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    Association details:
    Biomarker:NT5C2 R238W
    Cancer:Leukemia
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Blood
    Title:

    Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

    Excerpt:
    Similar results-increased resistance to 6-MP...and increased sensitivity to mizoribine- were documented in human ALL cell lines with expression of relapse associated NT5C2 mutations (p.R238W, p.K359Q, p.R367Q and p.D407A)....we verified increased response to mizoribine in relapsed-leukemia derived xenograft cells harboring NT5C2 mutations...
    DOI:
    10.1182/blood.V130.Suppl_1.2602.2602