhibitor, EGFR inhibitor
lapatinib
Bay846
76
Topoisomerase II inhibitor, DNA synthesis inhibitor
cisplatin + etoposide IV
77
VEGFR inhibitor, PDGFR inhibitor, c-KIT inhibitor
sunitinib
78
Topoisomerase II inhibitor, Tubulin polymerization promoter, Alkylating agent, DNA inhibitor
carboplatin + cyclophosphamide + etoposide oral
79
Topoisomerase II inhibitor, Alkylating agent, DNA inhibitor
cyclophosphamide + etoposide oral
80
Topoisomerase II inhibitor, Alkylating agent, DNA synthesis inhibitor
cisplatin + cyclophosphamide + etoposide IV
81
Alkylating agent, Tubulin polymerization inhibitor, DNA synthesis inhibitor
cisplatin + cyclophosphamide + vincristine
cisplatin + vincristine + lomustine
82
DNA synthesis inhibitor, Chemotherapy
PCV + thioguanine
83
FGFR2 inhibitor, FGFR inhibitor, FGFR1 inhibitor, FGFR3 inhibitor, FGFR4 inhibitor
erdafitinib
84
ERK inhibitor, AKT inhibitor
ONC201
85
PI3K inhibitor, PKCβ inhibitor, AKT inhibitor
enzastaurin
86
Microtubule destabilizing agent, Vascular disrupting agent, Apoptosis stimulant
BAL101553
87
Vascular disrupting agent, Angiogenesis inhibitor
VB-111
88
Glycolysis inhibitor, Viral replication inhibitor
WP1122
89
MEK2 inhibitor, MEK1 inhibitor
FCN-159
90
PI3K inhibitor, mTOR inhibitor, AKT inhibitor
GDC-0084
91
DNA synthesis inhibitor, IFNα 2b stimulant
temozolomide + interferon α-2b
92
Gene transference, Thymidine kinase stimulant, PD1 inhibitor
nivolumab + aglatimagene besadenovec
93
ERK5 inhibitor, CDK2 inhibitor, JAK2 inhibitor, CDK9 inhibitor, FLT3 inhibitor, CDK7 inhibitor, CDK1 inhibitor, CDK5 inhibitor
TG02
94
TSP1 stimulant, CD36 stimulant
VT1021
95
IDH2 inhibitor, IDH1 inhibitor
S95032
96
BRAF inhibitor, BRAF V600E inhibitor, Cytochrome P450 inhibitor
FORE-8394 + cobicistat
97
DNA synthesis inhibitor, EGFR inhibitor, Multi-tyrosine kinase inhibitor
anlotinib + temozolomide + aumolertinib
98
ROS1 inhibitor, ALK inhibitor
lorlatinib
99
cRAF inhibitor, MEK inhibitor, BRAF inhibitor
binimetinib + encorafenib
100
DNA synthesis inhibitor, PARP inhibitor
temozolomide + ABT-888
101
RAS inhibitor, Apoptosis stimulant
NEO100
102
VEGFR inhibitor, HER2 inhibitor, EGFR inhibitor, EphB4 inhibitor
KD019
103
JAK1 inhibitor, JAK2 inhibitor
ruxolitinib
104
TGFβ inhibitor, PD-L1 inhibitor
M7824
105
PD-L1 inhibitor, PI3K inhibitor, AKT inhibitor
atezolizumab + RG7440
106
Wilms tumor 1 inhibitor, Cytotoxic T lymphocyte stimulant, PD1 inhibitor, PSMA inhibitor, hTERT inhibitor, IL-12 stimulant
cemiplimab-rwlc + INO-5401 + INO-9012
107
VEGFR inhibitor, PDGFR inhibitor, DNA synthesis inhibitor, c-KIT inhibitor
sunitinib + temozolomide
108
CASP3 stimulant, DNA synthesis inhibitor
temozolomide + PAC-1
109
VEGF-A inhibitor, ERK inhibitor, AKT inhibitor
bevacizumab + ONC201
110
PD-L1 inhibitor, MEK1 inhibitor
atezolizumab + cobimetinib
111
EphA3 inhibitor, EPH receptor inhibitor
KB004
112
CD133-targeted CAR-T immunotherapy
CD133-specific CAR-T cell therapy
113
Nicotinamide phosphoribosyltransferase inhibitor
APO866
114
PKC inhibitor
RO-31-8220
115
HDAC inhibitor, PI3K inhibitor
CUDC-907
AN2025 + panobinostat
116
TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, CDK4 inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, CDK6 inhibitor, TNK2 inhibitor
entrectinib + abemaciclib
117
PI3K inhibitor
AN2025
118
PI3K inhibitor, mTOR inhibitor
AN2025 + sirolimus
119
EGFR MasterKey inhibitor, EGFR inhibitor
BDTX-1535
120
GPC-1-targeted antibody-drug conjugate
anti-GPC-1 ADC
121
NEDD8 activating enzyme inhibitor
MLN4924
122
RET inhibitor
FHND5071
123
α radiation emission, EGFRvIII inhibitor
Undisclosed EGFRvIII-targeted alpha therapy
124
PARP1 inhibitor, DNA synthesis inhibitor
temozolomide + AZD9574
125
CDK2 inhibitor, CDK9 inhibitor, CDK7 inhibitor
CYC065 + SY‑079
126
ATR inhibitor, PARP inhibitor
olaparib + AZD6738
127
DNMT inhibitor
decitabine
128
SMO protein inhibitor, Hedgehog cell-signalling pathway inhibitor
IPI 926 oral
129
Tubulin polymerization promoter, Bcl2 inhibitor
paclitaxel
130
Topoisomerase II inhibitor, DNA intercalator
daunorubicin
131
Tubulin polymerization inhibitor
vincristine
132
BMI1 inhibitor
PTC-209
133
PLK1 inhibitor
PCM-075
134
FGFR3-targeted antibody-drug conjugate, Topoisomerase I inhibitor
AMB302
135
Chk1 inhibitor, PARP inhibitor
olaparib + MK-8776
136
mTOR inhibitor, Multi-tyrosine kinase inhibitor
everolimus + vandetanib
137
Proteasome inhibitor
NPI-0052
138
MCL1 inhibitor, Protein synthesis inhibitor, MYC inhibitor, Apoptosis stimulant, G1-S-specific cyclin-D1 inhibitor
omacetaxine mepesuccinate
139
Topoisomerase II inhibitor, RNA synthesis inhibitor
dactinomycin
140
Tubulin polymerization promoter, Tubulin polymerization inhibitor, DNA synthesis inhibitor
carboplatin + temozolomide + vincristine
141
IL-7 agonist
efineptakin alfa
142
Telomerase inhibitor, VEGF-C inhibitor, NF-κB inhibitor
sodium metaarsenite
143
PD-L1 inhibitor, DNA synthesis inhibitor
atezolizumab + temozolomide
144
Androgen receptor inhibitor, AKT inhibitor
enzalutamide capsule + MK-2206
145
HER2 inhibitor, HER4 inhibitor, Androgen receptor inhibitor, EGFR inhibitor
afatinib + enzalutamide capsule
146
ATM kinase inhibitor
AZD1390
147
Glutamine antagonist
JHU395
148
VEGFR-2 inhibitor
rivoceranib
149
Bcl2 inhibitor, Bcl-xL inhibitor, Bcl-w inhibitor
ABT 263
150
DNA synthesis inhibitor, DNA methylation inhibitor
temozolomide + azacitidine
151
CYP51A1 inhibitor
itraconazole
152
IGF-1R inhibitor
ASP7487
153
TrkB receptor inhibitor, TrkC kinase inhibitor, ROS1 inhibitor, MEK inhibitor, TrkA receptor inhibitor, ALK inhibitor, JAK2 inhibitor, TNK2 inhibitor
trametinib + entrectinib
154
CDK4 inhibitor, BRAF inhibitor, CDK6 inhibitor
palbociclib + PLX4720
155
WEE1 inhibitor
AZD1775
156
MDM2-p53 antagonist
BI 907828
157
PTP-1B inhibitor
claramine
No biomarker
BRAF V600E
BRAF V600
BRAF mutation
BRAF wild-type
BRAF T599
BRAF fusion
BRAF V600E + BRAF L514V
IDH1 mutation + Chr del(1p) + Chr del(19q)
IDH1 mutation
IDH1 R132H
IDH1 overexpression
IDH2 mutation
IDH2 mutation + Chr del(1p) + Chr del(19q)
MGMT unmethylation
MGMT promoter methylation
MGMT underexpression
IDH1 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
IDH1 mutation + BRAF V600E
IDH1 wild-type + BRAF mutation
IDH2 mutation + NTRK2 fusion
IDH2 mutation + BRAF V600E
IDH2 mutation + NTRK3 fusion
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
IDH1 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK1 fusion
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK2 fusion
IDH2 mutation + Chr del(1p) + Chr del(19q) + NTRK3 fusion
IDH2 mutation + Chr del(1p) + Chr del(19q) + BRAF V600E
IDH1 mutation + NTRK1 fusion
IDH1 mutation + NTRK3 fusion
IDH1 mutation + NTRK2 fusion
IDH2 mutation + NTRK1 fusion
EGFR mutation
EGFR amplification
EGFRvIII mutation
EGFR overexpression
EGFR L858R
EGFR exon 2-7 deletion + EGFR amplification
EGFR expression
EGFRVIII overexpression
EGFR A289V
EGFRvIII expression
EGFR exon 20 insertion + EGFR T790M
NF1 mutation
NF1 deletion
NF1 2195G>T
NF1 470G>T
IDH wild-type
FGFR3-TACC3 fusion
TP53 mutation
MET amplification
FGFR1 fusion
TP53 wild-type
FGFR1 rearrangement
FGFR1 mutation
MET fusion
MET overexpression
NTRK3 fusion
PIK3CA mutation + TTN mutation + IDH2 mutation + Chr del(1q) + Chr del(17)
TMB-H
FGFR fusion
PD-L1 overexpression
PIK3CA mutation + TTN mutation + IDH2 mutation
FGFR mutation
TMB-L
NRAS wild-type
NRAS mutation
PD-L1 expression
PLEKHA4 underexpression
VHL mutation
NTRK2 fusion
NTRK1 fusion
MSI-H/dMMR
FGFR2 fusion
KIAA1549-BRAF fusion
PTEN mutation
PRSS3 underexpression
MMP2 elevation
miR-30b-3p underexpression
PTCH1 mutation
CD47 overexpression
TERT 124C>T
CD36 overexpression
CDH2 underexpression
TTN mutation + IDH2 mutation
CDKN2A-DT deletion
PIK3CA mutation + IDH2 mutation + Chr del(1q) + Chr del(17)
IDH2 mutation + MGMT promoter methylation
IDH1 mutation + MGMT promoter methylation
HLA-DQA1 overexpression
AGT underexpression
PDIA3 underexpression
P4HB underexpression
MMP9-L
VEGFA-L
EGFRVIII expression + PTEN expression
NID1 expression
EPHA3 positive
ABCB1 G412G
IDH1 mutation + WT1 overexpression
BCL7A overexpression
DOCK8 mutation
EP400 mutation
PDX1 mutation
SMO P641A
NF2 mutation
SP140 overexpression
IDH2 mutation + TMB-L
IDH1 mutation + TMB-L
HLA-A*02 + H3K27M
CDK4 amplification
CXCL12 expression
NEAT1 overexpression
FERMT3 overexpression
KRAS wild-type
PDGFRA amplification + KDR amplification
IDH1 wild-type + NF1 mutation
NACC2-NTRK2 fusion
IDH2 mutation + MYC amplification + MAPRE1 overexpression
IDH1 mutation + MYC amplification + MAPRE1 overexpression
TERT C228T + FGFR3 amplification + FGFR3-TACC3 fusion
ETV6-NTRK3 fusion
BRAF negative + GKAP1-NTRK2 exon 10-16 in-frame fusion
BRAF V600E + TERT mutation
BRAF V600E + PIK3CA mutation
TP53 mutation + TSC2 mutation
ALK fusion
FGFR1-TACC1 fusion
ZCCHC8-ROS1 fusion
IDH wild-type + FGFR3 S249C + TP53 V73fs
BRAF V600E + SOX2 amplification
GOPC-ROS1 fusion
SMO D477G
SMO D473H
VEGFA overexpression
CDK4 overexpression
VEGFA elevation
PTEN deletion
PTCH1 deletion
H3.3K27M
Chr del(1p)+ Chr del(19q)
Chr del(1p)
MYC expression
SUFU deletion
STAG2 mutation
REST signature
KLF4 K409Q
PTPN1 overexpression
CD133 positive
ASAP1 overexpression
KLC1-ROS1 fusion
GJA1 overexpression
ROS1 fusion
AIM2 deletion
TERT mutation + EGFR T790M + EGFR exon 20 insertion
NTRK-ROS1 fusion
PDGFRA amplification + NTRK2 fusion
CXCL8 overexpression
SAA1 underexpression
ACVR1 R206H
CD44 positive
ATRX mutation
BIRC5 mutation
ATRX deletion
CENPI overexpression
JARID2 overexpression
MYC amplification
MIF overexpression
MYCN amplification
ACVR1 mutation
IDH1 R132S + H3K27me3 loss + MET exon 14 skipping mutation
FABP7 overexpression
GSTP1 313A>G
GSTP1 overexpression
AEBP1 overexpression
KDR overexpression
MET overexpression + KDR overexpression
TNFA overexpression
BCL3 overexpression
TERT mutation + MGMT promoter methylation
RB1 expression
EPAS1 overexpression
SETD2 mutation + MGMT promoter methylation
CDKN2A deletion
BICD1 overexpression
PLK2 underexpression
PIGF overexpression
MSH2 deletion
IDH1 mutation + ATRX deletion + TP53 deletion
DKK3 overexpression
FLT1 overexpression
HSPA5 overexpression
FGFR3 overexpression
MTAP deletion
PIGF elevation
CCDC6-RET fusion
GPC1 overexpression
FLT1 elevation
PPM1B overexpression
FCER1G expression
GSTM1 expression + GSTM5 expression
BMI1 overexpression
NGFR expression
CD133 expression
PGP expression
NCAM1 expression
LIFR expression
CTSS overexpression
CD8 positive
VPS18 overexpression
RUNX1 overexpression
MDM2 amplification
ENO1 deletion
miR-370 underexpression
AKT1 overexpression
SUFU mutation
CCND1 overexpression
RB1 mutation