In the present group, the promoter of SOX17 gene was methylated in 61 out of 105 patients (58.1%)...Regarding response to treatment, complete response (CR) was seen in 0 out of 105 patients (0.0%), partial response (PR) was seen in 30 out of 105 patients (28.6%), stable disease (SD) was seen in 29 out of 105 patients (27.6%) and progressive disease (PD) in 46 out of 105 patients (43.8%).