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Association details:
| Biomarker: | MTAP deletion |
|---|---|
| Cancer: | Solid Tumor |
| Drug: | MRTX1719 (PRMT5 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
2779 / 2 - Identification of mechanism-based combination targets effective with the MTA-cooperative PRMT5 inhibitor MRTX1719 for the treatment of MTAP deleted cancers
Published date:
03/15/2023
Excerpt:
MRTX1719 inhibited the growth of an extensive panel of MTAP del cell line-derived and patient-derived xenograft tumor models across various indications.
